肿瘤标志物和凝血指标在肺癌辅助诊断中的效果分析(1)
摘要：目的 探析肺癌辅助诊断中肿瘤标志物与凝血指标的诊断价值。方法 将2016年2月～2018年11月我院收治的48例肺癌患者纳入研究组，将同期48例健康体检人员纳入对照组，通过电化学发光仪和全自动血凝分析仪检测患者肿瘤标志物和凝血指标，肿瘤标志物包括鳞状细胞癌相关抗原(SCC)、癌胚抗原(CEA)、细胞角蛋白19(CYFRA21-1)和神经元特异性烯醇化酶(NSE);凝血指标包括D-二聚体(D-dimer)、纤维蛋白原(FIB)、活血部分凝血活酶时间(APTT)、凝血酶时间(TT)及血浆凝血酶原时间(PT)。结果 在SCC、CYFRA21-1、CEA及NSE方面，研究组均高于对照组，差异存在统计学意义(P<0.05);研究组TT低于对照组，而D-dimer、FIB高于对照组，差异均有统计学意义(P<0.05);两组APTT及PT分别比较，差异均无统计学意义(P>0.05)。结论 根据CEA、CYFRA21-1、NSE及FIB指标水平，有助于肺癌疾病诊断准确率的提高，根据肿瘤标志物及凝血指标数值，有助于判断肺癌发展状况。
, 百拇医药 关键词：肺癌;凝血指标;肿瘤标志物
中图分类号：R734.2;R730.43 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.07.053
文章编号：1006-1959(2019)07-0168-02
Abstract：Objective To investigate the diagnostic value of tumor markers and coagulation parameters in the diagnosis of lung cancer. Methods 48 patients with lung cancer admitted to our hospital from February 2016 to November 2018 were enrolled in the study group. 48 healthysubjects were included in the control group， and the tumor markers were detected by electrochemiluminescence and automatic hemagglutination analyzer. And coagulation indicators， tumor markers including squamous cell carcinoma associated antigen (SCC)， carcinoembryonic antigen (CEA)， cytokeratin 19 (CYFRA21-1) and neuron specific enolase (NSE); coagulation indicators include D-dimer， fibrinogen (FIB)， viable partial thromboplastin time (APTT)， thrombin time (TT)， and plasma prothrombin time (PT). Results In the SCC， CYFRA21-1， CEA and NSE， the study group was higher than the control group， the difference was statistically significant (P<0.05); the study group TT was higher than the control group， and the D-dimer was lower than the control group， the difference All of them were statistically significant (P<0.05). There were no significant differences in APTT and PT between the two groups (P>0.05). Conclusion According to CEA， CYFRA21-1， NSE and FIB levels， it can help to improve the accuracy of lung cancer diagnosis. According to the tumor markers and coagulation index values， it can help to judge the development of lung cancer.
Key words：Lung cancer;Coagulation index;Tumor markers
肺癌(lung cancer)已經发展成为导致全球恶性肿瘤死亡的首要因素。据有关资料显示[1]，我国肺癌患者5年生存率已经降低大约9.1%。肺癌疾病发病隐匿，通常诊断时已经发展为晚期。因此，及早诊断和治疗尤为重要。常规诊断和治疗通常根据血清肿瘤标志物进行判断，其被视为监测疾病治疗、诊断预后和评估的主要方法。相关研究表明[2]，恶性肿瘤复发、生长、转移及心血管形成期间，血压高凝具有重要作用。本次研究主要针对肿瘤标志物及凝血指标在肺癌辅助诊断中的应用效果进行探析，现报告如下。, 百拇医药(杨寿林 宋庆志 吴路发)
, 百拇医药 关键词：肺癌;凝血指标;肿瘤标志物
中图分类号：R734.2;R730.43 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.07.053
文章编号：1006-1959(2019)07-0168-02
Abstract：Objective To investigate the diagnostic value of tumor markers and coagulation parameters in the diagnosis of lung cancer. Methods 48 patients with lung cancer admitted to our hospital from February 2016 to November 2018 were enrolled in the study group. 48 healthysubjects were included in the control group， and the tumor markers were detected by electrochemiluminescence and automatic hemagglutination analyzer. And coagulation indicators， tumor markers including squamous cell carcinoma associated antigen (SCC)， carcinoembryonic antigen (CEA)， cytokeratin 19 (CYFRA21-1) and neuron specific enolase (NSE); coagulation indicators include D-dimer， fibrinogen (FIB)， viable partial thromboplastin time (APTT)， thrombin time (TT)， and plasma prothrombin time (PT). Results In the SCC， CYFRA21-1， CEA and NSE， the study group was higher than the control group， the difference was statistically significant (P<0.05); the study group TT was higher than the control group， and the D-dimer was lower than the control group， the difference All of them were statistically significant (P<0.05). There were no significant differences in APTT and PT between the two groups (P>0.05). Conclusion According to CEA， CYFRA21-1， NSE and FIB levels， it can help to improve the accuracy of lung cancer diagnosis. According to the tumor markers and coagulation index values， it can help to judge the development of lung cancer.
Key words：Lung cancer;Coagulation index;Tumor markers
肺癌(lung cancer)已經发展成为导致全球恶性肿瘤死亡的首要因素。据有关资料显示[1]，我国肺癌患者5年生存率已经降低大约9.1%。肺癌疾病发病隐匿，通常诊断时已经发展为晚期。因此，及早诊断和治疗尤为重要。常规诊断和治疗通常根据血清肿瘤标志物进行判断，其被视为监测疾病治疗、诊断预后和评估的主要方法。相关研究表明[2]，恶性肿瘤复发、生长、转移及心血管形成期间，血压高凝具有重要作用。本次研究主要针对肿瘤标志物及凝血指标在肺癌辅助诊断中的应用效果进行探析，现报告如下。, 百拇医药(杨寿林 宋庆志 吴路发)