百日咳综合征患儿潮气呼吸肺功能变化情况及临床指导意义(1)
摘要：目的 研究百日咳综合征患儿潮气呼吸肺功能的变化情况，探讨其临床指导意义。方法 收集2018年3月～9月在我科住院的百日咳综合征患兒115例作为观察组，同龄健康儿童50例作为对照组，对两组儿童进行潮气呼吸肺功能测定。结果 观察组患儿每公斤体重潮气量(VT/kg)、吸呼比(TI/TE)、达峰时间比(TPTEF/TE)、达峰容积比(VPEF/VE)分别为(8.39±1.21)ml/kg，(0.69±0.10)%，(21.01±5.09)%，(22.30±4.61)%，低于对照组的(9.05±1.01)ml/kg，(0.82±0.12)%，(39.68±10.21)%，(39.31±9.96)%，呼吸频率(RR)为(28.76±5.77)次/min，高于对照组的(24.56±5.45)次/min，差异具有统计学意义(P<0.05)。结论 百日咳综合征患儿大小气道通气功能均有损害，表现在安静状态下的肺功能检查差异，由此可以了解损伤程度，并指导临床治疗及用药，以及评估疗效和预后都有一定意义。
关键词：肺功能;潮气呼吸肺功能;百日咳综合征;儿童
, 百拇医药
中图分类号：R725.6 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.10.037
文章编号：1006-1959(2019)10-0114-03
Abstract：Objective To study the changes of tidal breathing and pulmonary function in children with pertussis syndrome， and to explore its clinical significance. Methods A total of 115 children with pertussis syndrome admitted to our department from March to September 2018 were enrolled in the observation group. 50 healthy children of the same age were used as the control group. The tidal breathing pulmonary function was measured in the two groups. Results In the observation group， the tidal volume (VT/kg)， the specific respiratory rate (TI/TE)， the peak-to-peak ratio (TPTEF/TE)， and the peak volume ratio (VPEF/VE) per kilogram of body weight were (8.39±1.21)ml/kg， (0.69±0.10)%， (21.01±5.09)%， (22.30±4.61)%， lower than the control group (9.05±1.01)ml/kg， (0.82±0.12)%， (39.68± 10.21)%， (39.31±9.96)%， respiratory rate (RR) was (28.76±5.77) times/min， which was higher than that of the control group (24.56±5.45) times/min， the difference was statistically significant(P<0.05).Conclusion The size of airway ventilation in children with pertussis syndrome is impaired. The difference in lung function tests in quiet state can be used to understand the extent of injury， and to guide clinical treatment and medication， as well as to evaluate the efficacy and prognosis.
, 百拇医药
Key words：Pulmonary function;Tidal breathing pulmonary function;Pertussis syndrome;Children
百日咳综合征(pertussis syndrome)是一类症候群，是与百日咳非常相似的病症，其病因目前尚不是十分明确，又称“类百日咳”，近年来呈高发趋势。它不是由百日咳杆菌感染引起，而是由包括病毒感染在内的其他微生物感染所致。临床上以发作性痉挛性咳嗽、咳嗽末伴高音调鸡鸣样回声为特征[1]。表现为每天咳嗽数十余次，呈痉挛样，夜间明显，每次连续咳嗽数声后伴面色憋红或发绀、流泪、少数发生窒息，痉挛性咳嗽后伴一次深长吸气，部分患儿可咳出少量黏稠痰液或泡沫痰，痉咳间歇期患儿一般情况好。致病菌最常见的为腺病毒，其他有流感嗜血杆菌、肺炎支原体、呼吸道合胞病毒等。肺功能检测能为呼吸系统疾病病变部位的诊断、疾病严重程度的判断、疗效评估、预后预测及发病机制的探讨提供客观依据[2]。本研究通过对2018年3月～9月在成都市妇女儿童中心医院儿童呼吸科住院的百日咳综合征患儿115例进行肺功能检测，了解百日咳综合征患儿的潮气呼吸肺功能变化情况，指导临床用药及评估预后。, http://www.100md.com(陶沛 艾涛 樊映红 罗荣华 段亚平)
关键词：肺功能;潮气呼吸肺功能;百日咳综合征;儿童
, 百拇医药
中图分类号：R725.6 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.10.037
文章编号：1006-1959(2019)10-0114-03
Abstract：Objective To study the changes of tidal breathing and pulmonary function in children with pertussis syndrome， and to explore its clinical significance. Methods A total of 115 children with pertussis syndrome admitted to our department from March to September 2018 were enrolled in the observation group. 50 healthy children of the same age were used as the control group. The tidal breathing pulmonary function was measured in the two groups. Results In the observation group， the tidal volume (VT/kg)， the specific respiratory rate (TI/TE)， the peak-to-peak ratio (TPTEF/TE)， and the peak volume ratio (VPEF/VE) per kilogram of body weight were (8.39±1.21)ml/kg， (0.69±0.10)%， (21.01±5.09)%， (22.30±4.61)%， lower than the control group (9.05±1.01)ml/kg， (0.82±0.12)%， (39.68± 10.21)%， (39.31±9.96)%， respiratory rate (RR) was (28.76±5.77) times/min， which was higher than that of the control group (24.56±5.45) times/min， the difference was statistically significant(P<0.05).Conclusion The size of airway ventilation in children with pertussis syndrome is impaired. The difference in lung function tests in quiet state can be used to understand the extent of injury， and to guide clinical treatment and medication， as well as to evaluate the efficacy and prognosis.
, 百拇医药
Key words：Pulmonary function;Tidal breathing pulmonary function;Pertussis syndrome;Children
百日咳综合征(pertussis syndrome)是一类症候群，是与百日咳非常相似的病症，其病因目前尚不是十分明确，又称“类百日咳”，近年来呈高发趋势。它不是由百日咳杆菌感染引起，而是由包括病毒感染在内的其他微生物感染所致。临床上以发作性痉挛性咳嗽、咳嗽末伴高音调鸡鸣样回声为特征[1]。表现为每天咳嗽数十余次，呈痉挛样，夜间明显，每次连续咳嗽数声后伴面色憋红或发绀、流泪、少数发生窒息，痉挛性咳嗽后伴一次深长吸气，部分患儿可咳出少量黏稠痰液或泡沫痰，痉咳间歇期患儿一般情况好。致病菌最常见的为腺病毒，其他有流感嗜血杆菌、肺炎支原体、呼吸道合胞病毒等。肺功能检测能为呼吸系统疾病病变部位的诊断、疾病严重程度的判断、疗效评估、预后预测及发病机制的探讨提供客观依据[2]。本研究通过对2018年3月～9月在成都市妇女儿童中心医院儿童呼吸科住院的百日咳综合征患儿115例进行肺功能检测，了解百日咳综合征患儿的潮气呼吸肺功能变化情况，指导临床用药及评估预后。, http://www.100md.com(陶沛 艾涛 樊映红 罗荣华 段亚平)