甲巯咪唑对初诊Graves病患者血清相关细胞因子 及microRNAs水平的影响(1)
摘要：目的 探討甲巯咪唑对初诊Graves'病患者血清相关细胞因子及microRNAs(miRNAs)水平的影响。方法 选取2016年12月～2019年1月于海阳市人民医院内分泌科就诊的36例Graves'病初诊患者为疾病组，给予甲巯咪唑治疗。另选取同期30例健康志愿者作为健康对照组。比较疾病组治疗前、治疗后及健康对照组甲状腺功能指标[游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、促甲状腺激素受体抗体(TRAb)]、细胞因子[IL-2、IL-6、IL-17、TGF-β1]、hs-CRP、microRNAs[miR-16、miR-142-3p、miR-146a、miR-155]的水平。结果 疾病组治疗前FT3、FT4，TRAb，IL-6、IL-17、TGF-β1、hs-CRP，miR-16、miR-142-3p、miR-155水平高于健康对照组，TSH、IL-2及miR-146a水平低于健康对照组，差异有统计学意义(P<0.05)。疾病组治疗后FT3、FT4、TRAb、IL-6、TGF-β1、hs-CRP、miR-16、miR-142-3p、miR-155水平低于治疗前，而TSH、IL-2、miR-146a水平高于治疗前，差异有统计学意义(P<0.05);IL-17水平治疗前后比较，差异无统计学意义(P>0.05)。疾病组治疗后TSH、IL-2、miR-146a水平低于健康对照组，IL-6、IL-17、TGF-β1、hs-CRP、miR-16、miR-155水平高于健康对照组，差异有统计学意义(P<0.05)，两组FT3、FT4、TRAb及miR-142-3p水平比较，差异无统计学意义表(P>0.05)。结论 甲巯咪唑可改善Graves'病患者的甲状腺功能，血清相关细胞因子及miRNAs可作为该病临床诊疗的辅助指标。
关键词：Graves'病;甲巯咪唑;细胞因子;microRNAs
中图分类号：R511.5 文献标识码：A DOI：10.3969/j.issn.1006-1959.2020.08.031
文章编号：1006-1959(2020)08-0101-04
Abstract：Objective To investigate the effect of methimazole on serum-related cytokines and microRNAs(miRNAs) in newly diagnosed Graves' disease patients.Methods From December 2016 to January 2019，36 newly diagnosed patients with Graves' disease who were treated in the Department of Endocrinology of Haiyang People's Hospital were selected as the disease group and treated with thiamazole.Another 30 healthy volunteers in the same period were selected as the healthy control group.Comparision of thyroid function indexes before treatment ，after treatment of disease group and healthy control group[free triiodothyronine(FT3)， free thyroxine(FT4)， thyroid stimulating hormone(TSH)，thyrotropin receptor antibody (TRAb)]，Cytokines [IL-2，IL-6，IL-17，TGF-β1]，hs-CRP，microRNAs[miR-16，miR-142-3p，miR-146a，miR-155].Results Before treatment，the levels of FT3，FT4，TRAb，IL-6，IL-17，TGF-β1，hs-CRP，miR-16，miR-142-3p，and miR-155 were higher than those of healthy controls，TSH，IL- 2 and miR-146a levels were lower than the healthy control group，the difference was statistically significant(P<0.05).After treatment，the levels of FT3，FT4TRAb，IL-6， TGF-β1，hs-CRP，miR-16，miR-142-3p，and miR-155 were lower than before treatment，the levels of TSH，IL-2 and miR-146a were higher than before treatment，the difference was statistically significant(P<0.05); the IL-17 level before and after treatment had no significant difference(P>0.05). After treatment，the levels of TSH，IL-2，miR-146a in the disease group were lower than those in the healthy control group，IL-6，IL-17，TGF-β1，hs-CRP， miR-16，miR-155 were higher than the healthy control group，the difference was statistically significant(P<0.05). There was no statistically significant difference in FT3，FT4，TRAb and miR-142-3p levels between the two groups(P>0.05). Conclusion Thiamazole can improve thyroid function in patients with Graves' disease.Serum-related cytokines and miRNAs can be used as auxiliary indicators for clinical diagnosis and treatment of this disease., http://www.100md.com(姜丽莉 王静 李振凤 周齐 栾雪静 任新雯)
关键词：Graves'病;甲巯咪唑;细胞因子;microRNAs
中图分类号：R511.5 文献标识码：A DOI：10.3969/j.issn.1006-1959.2020.08.031
文章编号：1006-1959(2020)08-0101-04
Abstract：Objective To investigate the effect of methimazole on serum-related cytokines and microRNAs(miRNAs) in newly diagnosed Graves' disease patients.Methods From December 2016 to January 2019，36 newly diagnosed patients with Graves' disease who were treated in the Department of Endocrinology of Haiyang People's Hospital were selected as the disease group and treated with thiamazole.Another 30 healthy volunteers in the same period were selected as the healthy control group.Comparision of thyroid function indexes before treatment ，after treatment of disease group and healthy control group[free triiodothyronine(FT3)， free thyroxine(FT4)， thyroid stimulating hormone(TSH)，thyrotropin receptor antibody (TRAb)]，Cytokines [IL-2，IL-6，IL-17，TGF-β1]，hs-CRP，microRNAs[miR-16，miR-142-3p，miR-146a，miR-155].Results Before treatment，the levels of FT3，FT4，TRAb，IL-6，IL-17，TGF-β1，hs-CRP，miR-16，miR-142-3p，and miR-155 were higher than those of healthy controls，TSH，IL- 2 and miR-146a levels were lower than the healthy control group，the difference was statistically significant(P<0.05).After treatment，the levels of FT3，FT4TRAb，IL-6， TGF-β1，hs-CRP，miR-16，miR-142-3p，and miR-155 were lower than before treatment，the levels of TSH，IL-2 and miR-146a were higher than before treatment，the difference was statistically significant(P<0.05); the IL-17 level before and after treatment had no significant difference(P>0.05). After treatment，the levels of TSH，IL-2，miR-146a in the disease group were lower than those in the healthy control group，IL-6，IL-17，TGF-β1，hs-CRP， miR-16，miR-155 were higher than the healthy control group，the difference was statistically significant(P<0.05). There was no statistically significant difference in FT3，FT4，TRAb and miR-142-3p levels between the two groups(P>0.05). Conclusion Thiamazole can improve thyroid function in patients with Graves' disease.Serum-related cytokines and miRNAs can be used as auxiliary indicators for clinical diagnosis and treatment of this disease., http://www.100md.com(姜丽莉 王静 李振凤 周齐 栾雪静 任新雯)