中青年非重度冠脉狭窄患者血同型半胱氨酸水平与勃起功能的关系(1)
摘要：目的 探讨中青年非重度冠脉狭窄患者血清同型半胱氨酸水平与勃起功能的关系。方法 选取2018年9月～2019年9月在我院行冠脉造影且证实冠脉狭窄程度<75%的中青年患者96例，根据患者勃起功能障碍(ED)情况将其分为合并ED组(50例)及非合并ED组(46例)，比较两组血清Hcy水平，分析Hcy与勃起功能的关系。结果 合并ED组年龄大于非合并ED组，差异有统计学意义(P<0.05);合并ED组血清Hcy水平大于非合并ED组，差异有统计学意义(P<0.05);二元Logistic回归分析显示，年龄及血清Hcy水平为中青年非重度冠脉狭窄患者合并ED的危险因素;Spearman相关性分析显示，Hcy水平与IIEF-5评分呈负相关(r=-0.706，P<0.05)。结论 Hcy为合并ED的中青年非重度冠脉狭窄患者的危险因素，且合并ED的中青年非重度冠脉狭窄患者Hcy水平与勃起功能障碍的严重程度正相关。
关键词：非重度冠脉狭窄;血同型半胱氨酸;勃起功能障碍
中图分类号：R541.4 文獻标识码：A DOI：10.3969/j.issn.1006-1959.2020.15.034
文章编号：1006-1959(2020)15-0112-03
Abstract：Objective To investigate the relationship between serum homocysteine levels and erectile function in young and middle-aged patients with non-severe coronary stenosis.Methods A total of 96 young and middle-aged patients who underwent coronary angiography in our hospital from September 2018 to September 2019 and confirmed that the degree of coronary artery stenosis was less than 75% were selected. According to their erectile dysfunction (ED)， they were divided into the combined ED group (50 cases) and the noncombined ED group (46 cases)， compare the serum Hcy levels of the two groups of patients， and analyze the relationship between Hcy and erectile function.Results The age of the combined ED group was older than that of the non-combined ED group，the difference was statistically significant (P<0.05); the combined ED group had a higher serum Hcy level than the non-combined ED group，the difference was statistically significant (P<0.05); binary Logistic regression analysis showed，age and serum Hcy level are risk factors for middle-aged and young non-severe coronary stenosis patients with ED; Spearman correlation analysis showed that Hcy level was negatively correlated with IIEF-5 score (r=-0.706， P<0.05).Conclusion Hcy is a risk factor for young and middle-aged non-severe coronary stenosis patients with ED， and the level of Hcy is positively correlated with the severity of erectile dysfunction.
Key words：Non-severe coronary artery stenosis;Blood homocysteine;Erectile dysfunction
近年来随着我国经济发展，人民生活水平不断提高，冠心病的发病率逐年上升且发病年龄也趋于低龄化[1]，已经成为威胁我国人民生命健康安全的最重要疾病之一。勃起功能障碍(erectile dysfunction，ED)指阴茎不能达到和维持足够的勃起，无法满足满意的性生活，以致生活质量下降。已有研究证实[2]，冠脉狭窄和勃起功能障碍有着共同的发病机制和危险因素，而血管内皮功能紊乱是冠脉狭窄与勃起功能障碍共同的病理生理基础。血同型半胱氨酸(Hcy)为蛋氨酸和半胱氨酸代谢过程中产生的重要中间产物，正常情况下Hcy在体内被分解代谢，血中浓度较低。高水平的Hcy可引起血管内皮细胞损伤和调亡[3]，诱导血管平滑肌细胞增殖等，其在ED及冠脉狭窄的发生及发展中扮演着重要角色。非重度冠脉狭窄患者的年轻化，导致其对生活质量的要求越来越高，而勃起功能障碍也是亟需解决的问题。为此，本研究分析了解中青年非重度冠脉狭窄患者勃起功能障碍的影响因素，旨在为合并ED的中青年非重度冠脉狭窄病患者的诊疗提供参考，现报道如下。, 百拇医药(贺俊 张会清)
关键词：非重度冠脉狭窄;血同型半胱氨酸;勃起功能障碍
中图分类号：R541.4 文獻标识码：A DOI：10.3969/j.issn.1006-1959.2020.15.034
文章编号：1006-1959(2020)15-0112-03
Abstract：Objective To investigate the relationship between serum homocysteine levels and erectile function in young and middle-aged patients with non-severe coronary stenosis.Methods A total of 96 young and middle-aged patients who underwent coronary angiography in our hospital from September 2018 to September 2019 and confirmed that the degree of coronary artery stenosis was less than 75% were selected. According to their erectile dysfunction (ED)， they were divided into the combined ED group (50 cases) and the noncombined ED group (46 cases)， compare the serum Hcy levels of the two groups of patients， and analyze the relationship between Hcy and erectile function.Results The age of the combined ED group was older than that of the non-combined ED group，the difference was statistically significant (P<0.05); the combined ED group had a higher serum Hcy level than the non-combined ED group，the difference was statistically significant (P<0.05); binary Logistic regression analysis showed，age and serum Hcy level are risk factors for middle-aged and young non-severe coronary stenosis patients with ED; Spearman correlation analysis showed that Hcy level was negatively correlated with IIEF-5 score (r=-0.706， P<0.05).Conclusion Hcy is a risk factor for young and middle-aged non-severe coronary stenosis patients with ED， and the level of Hcy is positively correlated with the severity of erectile dysfunction.
Key words：Non-severe coronary artery stenosis;Blood homocysteine;Erectile dysfunction
近年来随着我国经济发展，人民生活水平不断提高，冠心病的发病率逐年上升且发病年龄也趋于低龄化[1]，已经成为威胁我国人民生命健康安全的最重要疾病之一。勃起功能障碍(erectile dysfunction，ED)指阴茎不能达到和维持足够的勃起，无法满足满意的性生活，以致生活质量下降。已有研究证实[2]，冠脉狭窄和勃起功能障碍有着共同的发病机制和危险因素，而血管内皮功能紊乱是冠脉狭窄与勃起功能障碍共同的病理生理基础。血同型半胱氨酸(Hcy)为蛋氨酸和半胱氨酸代谢过程中产生的重要中间产物，正常情况下Hcy在体内被分解代谢，血中浓度较低。高水平的Hcy可引起血管内皮细胞损伤和调亡[3]，诱导血管平滑肌细胞增殖等，其在ED及冠脉狭窄的发生及发展中扮演着重要角色。非重度冠脉狭窄患者的年轻化，导致其对生活质量的要求越来越高，而勃起功能障碍也是亟需解决的问题。为此，本研究分析了解中青年非重度冠脉狭窄患者勃起功能障碍的影响因素，旨在为合并ED的中青年非重度冠脉狭窄病患者的诊疗提供参考，现报道如下。, 百拇医药(贺俊 张会清)