尿蛋白/肌酐、24h尿蛋白及肾功能指标检测在慢性肾病诊断中的价值(1)
摘要：目的 探讨检测尿蛋白/肌酐(Up/Cr)、24h尿蛋白(24h Up)及肾功能检测在慢性肾病诊断中的价值。方法 选取2017年9月～2018年12月我院收治的慢性肾病患者526例，根据肌酐清除率(Ccr)分为肾功能正常组100例、轻度损害组105例、中度损害组105例、重度损害组108例和尿毒症组108例。比较五组血肌酐(Scr)、Up/Cr、24h Up水平，并分析Up/Cr和24h Up的相关性。结果 中度、重度损害组和尿毒症组Scr高于肾功能正常组和轻度损害组，差异有统计学意义(P<0.05);肾功能正常组和轻度损害组Scr比较，差异无统计学意义(P>0.05)。轻度、中度、重度损害组、尿毒症组Up/Cr高于肾功能正常组，轻度、中度、重度损害组、尿毒症组24h Up高于肾功能正常组，差异有统计学意义(P<0.05)。肾功能正常组、轻度损害组、中度损害组和重度损害组Up/Cr和24h Up有相关性(P<0.05);尿毒症组Up/Cr和24h Up无相关性(P>0.05)。结论 UP/Cr和24h UP早期诊断慢性肾病效果优于Scr，当Ccr超过了10 ml/min时，其可用于临床慢性肾病的早期筛检。
, 百拇医药
关键词：尿蛋白/肌酐;24h尿蛋白;慢性肾病;肾功能
Abstract：Objective To investigate the value of urine protein/creatinine (Up/Cr)， 24h urine protein (24h Up) and renal function test in the diagnosis of chronic kidney disease.Methods A total of 526 patients with chronic kidney disease admitted to our hospital from September 2017 to December 2018 were enrolled. According to creatinine clearance rate (Ccr)， there were 100 patients with normal renal function， 105 patients with mild injury， and 105 patients with moderate damage. 108 patients in the severe injury group and 108 patients in the uremic group. 5 groups of serum creatinine (Scr)， Up/Cr， and 24h Up levels were compared， and the correlation between Up/Cr and 24h Up was analyzed. Results The Scr of the moderate， severe injury group and uremic group was higher than that of the normal renal function group and the mild damage group(P<0.05). There was no significant difference in the Scr between the normal renal function group and the mild injury group (P>0.05). In the mild， moderate， severe lesion groups and the uremia group， the Up/Cr group was higher than the normal renal function group; mild， moderate， severe injury groups， uremia group 24h Up was higher than normal renal function group， the highest in the moderate damage group， the difference was statistically significant (P<0.05). There was a correlation between Up/Cr and 24h Up in the normal renal function group， mild， moderate group and the severe damage groups (P<0.05). There was no correlation between Up/Cr and 24h Up in the uremic group (P>0.05).Conclusion The early diagnosis of chronic kidney disease by UP/Cr and 24h UP is better than Scr. When Ccr exceeds 10 ml/min， it can be used for early screening of clinical chronic kidney disease.
, 百拇医药
Key words：Urinary protein/creatinine;24h urine protein;Chronic kidney disease;Renal function
慢性肾病是一种发病率和患病率较高的疾病，患病率为10.8%[1];其具有起病隐匿和早期症状不典型的特点，多数患者在确诊时病情已较为严重，因此尽早发现病变并进行干预，可延缓疾病进展。临床上，血肌酐(Scr)是评价肾功能的重要指标，但是评价肾功能时的准确度和及时性不高[2]。尿蛋白(Up)异常增多是评价肾功能损害的重要指标，而诊断病理性蛋白尿的金标准为24小时尿蛋白(24h Up)定量，但存在患者依从性差和膀胱不完全排空等问题，影响结果的准确性。研究报道，Up/Cr可以作为评价肾功能早期损害的指标，且准确度较高[3]。本研究主要探讨Up/Cr、Up及肾功能指标检测在慢性肾病诊断中的价值，现報道如下。, 百拇医药(陈吉虎)
, 百拇医药
关键词：尿蛋白/肌酐;24h尿蛋白;慢性肾病;肾功能
Abstract：Objective To investigate the value of urine protein/creatinine (Up/Cr)， 24h urine protein (24h Up) and renal function test in the diagnosis of chronic kidney disease.Methods A total of 526 patients with chronic kidney disease admitted to our hospital from September 2017 to December 2018 were enrolled. According to creatinine clearance rate (Ccr)， there were 100 patients with normal renal function， 105 patients with mild injury， and 105 patients with moderate damage. 108 patients in the severe injury group and 108 patients in the uremic group. 5 groups of serum creatinine (Scr)， Up/Cr， and 24h Up levels were compared， and the correlation between Up/Cr and 24h Up was analyzed. Results The Scr of the moderate， severe injury group and uremic group was higher than that of the normal renal function group and the mild damage group(P<0.05). There was no significant difference in the Scr between the normal renal function group and the mild injury group (P>0.05). In the mild， moderate， severe lesion groups and the uremia group， the Up/Cr group was higher than the normal renal function group; mild， moderate， severe injury groups， uremia group 24h Up was higher than normal renal function group， the highest in the moderate damage group， the difference was statistically significant (P<0.05). There was a correlation between Up/Cr and 24h Up in the normal renal function group， mild， moderate group and the severe damage groups (P<0.05). There was no correlation between Up/Cr and 24h Up in the uremic group (P>0.05).Conclusion The early diagnosis of chronic kidney disease by UP/Cr and 24h UP is better than Scr. When Ccr exceeds 10 ml/min， it can be used for early screening of clinical chronic kidney disease.
, 百拇医药
Key words：Urinary protein/creatinine;24h urine protein;Chronic kidney disease;Renal function
慢性肾病是一种发病率和患病率较高的疾病，患病率为10.8%[1];其具有起病隐匿和早期症状不典型的特点，多数患者在确诊时病情已较为严重，因此尽早发现病变并进行干预，可延缓疾病进展。临床上，血肌酐(Scr)是评价肾功能的重要指标，但是评价肾功能时的准确度和及时性不高[2]。尿蛋白(Up)异常增多是评价肾功能损害的重要指标，而诊断病理性蛋白尿的金标准为24小时尿蛋白(24h Up)定量，但存在患者依从性差和膀胱不完全排空等问题，影响结果的准确性。研究报道，Up/Cr可以作为评价肾功能早期损害的指标，且准确度较高[3]。本研究主要探讨Up/Cr、Up及肾功能指标检测在慢性肾病诊断中的价值，现報道如下。, 百拇医药(陈吉虎)