数据挖掘技术在治疗艾滋病中药药理特征中的应用(1)
摘要：目的 运用数据挖掘技术研究治疗艾滋病中药的中药药理特征。方法 在治疗艾滋病中药数据库中共有中药463味，其中，治疗艾滋病中药183味，非治疗艾滋病中药280味，以“是否是治療艾滋病中药”为目标字段，以144项中药药理作用作为输入字段，运用非参数统计、交叉表和卡方检验等统计方法，比较两者在中药药理方面的差异。结果 ①共筛选280味非治疗艾滋病中药，183味治疗艾滋病的中药。②非参数检验显示，治疗艾滋病的中药在以下药理作用方面的比例高于非治疗艾滋病的中药，具体包括发汗、解热、镇痛、抗病毒、抗过敏、增强免疫功能、促进消化液分泌等等，差异有统计学意义(P<0.05);治疗艾滋病的中药在在泻下和止血方面的比例低于非治疗艾滋病的中药，差异有统计学意义(P<0.05)。③描述性？字2检验显示，治疗艾滋病中药具有发汗、解热、镇痛、抗病毒、抗过敏、增强免疫功能、促进消化液分泌、利尿、保肝、降血脂、降血糖、强心、扩张血管、兴奋交感神经、助消化、抗血小板凝集、抗凝血、增加冠脉流量、抗心肌缺血、升高白细胞、增强单核吞噬细胞吞噬功能、增强下丘脑-垂体-性腺轴功能、止呕及抗衰老的药理作用者的比例高于非艾滋病中药具有相应药理作用者，差异有统计学意义(P<0.05);治疗艾滋病中药具有泻下、止血药理作用者的比例低于非艾滋病中药具有相应药理作用者，差异有统计学意义(P<0.05)。结论 治疗艾滋病中药多具有发汗、解热、镇痛、抗病毒、抗过敏、增强免疫功能、促进消化液分泌、利尿、保肝、降血脂、降血糖、强心、扩张血管、兴奋交感神经、助消化、抗血小板凝集、抗凝血、增加冠脉流量、抗心肌缺血、升高白细胞、增强单核吞噬细胞吞噬功能、增强下丘脑-垂体-性腺轴、止呕、抗衰老等药理作用，而泻下和止血作用较少。另外，本研究初步说明中药具有多层次、多途径、多靶点治疗艾滋病的作用，与西药哈特疗法只有抗病毒一个作用靶点大相径庭。
关键词：数据挖掘;艾滋病;中药;中药药理
Abstract：Objective To use data mining technology to study the pharmacological characteristics of traditional Chinese medicine for the treatment of AIDS.Methods There were a total of 463 Chinese medicines in the database of Chinese medicines for treating AIDS. Among them， there are 183 Chinese medicines for treating AIDS and 280 Chinese medicines for non-AIDS. With "Was it a Chinese medicine for treating AIDS" as the target field， 144 Chinese medicine pharmacological effects were used as input fields. Statistical methods such as non-parametric statistics， cross-tabulation and chi-square test are used to compare the differences in the pharmacology of Chinese medicine.Results ①A total of 280 Chinese medicines for non-AIDS treatment and 183 Chinese medicines for treatment of AIDS were screened. ②Non-parametric tests show that the proportion of traditional Chinese medicines for AIDS treatment was higher than that of non-AIDS medicines in terms of the following pharmacological effects， including sweating， antipyretic， analgesic， antiviral， anti-allergic， enhancing immune function， promoting digestive juice secretion， etc，the difference was statistically significant (P<0.05); the ratio of diarrhea and hemostasis in AIDS treatment was lower than that of non-AIDS treatment，the difference was statistically significant (P<0.05). ③The descriptive χ2 test showed that Chinese medicine for the treatment of AIDS has sweating， antipyretic， analgesic， antiviral， antiallergic， immune function enhancement， digestive juice secretion， diuresis， liver protection， lowering blood lipid， lowering blood sugar， strengthening the heart， and dilating blood vessels，excites sympathetic nerves， aids digestion， anti-platelet aggregation， anti-coagulation， increases coronary flow， anti-myocardial ischemia， increases white blood cells， enhances the phagocytic function of mononuclear phagocytes， enhances the function of the hypothalamic-pituitary-gonadal axis， anti-vomiting The proportion of people with anti-aging pharmacological effects was higher than that of non-AIDS Chinese medicines with corresponding pharmacological effects，the difference was statistically significant (P<0.05); the proportion of people with AIDS treatments with diarrhea and hemostatic pharmacological effects was lower than that of non-AIDS Chinese medicines. For those with corresponding pharmacological effects， the difference was statistically significant (P<0.05).Conclusion Traditional Chinese medicine for the treatment of AIDS has the advantages of sweating， antipyretic， analgesic， antiviral， anti-allergic， enhancing immune function， promoting digestive juice secretion， diuresis， protecting liver， lowering blood lipid， lowering blood sugar， strengthening heart， expanding blood vessels， exciting sympathetic nerves，aid digestion， anti-platelet aggregation， anti-coagulation， increase coronary flow， anti-myocardial ischemia， increase white blood cells， enhance phagocytic function of mononuclear phagocytes， enhance hypothalamic-pituitary-gonad axis， anti-vomiting， anti-aging and other pharmacological effects，and less diarrhea and hemostasis. In addition， this study preliminarily showed that traditional Chinese medicine has a multi-level， multi-channel， and multi-target treatment of AIDS， which was quite different from the Western medicine Hart therapy which has only one target of antiviral action., 百拇医药(蔡妙焕 赖昌生)
关键词：数据挖掘;艾滋病;中药;中药药理
Abstract：Objective To use data mining technology to study the pharmacological characteristics of traditional Chinese medicine for the treatment of AIDS.Methods There were a total of 463 Chinese medicines in the database of Chinese medicines for treating AIDS. Among them， there are 183 Chinese medicines for treating AIDS and 280 Chinese medicines for non-AIDS. With "Was it a Chinese medicine for treating AIDS" as the target field， 144 Chinese medicine pharmacological effects were used as input fields. Statistical methods such as non-parametric statistics， cross-tabulation and chi-square test are used to compare the differences in the pharmacology of Chinese medicine.Results ①A total of 280 Chinese medicines for non-AIDS treatment and 183 Chinese medicines for treatment of AIDS were screened. ②Non-parametric tests show that the proportion of traditional Chinese medicines for AIDS treatment was higher than that of non-AIDS medicines in terms of the following pharmacological effects， including sweating， antipyretic， analgesic， antiviral， anti-allergic， enhancing immune function， promoting digestive juice secretion， etc，the difference was statistically significant (P<0.05); the ratio of diarrhea and hemostasis in AIDS treatment was lower than that of non-AIDS treatment，the difference was statistically significant (P<0.05). ③The descriptive χ2 test showed that Chinese medicine for the treatment of AIDS has sweating， antipyretic， analgesic， antiviral， antiallergic， immune function enhancement， digestive juice secretion， diuresis， liver protection， lowering blood lipid， lowering blood sugar， strengthening the heart， and dilating blood vessels，excites sympathetic nerves， aids digestion， anti-platelet aggregation， anti-coagulation， increases coronary flow， anti-myocardial ischemia， increases white blood cells， enhances the phagocytic function of mononuclear phagocytes， enhances the function of the hypothalamic-pituitary-gonadal axis， anti-vomiting The proportion of people with anti-aging pharmacological effects was higher than that of non-AIDS Chinese medicines with corresponding pharmacological effects，the difference was statistically significant (P<0.05); the proportion of people with AIDS treatments with diarrhea and hemostatic pharmacological effects was lower than that of non-AIDS Chinese medicines. For those with corresponding pharmacological effects， the difference was statistically significant (P<0.05).Conclusion Traditional Chinese medicine for the treatment of AIDS has the advantages of sweating， antipyretic， analgesic， antiviral， anti-allergic， enhancing immune function， promoting digestive juice secretion， diuresis， protecting liver， lowering blood lipid， lowering blood sugar， strengthening heart， expanding blood vessels， exciting sympathetic nerves，aid digestion， anti-platelet aggregation， anti-coagulation， increase coronary flow， anti-myocardial ischemia， increase white blood cells， enhance phagocytic function of mononuclear phagocytes， enhance hypothalamic-pituitary-gonad axis， anti-vomiting， anti-aging and other pharmacological effects，and less diarrhea and hemostasis. In addition， this study preliminarily showed that traditional Chinese medicine has a multi-level， multi-channel， and multi-target treatment of AIDS， which was quite different from the Western medicine Hart therapy which has only one target of antiviral action., 百拇医药(蔡妙焕 赖昌生)