HLA基因及儿童期经历在抑郁障碍发病机制中的作用及其交互影响关系(3)
综上所述，HLA基因作为自身免疫的重要基因，对中枢神经系统的炎症敏感性及水平存在调节作用。这种作用可能通过影响TNF-α等细胞因子，来改变童年期虐待创伤的环境因素对于个体自身免疫水平的影响，从而影响个体对抑郁障碍的易感性，但这一交互作用的具体机制，有待进一步研究。
参考文献：
[1]Huang Y，Wang Y，Wang H，et al.Prevalence of mental disorders in China：a cross-sectional epidemiological study[J].The Lancet Psychiatry，2019，6(3)：211-224.
[2]WHO.Depression and Other Common Mental Disorders：Global Health Estimates[R].Geneva：World Health Organization，2017.
, 百拇医药
[3]Rutter M，Silberg J.Gene-Environment Interplay in Relation to Emotional and Behavioral Disturbance[J].European Psychiatry，2002，17(1)：13.
[4]Bobińska K，Galecka E，Szemraj J，et al.Is there a link between TNF gene expression and cognitive deficits in depression[J].Acta Biochimica Polonica，2017，64(1)：65-73.
[5]Hiles SA，Baker AL，Malmanche TD，et al.A meta-analysis of differences in IL-6 and IL-10 between people with and without depression：Exploring the causes of heterogeneity[J].Brain Behavior and Immunity，2012，26(7)：1180-1188.
, 百拇医药
[6]Genestier L，Paillot R，Bonnefoy-Berard N，et al.T cell sensitivity to HLA class I-mediated apoptosis is dependent on interleukin-2 and interleukin-4[J].European Journal of Immunology，2010，27(2)：495-499.
[7]Shimadasugimoto M，Otowa T，Miyagawa T，et al.Immune-related pathways including HLA-DRB1*13：02，are associated with panic disorder[J].Brain Behavior&Immunity，2015，46(1)：96-103.
[8]Stefansson H，Ophoff RA，Steinberg S，et al.Common variants conferring risk of schizophrenia[J].Nature，2009，460(7256)：744-747.
, http://www.100md.com
[9]Brucato N，Guadalup T，Franke B，et al.A schizophrenia-associated HLA locus affects thalamus volume and asymmetry[J].Brain，Behavior，and Immunity，2015，46(2)：311-318.
[10]Wang ZX，Wan Y，Tan L，et al.Genetic Association of HLA Gene Variants with MRI Brain Structure in Alzheimer's Disease[J].Molecular Neurobiology，2017，54(5)：3195-3204.
[11]Wang ZX，Wang HF，Tan L，et al.HLA-A2 Alleles Mediate Alzheimer's Disease by Altering Hippocampal Volume[J].Mol Neurobiol，2017，54(4)：2469-2476.
, 百拇医药
[12]蘇林雁.儿童期经历和精神疾病[J].中国神经精神疾病杂志，2014，40(10)：577-579.
[13]Miller AH，Raison CL.The role of inflammation in depression：from evolutionary imperative to modern treatment target[J].Nature Reviews Immunology，2015，16(1)：22-34.
[14]姚桂英，杜爱玲，杨世昌，等.人格在大学生童年期精神虐待与当前抑郁症状之间的中介作用[J].中国临床心理学杂志，2011，19(1)：66-68.
[15]Nanni V，Uher R，Danese A.Childhood Maltreatment Predicts Unfavorable Course of Illness and Treatment Outcome in Depression：A Meta-Analysis[J].American Journal of Psychiatry，2012，169(2)：141-151., 百拇医药(程怡欣 卢瑾)
参考文献：
[1]Huang Y，Wang Y，Wang H，et al.Prevalence of mental disorders in China：a cross-sectional epidemiological study[J].The Lancet Psychiatry，2019，6(3)：211-224.
[2]WHO.Depression and Other Common Mental Disorders：Global Health Estimates[R].Geneva：World Health Organization，2017.
, 百拇医药
[3]Rutter M，Silberg J.Gene-Environment Interplay in Relation to Emotional and Behavioral Disturbance[J].European Psychiatry，2002，17(1)：13.
[4]Bobińska K，Galecka E，Szemraj J，et al.Is there a link between TNF gene expression and cognitive deficits in depression[J].Acta Biochimica Polonica，2017，64(1)：65-73.
[5]Hiles SA，Baker AL，Malmanche TD，et al.A meta-analysis of differences in IL-6 and IL-10 between people with and without depression：Exploring the causes of heterogeneity[J].Brain Behavior and Immunity，2012，26(7)：1180-1188.
, 百拇医药
[6]Genestier L，Paillot R，Bonnefoy-Berard N，et al.T cell sensitivity to HLA class I-mediated apoptosis is dependent on interleukin-2 and interleukin-4[J].European Journal of Immunology，2010，27(2)：495-499.
[7]Shimadasugimoto M，Otowa T，Miyagawa T，et al.Immune-related pathways including HLA-DRB1*13：02，are associated with panic disorder[J].Brain Behavior&Immunity，2015，46(1)：96-103.
[8]Stefansson H，Ophoff RA，Steinberg S，et al.Common variants conferring risk of schizophrenia[J].Nature，2009，460(7256)：744-747.
, http://www.100md.com
[9]Brucato N，Guadalup T，Franke B，et al.A schizophrenia-associated HLA locus affects thalamus volume and asymmetry[J].Brain，Behavior，and Immunity，2015，46(2)：311-318.
[10]Wang ZX，Wan Y，Tan L，et al.Genetic Association of HLA Gene Variants with MRI Brain Structure in Alzheimer's Disease[J].Molecular Neurobiology，2017，54(5)：3195-3204.
[11]Wang ZX，Wang HF，Tan L，et al.HLA-A2 Alleles Mediate Alzheimer's Disease by Altering Hippocampal Volume[J].Mol Neurobiol，2017，54(4)：2469-2476.
, 百拇医药
[12]蘇林雁.儿童期经历和精神疾病[J].中国神经精神疾病杂志，2014，40(10)：577-579.
[13]Miller AH，Raison CL.The role of inflammation in depression：from evolutionary imperative to modern treatment target[J].Nature Reviews Immunology，2015，16(1)：22-34.
[14]姚桂英，杜爱玲，杨世昌，等.人格在大学生童年期精神虐待与当前抑郁症状之间的中介作用[J].中国临床心理学杂志，2011，19(1)：66-68.
[15]Nanni V，Uher R，Danese A.Childhood Maltreatment Predicts Unfavorable Course of Illness and Treatment Outcome in Depression：A Meta-Analysis[J].American Journal of Psychiatry，2012，169(2)：141-151., 百拇医药(程怡欣 卢瑾)