卵巢癌合并2型糖尿病发生的危险因素分析(1)
摘要：目的 研究卵巢癌合并2型糖尿病的危险因素。方法 选择2010年1月～2017年12月我院住院病历中出院诊断为卵巢癌合并2型糖尿病，经病理确诊的21例患者设病例组，另选择未合并糖尿病的卵巢癌患者47例设为对照组，收集患者临床资料，包括一般情况、生育史、月经史、避孕史、家族史和既往史等，并采用非条件Logistic回归分析。结果 单因素分析显示，高血压、盆腔囊肿和高脂血症等是卵巢癌合并2型糖尿病的危险因素。多因素分析显示与卵巢癌合并2型糖尿病发生显著关联的是盆腔囊肿和高脂血症，OR值分别为8.536(95%CI 1.386～52.556)、5.346(95%CI，1.069～26.738)。结论 卵巢癌合并2型糖尿病的发生发展受多种因素相互作用的影响。积极治疗盆腔囊肿和高脂血症，可预防和控制卵巢癌合并2型糖尿病的发生发展。
关键词：卵巢癌;糖尿病;高血压;血脂
中图分类号：R581.1;R737131 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.05.039
, 百拇医药
文章编号：1006-1959(2019)05-0124-02
Abstract：Objective To study the risk factors of ovarian cancer with type 2 diabetes. Methods From January 2010 to December 2017，21 patients were diagnosed with ovarian cancer complicated with type 2 diabetes as case group， 47 patients were diagnosed with ovarian cancer without type 2 diabetes as control group.The clinical data of the patients were collected， including general condition， birth history， menstrual history， contraceptive history， family history and past history， and unconditional logistic regression analysis was used. Results Univariate analysis showed that hypertension， pelvic cysts and hyperlipidemia were risk factors for ovarian cancer with type 2 diabetes. Multivariate analysis showed that ovarian cancer with type 2 diabetes was significantly associated with pelvic cysts and hyperlipidemia， with OR values of 8.536 (95% CI 1.386 to 52.556) and 5.346 (95% CI， 1.069 to 26.738)， respectively. Conclusion The occurrence and development of ovarian cancer with type 2 diabetes is affected by the interaction of various factors. Active treatment of pelvic cysts and hyperlipidemia can prevent and control the occurrence and development of ovarian cancer with type 2 diabetes.
, http://www.100md.com
Key words：Ovarian cancer;Diabetes;Hypertension;Blood lipids
卵巢癌(ovarian cancer)是女性生殖系統常见的恶性肿瘤之一，近期我国卵巢癌发病率呈上升趋势。卵巢癌死亡率占各类妇科肿瘤的首位[1]，严重威胁妇女健康和生命。近年来很多研究将糖尿病，尤其是2型糖尿病，与癌症发生率升高联系在一起[2-4]。流行病学调查提示糖尿病可增加癌症患病风险，这与疾病潜在的代谢紊乱相关[5]。本研究收集2010年1月～2017年12月三峡大学人民医院卵巢癌患者的临床资料，对可能影响卵巢癌合并2型糖尿病发病的危险因素进行深入分析。
1资料与方法
1.1一般资料 将2010年1月～2017年12月三峡大学人民医院收治的出院主诊断为卵巢癌合并2型糖尿病患者21例设为病例组，另选取同期未合并糖尿病的卵巢癌患者47例作为对照组。病例组年龄42～72岁，平均年龄(55.90±9.88)岁;对照组年龄 33～77岁，平均年龄(53.98±10.95)岁。两组患者年龄比较无统计学差异(P>0.05)。纳入患者的病理诊断确诊，住院 、手术和检查记录完整，均未合并其他类型的肿瘤，非转移性癌，未妊娠。, http://www.100md.com(林斯婕 吴璇 覃桓 余立萍)
关键词：卵巢癌;糖尿病;高血压;血脂
中图分类号：R581.1;R737131 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.05.039
, 百拇医药
文章编号：1006-1959(2019)05-0124-02
Abstract：Objective To study the risk factors of ovarian cancer with type 2 diabetes. Methods From January 2010 to December 2017，21 patients were diagnosed with ovarian cancer complicated with type 2 diabetes as case group， 47 patients were diagnosed with ovarian cancer without type 2 diabetes as control group.The clinical data of the patients were collected， including general condition， birth history， menstrual history， contraceptive history， family history and past history， and unconditional logistic regression analysis was used. Results Univariate analysis showed that hypertension， pelvic cysts and hyperlipidemia were risk factors for ovarian cancer with type 2 diabetes. Multivariate analysis showed that ovarian cancer with type 2 diabetes was significantly associated with pelvic cysts and hyperlipidemia， with OR values of 8.536 (95% CI 1.386 to 52.556) and 5.346 (95% CI， 1.069 to 26.738)， respectively. Conclusion The occurrence and development of ovarian cancer with type 2 diabetes is affected by the interaction of various factors. Active treatment of pelvic cysts and hyperlipidemia can prevent and control the occurrence and development of ovarian cancer with type 2 diabetes.
, http://www.100md.com
Key words：Ovarian cancer;Diabetes;Hypertension;Blood lipids
卵巢癌(ovarian cancer)是女性生殖系統常见的恶性肿瘤之一，近期我国卵巢癌发病率呈上升趋势。卵巢癌死亡率占各类妇科肿瘤的首位[1]，严重威胁妇女健康和生命。近年来很多研究将糖尿病，尤其是2型糖尿病，与癌症发生率升高联系在一起[2-4]。流行病学调查提示糖尿病可增加癌症患病风险，这与疾病潜在的代谢紊乱相关[5]。本研究收集2010年1月～2017年12月三峡大学人民医院卵巢癌患者的临床资料，对可能影响卵巢癌合并2型糖尿病发病的危险因素进行深入分析。
1资料与方法
1.1一般资料 将2010年1月～2017年12月三峡大学人民医院收治的出院主诊断为卵巢癌合并2型糖尿病患者21例设为病例组，另选取同期未合并糖尿病的卵巢癌患者47例作为对照组。病例组年龄42～72岁，平均年龄(55.90±9.88)岁;对照组年龄 33～77岁，平均年龄(53.98±10.95)岁。两组患者年龄比较无统计学差异(P>0.05)。纳入患者的病理诊断确诊，住院 、手术和检查记录完整，均未合并其他类型的肿瘤，非转移性癌，未妊娠。, http://www.100md.com(林斯婕 吴璇 覃桓 余立萍)