血糖和吸烟交互作用对男性颈动脉弹性的影响(1)
摘要：目的 评估糖尿病吸烟患者颈總动脉的弹性，探讨吸烟和血糖交互作用对颈动脉弹性与两因素单一作用的区别。方法 选择2018年3～12月甘肃省人民医院202例男性患者，分为糖尿病非吸烟组(T2DM组)、糖尿病吸烟组(SDM组)、正常对照组(NC组)，测定三组糖化血红蛋白、血脂、颈动脉内膜-中层厚度(IMT)、颈动脉弹性参数;比较三组一般资料、生化指标及颈动脉弹性指数，分析吸烟指数、糖化血红蛋白与颈动脉弹性的关系。结果 ①三组年龄、体重指数、腰/臀比、血压及血脂比较，差异无统计学意义(P>0.05);SDM组与T2DM 组糖化血红蛋白、空腹血糖比较，差异无统计学意义(P>0.05)。②SDM组IMT、僵硬度(β)、压力应变弹性系数(Eρ)、脉搏波传导速度(PWVβ)均高于T2DM组，顺应性(AC)低于T2DM组，差异有统计学意义(P<0.05);两组颈动脉增大指数(AI)比较，差异无统计学意义(P>0.05)。③SDM组中吸烟指数与颈动脉β、Ep、PWVβ均呈正相关(P<0.05)，与AC呈负相关(P<0.05)。④多元回归分析显示，糖化血红蛋白和吸烟指数是颈动脉β的独立相关因素，颈动脉β与两者均呈正相关(P<0.05)。结论 吸烟和血糖协同作用可加剧颈总动脉弹性功能减退，应采取积极的措施降低糖尿病患者的吸烟率。
关键词：2型糖尿病;吸烟;颈动脉弹性;血管回声跟踪
中图分类号：R543.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2020.13.021
文章编号：1006-1959(2020)13-0080-04
Effect of Blood Sugar and Smoking Interaction on Male Carotid Artery Elasticity
LI Ting-ting1，ZHU Ying1，WEI Li-qiong1，HUANG Jing2，HE Li1
(1.Early Childhood Development Center of Gansu Maternal and Child Health Hospital，Lanzhou 730000，Gansu，China;
2.Longdong University， Qingyang 745000，Gansu，China)
Abstract：Objective To evaluate the elasticity of the common carotid artery in diabetic smoking patients， and to explore the difference between the interaction of smoking and blood glucose on the carotid artery elasticity and the single effect of two factors.Methods 202 male patients from Gansu Provincial People's Hospital from March to December 2018 were divided into diabetic non-smoking group (T2DM group)， diabetic smoking group (SDM group)， and normal control group (NC group). Three groups of glycated hemoglobin， Blood lipids， carotid intima-media thickness (IMT)， carotid artery elasticity parameters; compare the three groups of general data， biochemical indicators and carotid artery elasticity index， and analyze the relationship between smoking index， glycated hemoglobin and carotid artery elasticity.Results ①There was no statistically significant difference in age， body mass index， waist/hip ratio， blood pressure and blood lipid among the three groups (P>0.05); there was no significant difference in glycated hemoglobin and fasting blood glucose between the SDM group and the T2DM group (P>0.05).②The IMT， stiffness (β)， pressure-strain elasticity coefficient (Eρ) and pulse wave conduction velocity (PWVβ) of the SDM group were higher than that of the T2DM group， and the compliance (AC) was lower than that of the T2DM group， the difference was statistically significant (P<0.05); Comparison of carotid artery enlargement index (AI) between the two groups was not statistically significant (P>0.05).③In the SDM group， smoking index was positively correlated with carotid β， Ep， PWVβ (P<0.05)， and negatively correlated with AC (P<0.05).④Multiple regression analysis showed that glycated hemoglobin and smoking index were independent related factors of carotid artery β， and carotid artery β was positively correlated with both (P<0.05).Conclusion The synergistic effect of smoking and blood sugar can aggravate the decrease of elasticity of the common carotid artery， and positive measures should be taken to reduce the smoking rate of diabetic patients., 百拇医药(李婷婷 朱瑛 魏丽琼 黄婧 何莉)
关键词：2型糖尿病;吸烟;颈动脉弹性;血管回声跟踪
中图分类号：R543.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2020.13.021
文章编号：1006-1959(2020)13-0080-04
Effect of Blood Sugar and Smoking Interaction on Male Carotid Artery Elasticity
LI Ting-ting1，ZHU Ying1，WEI Li-qiong1，HUANG Jing2，HE Li1
(1.Early Childhood Development Center of Gansu Maternal and Child Health Hospital，Lanzhou 730000，Gansu，China;
2.Longdong University， Qingyang 745000，Gansu，China)
Abstract：Objective To evaluate the elasticity of the common carotid artery in diabetic smoking patients， and to explore the difference between the interaction of smoking and blood glucose on the carotid artery elasticity and the single effect of two factors.Methods 202 male patients from Gansu Provincial People's Hospital from March to December 2018 were divided into diabetic non-smoking group (T2DM group)， diabetic smoking group (SDM group)， and normal control group (NC group). Three groups of glycated hemoglobin， Blood lipids， carotid intima-media thickness (IMT)， carotid artery elasticity parameters; compare the three groups of general data， biochemical indicators and carotid artery elasticity index， and analyze the relationship between smoking index， glycated hemoglobin and carotid artery elasticity.Results ①There was no statistically significant difference in age， body mass index， waist/hip ratio， blood pressure and blood lipid among the three groups (P>0.05); there was no significant difference in glycated hemoglobin and fasting blood glucose between the SDM group and the T2DM group (P>0.05).②The IMT， stiffness (β)， pressure-strain elasticity coefficient (Eρ) and pulse wave conduction velocity (PWVβ) of the SDM group were higher than that of the T2DM group， and the compliance (AC) was lower than that of the T2DM group， the difference was statistically significant (P<0.05); Comparison of carotid artery enlargement index (AI) between the two groups was not statistically significant (P>0.05).③In the SDM group， smoking index was positively correlated with carotid β， Ep， PWVβ (P<0.05)， and negatively correlated with AC (P<0.05).④Multiple regression analysis showed that glycated hemoglobin and smoking index were independent related factors of carotid artery β， and carotid artery β was positively correlated with both (P<0.05).Conclusion The synergistic effect of smoking and blood sugar can aggravate the decrease of elasticity of the common carotid artery， and positive measures should be taken to reduce the smoking rate of diabetic patients., 百拇医药(李婷婷 朱瑛 魏丽琼 黄婧 何莉)