天津市某区域体检人群非酒精性脂肪肝调查分析(1)
摘要：目的 探索天津市某區域体检人群非酒精性脂肪肝的患病率现状及相关危险因素。方法 选取我院 2016年1月～2017年10月7528名参加体检人群为研究对象，统计NAFLD的检出率，分析各行为因素及实验室指标与NAFLD的相关性。结果 根据筛选标准，共有3256人纳入本研究，检出NAFLD计952例(29.24%);NAFLD与性别、作息习惯、饮食习惯、运动量、吸烟史、少量饮酒史及职业性质有关(P均<0.05);NAFLD患者更易伴有肥胖及高血压;NAFLD患者URIC[(287.10±42.15)μmol/L vs (226.89±39.61)μmol/L)]、FBG[(5.66±1.81)mmol/L vs (4.32±1.21)mmol/L]、LDL[(2.83±0.53)mmol/L vs (2.34±0.48)mmol/L]、VLDL[(0.45±0.12)mmol/L vs (0.33±0.08)mmol/L]、TC[(4.59±1.28)mmol/L vs (3.48±0.84)mmol/L)]、TG[(1.81±0.39)mmol/L vs (1.28±0.36)mmol/L)]高于非NAFLD体检者，且HDL[(1.32±0.27)mmol/L vs (1.64±0.32)mmol/L)]减低，差异均具有统计学意义(P均<0.05)。NALFD体检者更易检出水平异常增高的ALT及FBG(P均<0.05)。结论 天津市某区域体检人群NAFLD患病率约29.24%，男性、作息不规律、油腻饮食、低运动量、有吸烟史、少量饮酒史、内勤职业为NAFLD的高危因素，更易伴有尿酸、空腹血糖、低密度脂蛋白、极低密度脂蛋白、胆固醇、甘油三酯、谷丙转氨酶的升高及高密度脂蛋白的降低。具有上述高危因素的人群应尽早诊治。
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关键词：非酒精性脂肪性肝病;流行病学;高危因素;患病率;谷丙转氨酶
中图分类号：R188.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.04.032
文章编号：1006-1959(2019)04-0099-05
Abstract：Objective To investigate the prevalence of non-alcoholic fatty liver disease and related risk factors in a regional medical examination population in Tianjin. Methods A total of 7528 participants from January 2016 to October 2017 were enrolled in the study. The detection rate of NAFLD was statistically analyzed， and the correlation between various behavioral factors and laboratory indicators and NAFLD was analyzed. Results According to the screening criteria， a total of 3，256 people were included in the study， and 952 cases (29.24%) of NAFLD were detected. NAFLD was related to gender， work habits， eating habits， exercise volume， smoking history， small drinking history and occupational nature (P<0.05). Patients with NAFLD are more likely to be associated with obesity and hypertension;Patients with NAFLD had a URIC [(287.10±42.15) μmol/L vs (226.89±39.61) μmol/L)， FBG [(5.66±1.81) mmol/L vs (4.32±1.21) mmol/L]， LDL [(2.83±) 0.53) mmol/L vs (2.34±0.48) mmol/L]， VLDL [(0.45±0.12) mmol/L vs (0.33±0.08) mmol/L]， TC[(4.59±1.28) mmol/L vs (3.48 ±0.84)mmol/L)]， TG[(1.81±0.39) mmol/L vs (1.28±0.36 mmol/L)] was higher than non-NAFLD biopsy， and HDL [(1.32±0.27) mmol/L vs ( 1.64±0.32)mmol/L)] decreased， the difference was statistically significant (P<0.05). NALFD patients were more likely to detect abnormally elevated levels of ALT and FBG (P<0.05). Conclusion The prevalence of NAFLD in a certain physical examination population in Tianjin is about 29.24%. Men， irregular work schedule， greasy diet， low exercise volume， smoking history， a small amount of drinking history， and high-risk factors of NAFLD are more likely to be accompanied by uric acid and fasting blood glucose. ， low density lipoprotein， very low density lipoprotein， cholesterol， triglycerides， alanine aminotransferase and high density lipoprotein reduction. People with the above-mentioned high risk factors should be treated as soon as possible., 百拇医药(黄玲玉 孙东 蒋本君)
, http://www.100md.com
关键词：非酒精性脂肪性肝病;流行病学;高危因素;患病率;谷丙转氨酶
中图分类号：R188.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.04.032
文章编号：1006-1959(2019)04-0099-05
Abstract：Objective To investigate the prevalence of non-alcoholic fatty liver disease and related risk factors in a regional medical examination population in Tianjin. Methods A total of 7528 participants from January 2016 to October 2017 were enrolled in the study. The detection rate of NAFLD was statistically analyzed， and the correlation between various behavioral factors and laboratory indicators and NAFLD was analyzed. Results According to the screening criteria， a total of 3，256 people were included in the study， and 952 cases (29.24%) of NAFLD were detected. NAFLD was related to gender， work habits， eating habits， exercise volume， smoking history， small drinking history and occupational nature (P<0.05). Patients with NAFLD are more likely to be associated with obesity and hypertension;Patients with NAFLD had a URIC [(287.10±42.15) μmol/L vs (226.89±39.61) μmol/L)， FBG [(5.66±1.81) mmol/L vs (4.32±1.21) mmol/L]， LDL [(2.83±) 0.53) mmol/L vs (2.34±0.48) mmol/L]， VLDL [(0.45±0.12) mmol/L vs (0.33±0.08) mmol/L]， TC[(4.59±1.28) mmol/L vs (3.48 ±0.84)mmol/L)]， TG[(1.81±0.39) mmol/L vs (1.28±0.36 mmol/L)] was higher than non-NAFLD biopsy， and HDL [(1.32±0.27) mmol/L vs ( 1.64±0.32)mmol/L)] decreased， the difference was statistically significant (P<0.05). NALFD patients were more likely to detect abnormally elevated levels of ALT and FBG (P<0.05). Conclusion The prevalence of NAFLD in a certain physical examination population in Tianjin is about 29.24%. Men， irregular work schedule， greasy diet， low exercise volume， smoking history， a small amount of drinking history， and high-risk factors of NAFLD are more likely to be accompanied by uric acid and fasting blood glucose. ， low density lipoprotein， very low density lipoprotein， cholesterol， triglycerides， alanine aminotransferase and high density lipoprotein reduction. People with the above-mentioned high risk factors should be treated as soon as possible., 百拇医药(黄玲玉 孙东 蒋本君)