摘要：同型半胱氨酸(Hcy)是心血管疾病的独立危险因子之一。Hcy能够诱导细胞活性氧(ROS)的生成增多引起内皮损伤从而导致动脉粥样硬化(AS)发生发展。内皮细胞中ROS主要来源于Nox4(NADPH oxidases 4)。NLRP3在冠状动脉粥样硬化及主动脉硬化中高表达。NLRP3是AS中IL-1家族细胞因子产生的关键介质，特别是当细胞内产生的大量ROS，可导致caspase-1前体大量剪切成具有生物活性的caspase-1 P10片段，推动下游IL-1β和IL-18等炎症因子的成熟及分泌，使内皮细胞功能受损，引起细胞炎症损伤及凋亡，正反馈加重血管损伤。本文主要探讨Nox4在Hcy介导的内皮细胞炎癥及凋亡的作用，Hcy导致的AS提供可能的机制。

    关键词：同型半胱氨酸;动脉粥样硬化;Nox4;NLRP3

    中图分类号：R543.5 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.15.015

    文章编号：1006-1959(2019)15-0045-03

    Abstract：Homocysteine (Hcy) is one of the independent risk factors for cardiovascular disease. Hcy can induce the increase of cellular reactive oxygen species (ROS) to cause endothelial damage leading to the development of atherosclerosis (AS). ROS in endothelial cells are mainly derived from Nox4 (NADPH oxidases 4). NLRP3 is highly expressed in coronary atherosclerosis and aortic sclerosis. NLRP3 is a key mediator of IL-1 family cytokine production in AS ......