摘要：随着分子生物学和免疫学的发展，源自中枢组织的P物质(SP)因其广泛分布于人体各个组织而成为研究的热点。SP主要通过与其特异性受体神经激肽1受体(NK-1)结合而具有多种生物学活性，比如诱导炎症环境，促进肿瘤细胞的神经向性，诱导肿瘤细胞的增殖、迁移及促进胰岛素抵抗，上述机制与子宫内膜癌的发病及预后关系密切，可作为临床诊治子宫内膜癌的一个新靶点。因此，本文就该因子的生物学功能、在肿瘤方面的作用及其与子宫内膜癌的关系进行综述。

    关键词：SP/NK-1R;肿瘤功能;子宫内膜癌

    Abstract：With the development of molecular biology and immunology， substance P(SP)derived from central tissues has become a research focus due to its widespread distribution in various human tissues.SP mainly has a variety of biological activities by binding to its specific receptor neurokinin 1 receptor(NK-1) ......