心力衰竭患者血清脑钠肽和白蛋白相关性分析(1)
摘要：目的 探讨心力衰竭(HF)患者的血清脑钠肽(BNP)与血清白蛋白(ALB)之间的关系以及低蛋白血症对入选患者近期预后的影响。方法 连续入选承德医学院附属医院本部心脏内科2017年6月～2018年8月收治的HF患者共150例，根据ALB浓度将入选者分为低蛋白血症组(61例)和对照组(89例)，在出院第30 d进行随访。结果 低蛋白血症组BNP值(1909.64±1640.90)pg/ml高于对照组(994.67±808.87) pg/ml(P<0.001)，低蛋白血症组谷丙转氨酶(121.21±57.12)U/L高于对照组(49.45±7.63)U/L (P=0.014)。ALB浓度与BNP对数转换值呈负相关(P<0.01)。低蛋白血症组和对照组患者30 d内HF死亡率分别为6.56%和1.12%(P=0.030)，30 d内HF再住院率分别为11.48%和3.37%(P=0.025)。结论 ALB浓度与BNP值呈负相关，合并低蛋白血症的HF患者近期预后不良。
关键词：心力衰竭;血清脑钠肽;血清白蛋白
, http://www.100md.com
中图分类号：R541.6 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.05.029
文章编号：1006-1959(2019)05-0098-03
Abstract：Objective To investigate the relationship between serum brain natriuretic peptide (BNP) and serum albumin (ALB) in patients with heart failure (HF) and the effect of hypoproteinemia on the short-term prognosis of enrolled patients. Methods A total of 150 patients with HF admitted to the Department of Cardiology， Affiliated Hospital of Chengde Medical College from June 2017 to August 2018 were enrolled. The patients were divided into hypoproteinemia group (61 cases)and The control group (89 cases) was followed up on the 30 d after discharge. Results The BNP value of the hypoproteinemia group (1909.64±1640.90) pg/ml was higher than that of the control group (994.67±808.87) pg/ml (P<0.001)， and the hypoproteinemia group alanine aminotransferase (121.21±57.12) U/L. It was higher than the control group (49.45±7.63) U/L (P=0.014). The ALB concentration was negatively correlated with the BNP logarithmic conversion value (P<0.01). The HF mortality rate was 6.56% and 1.12% (P=0.030) in the hypoproteinemia group and the control group， respectively， and the HF rehospitalization rate was 11.48% and 3.37% (P=0.025) within 30 d. Conclusion The ALB concentration is negatively correlated with the BNP value. The HF patients with hypoproteinemia have a poor prognosis in the near future.
, 百拇医药
Key words：Heart failure;Serum brain natriuretic peptide;Serum albumin
心力衰竭(heart failure，HF)是一种全球性的流行病[1]，是一系列心脏疾病沿时间发展而成的最后阶段，随着我国人口老龄化加速，HF的发病率持续增加，对人类生命安全构成了严重的威胁。流行病学研究显示该病发病率已达0.9%[2]，猝死发病率为13%[3]，成为导致现代社会人群死亡的重要原因之一[4]，且失代偿性HF患者接受住院治疗后1年死亡率仍可高达30%[5，6]。因此加强相关研究，尽早对HF患者进行诊断，及时进行适当治疗，提高生存率是当前极为重要的任务。多项研究都表明BNP对于HF的诊断、严重程度判斷和预后评估均具有重要的临床意义，尤其在HF的早期确诊、性质程度判断，以及指导临床治疗等方面均表现出明显的优越性[7-9]。临床研究显示，ALB是预测HF预后不良的指标之一[10-12]。虽然BNP和ALB均与HF有明显的相关性，但国内外关于HF患者BNP与ALB相关性的相关研究较少，本研究旨在探讨HF患者BNP与ALB的相关性及ALB与HF患者30 d内HF死亡率和再住院率之间的关系。为临床医生对HF患者的病情评估、评价预后提供参考。, http://www.100md.com(聂今心 丁振江 段华莹)
关键词：心力衰竭;血清脑钠肽;血清白蛋白
, http://www.100md.com
中图分类号：R541.6 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.05.029
文章编号：1006-1959(2019)05-0098-03
Abstract：Objective To investigate the relationship between serum brain natriuretic peptide (BNP) and serum albumin (ALB) in patients with heart failure (HF) and the effect of hypoproteinemia on the short-term prognosis of enrolled patients. Methods A total of 150 patients with HF admitted to the Department of Cardiology， Affiliated Hospital of Chengde Medical College from June 2017 to August 2018 were enrolled. The patients were divided into hypoproteinemia group (61 cases)and The control group (89 cases) was followed up on the 30 d after discharge. Results The BNP value of the hypoproteinemia group (1909.64±1640.90) pg/ml was higher than that of the control group (994.67±808.87) pg/ml (P<0.001)， and the hypoproteinemia group alanine aminotransferase (121.21±57.12) U/L. It was higher than the control group (49.45±7.63) U/L (P=0.014). The ALB concentration was negatively correlated with the BNP logarithmic conversion value (P<0.01). The HF mortality rate was 6.56% and 1.12% (P=0.030) in the hypoproteinemia group and the control group， respectively， and the HF rehospitalization rate was 11.48% and 3.37% (P=0.025) within 30 d. Conclusion The ALB concentration is negatively correlated with the BNP value. The HF patients with hypoproteinemia have a poor prognosis in the near future.
, 百拇医药
Key words：Heart failure;Serum brain natriuretic peptide;Serum albumin
心力衰竭(heart failure，HF)是一种全球性的流行病[1]，是一系列心脏疾病沿时间发展而成的最后阶段，随着我国人口老龄化加速，HF的发病率持续增加，对人类生命安全构成了严重的威胁。流行病学研究显示该病发病率已达0.9%[2]，猝死发病率为13%[3]，成为导致现代社会人群死亡的重要原因之一[4]，且失代偿性HF患者接受住院治疗后1年死亡率仍可高达30%[5，6]。因此加强相关研究，尽早对HF患者进行诊断，及时进行适当治疗，提高生存率是当前极为重要的任务。多项研究都表明BNP对于HF的诊断、严重程度判斷和预后评估均具有重要的临床意义，尤其在HF的早期确诊、性质程度判断，以及指导临床治疗等方面均表现出明显的优越性[7-9]。临床研究显示，ALB是预测HF预后不良的指标之一[10-12]。虽然BNP和ALB均与HF有明显的相关性，但国内外关于HF患者BNP与ALB相关性的相关研究较少，本研究旨在探讨HF患者BNP与ALB的相关性及ALB与HF患者30 d内HF死亡率和再住院率之间的关系。为临床医生对HF患者的病情评估、评价预后提供参考。, http://www.100md.com(聂今心 丁振江 段华莹)