红细胞分布宽度在卒中后抑郁患者血清中的变化及与炎症因子的关系(1)
摘要：目的 探究红细胞分布宽度(RDW)在卒中后抑郁(PSD)患者血清中的变化情况及与炎症因子的关系。方法 选取2018年10月～2019年4月我院收治的首发缺血性脑卒中患者90例，按照汉密尔顿抑郁量表(HAMD)评估法分为PSD组(38例)和非PSD组(52例)，比较两组临床资料，并分析PSD与HAMD相关性及RDW与PSD发生风险及炎症因子间的关系。结果 两组年龄、高血压史、糖尿病史、Hb、MCHC、RDW、MCV比较，差异无统计学意义(P>0.05);两组性别、RBC、MCH、IL-6、TNF-α、IL-10比较，差异有统计学意义(P<0.05)。IL-6、TNF-α与HAMD评分呈正相关(r=0.323、0.329，P<0.05)。Logistic回归分析显示，IL-6和TNF-α是PSD发生的危险因素。PSD组RDW与IL-6呈正相关(r=0.457，P<0.05)。结论 IL-6和TNF是PSD发生的危险因素，RDW可能通过介导炎症机制参与PSD的发生。
关键词：红细胞分布宽度;卒中后抑郁;炎症因子
, 百拇医药
中图分类号：R749.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.16.024
文章编号：1006-1959(2019)16-0080-04
Abstract：Objective To investigate the changes of red blood cell distribution width (RDW) in serum of patients with post-stroke depression (PSD) and its relationship with inflammatory factors. Methods A total of 90 patients with first ischemic stroke admitted to our hospital from October 2018 to April 2019 were enrolled. According to the Hamilton Depression Scale (HAMD) assessment， they were divided into PSD group (38 cases) and non-PSD group (52 cases)， compare the clinical data of the two groups， and analyze the relationship between PSD and HAMD and the relationship between RDW and PSD risk and inflammatory factors. Results There were no significant differences in age， history of hypertension， history of diabetes， Hb， MCHC， RDW and MCV between the two groups (P>0.05). Gender， RBC， MCH， IL-6， TNF-α， IL-10 The difference was statistically significant (P< 0.05). IL-6 and TNF-α were positively correlated with the HAMD score (r=0.323，0.329， P< 0.05). Logistic regression analysis showed that IL-6 and TNF-α were risk factors for PSD. RDW in the PSD group was positively correlated with IL-6 (r=0.457， P< 0.05).Conclusion IL-6 and TNF are risk factors for PSD. RDW may participate in the development of PSD through mediating inflammation.
, 百拇医药
Key words：Red blood cell distribution width;Post-stroke depression;Inflammatory factors
腦卒中(stroke)指由于脑部血管突然破裂或因血管阻塞致血液不能流入大脑而引起脑组织损伤的一种疾病。约1/3的脑卒中幸存者表现有临床抑郁[1]，但由于起病隐匿、临床医生重视不足，漏诊率较高，早期正确的评估、筛查、干预对患者预后意义重大[2]。炎性细胞因子参与抑郁症的发病机制得到广泛认可[3];诸多炎性因子中，lL-6、TNF-α、IL-10被研究最多且最为关键。红细胞分布宽度(red blood cell distribution width，RDW)是反映外周血红细胞体积异质性的参数，为区分不同类型的贫血提供一定的参考价值。近来，升高的RDW被指出与多种疾病的预后和活动性有关[4-7]，包括脑卒中[8]。尽管确切机制尚未被充分认知，但RDW在炎症性疾病中的升高提供了有力佐证[7，9]。RDW作为一种被新认识的炎性标志物，其在卒中后抑郁(post-stroke depression，PSD)患者中的变化及病理生理中扮演的角色尚不得而知。本研究旨在探究RDW在PSD患者血清中的变化情况及其与炎症因子的关系，以期能对PSD早期的识别、诊断做出贡献。, http://www.100md.com(尚波 金菁)
关键词：红细胞分布宽度;卒中后抑郁;炎症因子
, 百拇医药
中图分类号：R749.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.16.024
文章编号：1006-1959(2019)16-0080-04
Abstract：Objective To investigate the changes of red blood cell distribution width (RDW) in serum of patients with post-stroke depression (PSD) and its relationship with inflammatory factors. Methods A total of 90 patients with first ischemic stroke admitted to our hospital from October 2018 to April 2019 were enrolled. According to the Hamilton Depression Scale (HAMD) assessment， they were divided into PSD group (38 cases) and non-PSD group (52 cases)， compare the clinical data of the two groups， and analyze the relationship between PSD and HAMD and the relationship between RDW and PSD risk and inflammatory factors. Results There were no significant differences in age， history of hypertension， history of diabetes， Hb， MCHC， RDW and MCV between the two groups (P>0.05). Gender， RBC， MCH， IL-6， TNF-α， IL-10 The difference was statistically significant (P< 0.05). IL-6 and TNF-α were positively correlated with the HAMD score (r=0.323，0.329， P< 0.05). Logistic regression analysis showed that IL-6 and TNF-α were risk factors for PSD. RDW in the PSD group was positively correlated with IL-6 (r=0.457， P< 0.05).Conclusion IL-6 and TNF are risk factors for PSD. RDW may participate in the development of PSD through mediating inflammation.
, 百拇医药
Key words：Red blood cell distribution width;Post-stroke depression;Inflammatory factors
腦卒中(stroke)指由于脑部血管突然破裂或因血管阻塞致血液不能流入大脑而引起脑组织损伤的一种疾病。约1/3的脑卒中幸存者表现有临床抑郁[1]，但由于起病隐匿、临床医生重视不足，漏诊率较高，早期正确的评估、筛查、干预对患者预后意义重大[2]。炎性细胞因子参与抑郁症的发病机制得到广泛认可[3];诸多炎性因子中，lL-6、TNF-α、IL-10被研究最多且最为关键。红细胞分布宽度(red blood cell distribution width，RDW)是反映外周血红细胞体积异质性的参数，为区分不同类型的贫血提供一定的参考价值。近来，升高的RDW被指出与多种疾病的预后和活动性有关[4-7]，包括脑卒中[8]。尽管确切机制尚未被充分认知，但RDW在炎症性疾病中的升高提供了有力佐证[7，9]。RDW作为一种被新认识的炎性标志物，其在卒中后抑郁(post-stroke depression，PSD)患者中的变化及病理生理中扮演的角色尚不得而知。本研究旨在探究RDW在PSD患者血清中的变化情况及其与炎症因子的关系，以期能对PSD早期的识别、诊断做出贡献。, http://www.100md.com(尚波 金菁)