影响PCNL术后出血栓塞治疗的主要因素分析(3)
本研究结果显示,两组患者的人口学资料、结石类型、手术相关因素、术前血红蛋白水平、出血天数、输血量比较,差异无统计学意义(P>0.05)。出血相关因素中,栓塞组Hb下降值大于保守治疗组[(44.08±11.86)g/L vs (19.05±12.72)g/L],输血比例高于保守治疗组(8/12 vs 6/40),差异具有统计学意义(P<0.05),考虑出血相关因素与栓塞可能有一定关系。基于以上结果,我们将Hb下降值、出血天数以及是否输血纳入多变量Logistic回归分析中。Un S等[12]也对栓塞患者与保守治疗患者的基本资料及出血相关因素进行了分析,并发现两组的Hb下降值、出血天数、输血量有显著性差异,这与本研究的结果相似,但是并没有进一步行回归分析来确定这些因素与栓塞之间的相关性。本研究多变量Logistic回归分析结果显示,Hb下降值为决定PCNL术后出血是否栓塞的重要因素(OR=1.142,95%CI 1.038~1.256,P=0.006)。
综上所述,对于PCNL术后出血的患者,Hb下降值为决定是否栓塞的重要因素,在决定是否行栓塞治疗时应充分考虑Hb下降的程度,对于Hb下降程度大的患者应该及时行栓塞止血。本研究确定了Hb下降值为决定栓塞的重要因素,但还需进行多中心大样本研究监测PCNL术后患者血色素变化情况,以确定具体的Hb下降值为临床栓塞治疗提供指导。
, 百拇医药
参考文献:
[1]张智,秦卫军,袁建林,等.經皮肾镜碎石取石术严重出血的相关因素分析[J].中华腔镜泌尿外科杂志(电子版),2018,12(3):194-198.
[2]那彦群,叶张群,孙颖浩,等.中国泌尿外科疾病诊断治疗指南[M].北京:人民卫生出版社,2014:281-282.
[3]Mithani MH,Khan SA,Khalid SE,et al.Predictive Factors for Intraoperative Blood Loss during Percutaneous Nephrolithotomy[J].J Coll Physicians Surg Pak,2018,28(8):623-627.
[4]Arora AM,Pawar PW,Tamhankar AS,et al.Predictors for severe hemorrhage requiring angioembolization post percutaneous nephrolithotomy:A single-center experience over 3 years[J].Urology Annals,2019,11(2):180.
, 百拇医药
[5]Xu B,Hu J,Chen A,et al.Risk Factors Related with Retroperitoneal Laparoscopic Converted to Open Nephrectomy for Nonfunctioning Renal Tuberculosis[J].Journal of Endourology,2017,31(6):588-592.
[6]Chakraborty JN,Hatimota P.Same-day angiography and embolization in delayed hematuria following percutaneous nephrolithotomy:an effective,safe,and time-saving approach[J].Research and Reports in Urology,2019(11):83-89.
[7]Jalal A,Ahmadi A,Mubarak M,et al.Percutaneous nephrolithotomy of a staghorn calculus in a patient with renal angiomyolipoma[J].Urology Annals,2019,11(2):229.
, http://www.100md.com
[8]汪金荣,蒋志强,仇向东,等.经皮肾镜取石术并发大出血的分类与治疗[J].中国内镜杂志,2014,20(2):209-211.
[9]Li L,Zhang Y,Chen Y,et al.Amulticentre retrospective study of transcatheter angiographic embolization in the treatment of delayed haemorrhage after percutaneous nephrolithotomy[J].European Radiology,2015,25(4):1140-1147.
[10]Mohammadi M,Nouri-Mahdavi K,Barzegar A.Effects of Tranexamic Acid on Bleeding and Hemoglobin Levels in Patients with Staghorn Calculi Undergoing Percutaneous Nephrolithotomy:Randomized Controlled Trial[J].Iranian Journal of Medical Sciences,2019.
, 百拇医药
[11]Eleswarapu SV,Leavitt DA.Hemorrhagic Complications Associated with Percutaneous Nephrolithotomy[J].Smith's Textbook of Endourology,2018(12):397-408.
[12]Un S,Cakir V,Kara C,et al.Risk factors for hemorrhage requiring embolization after percutaneous nephrolithotomy[J].Canadian Urological Association Journal,2015,9(9-10):E594-E598.
收稿日期:2019-4-19;修回日期:2019-4-26
编辑/张建婷, 百拇医药(冉瑞图 苏帅 唐先圣)
综上所述,对于PCNL术后出血的患者,Hb下降值为决定是否栓塞的重要因素,在决定是否行栓塞治疗时应充分考虑Hb下降的程度,对于Hb下降程度大的患者应该及时行栓塞止血。本研究确定了Hb下降值为决定栓塞的重要因素,但还需进行多中心大样本研究监测PCNL术后患者血色素变化情况,以确定具体的Hb下降值为临床栓塞治疗提供指导。
, 百拇医药
参考文献:
[1]张智,秦卫军,袁建林,等.經皮肾镜碎石取石术严重出血的相关因素分析[J].中华腔镜泌尿外科杂志(电子版),2018,12(3):194-198.
[2]那彦群,叶张群,孙颖浩,等.中国泌尿外科疾病诊断治疗指南[M].北京:人民卫生出版社,2014:281-282.
[3]Mithani MH,Khan SA,Khalid SE,et al.Predictive Factors for Intraoperative Blood Loss during Percutaneous Nephrolithotomy[J].J Coll Physicians Surg Pak,2018,28(8):623-627.
[4]Arora AM,Pawar PW,Tamhankar AS,et al.Predictors for severe hemorrhage requiring angioembolization post percutaneous nephrolithotomy:A single-center experience over 3 years[J].Urology Annals,2019,11(2):180.
, 百拇医药
[5]Xu B,Hu J,Chen A,et al.Risk Factors Related with Retroperitoneal Laparoscopic Converted to Open Nephrectomy for Nonfunctioning Renal Tuberculosis[J].Journal of Endourology,2017,31(6):588-592.
[6]Chakraborty JN,Hatimota P.Same-day angiography and embolization in delayed hematuria following percutaneous nephrolithotomy:an effective,safe,and time-saving approach[J].Research and Reports in Urology,2019(11):83-89.
[7]Jalal A,Ahmadi A,Mubarak M,et al.Percutaneous nephrolithotomy of a staghorn calculus in a patient with renal angiomyolipoma[J].Urology Annals,2019,11(2):229.
, http://www.100md.com
[8]汪金荣,蒋志强,仇向东,等.经皮肾镜取石术并发大出血的分类与治疗[J].中国内镜杂志,2014,20(2):209-211.
[9]Li L,Zhang Y,Chen Y,et al.Amulticentre retrospective study of transcatheter angiographic embolization in the treatment of delayed haemorrhage after percutaneous nephrolithotomy[J].European Radiology,2015,25(4):1140-1147.
[10]Mohammadi M,Nouri-Mahdavi K,Barzegar A.Effects of Tranexamic Acid on Bleeding and Hemoglobin Levels in Patients with Staghorn Calculi Undergoing Percutaneous Nephrolithotomy:Randomized Controlled Trial[J].Iranian Journal of Medical Sciences,2019.
, 百拇医药
[11]Eleswarapu SV,Leavitt DA.Hemorrhagic Complications Associated with Percutaneous Nephrolithotomy[J].Smith's Textbook of Endourology,2018(12):397-408.
[12]Un S,Cakir V,Kara C,et al.Risk factors for hemorrhage requiring embolization after percutaneous nephrolithotomy[J].Canadian Urological Association Journal,2015,9(9-10):E594-E598.
收稿日期:2019-4-19;修回日期:2019-4-26
编辑/张建婷, 百拇医药(冉瑞图 苏帅 唐先圣)