甘草酸干预炎症信号通路新进展(3)
5總结与展望
GA不仅可以对NF-κB、MAPK、TLRs、PI3K/AKT/TOR等信号通路发挥很好的干预作用，减少NF-κB、IL-6β、IL-6α、IL-10、HGMB1等炎症因子的释放来发挥对机体的保护作用，还可以对其它炎症信号通路如JAK/STAT、Notch、Wnt、PKC均有不同程度的干预，进而减少炎症因子IL-6β、IL-6α、IL-10、HGMB1等的释放与减轻炎症反应对机体的刺激，对机体进行保护[18-24]。随着社会、环境、心理、药物等诸多因素对机体的影响，慢性炎症产生的影响也更加突出，慢性疾病越来越普遍。由于炎症因子介入了疾病发生发展的过程，而GA可以通过干预多个炎症信号通路来减少或抑制炎症因子的释放，这对各种慢性疾病的临床治疗将会有很广阔的临床应用前景。
参考文献：
[1]Hayden MS，Ghosh S.Shared principles in NF-kappaB signaling[J].Cell，2008，132(3)：344-62.
, 百拇医药
[2]Natoli G.Specialized chromatin patterns in the control of inflammatory gene expression[J].Curr Top Microbiol Immunol，2011，349：61-72.
[3]Barnes PJ，Larin M.Mechanisms of disease–nuclear factor-kappa-B：a pivotal transcription factor in chronic inflammatory diseases(Review)[J].N Engl J Med，1997，336(15)：1066-71.
[4]Bierhaus A，Schiekofer S，Schwaninger M，et al.Diabetes-associated sustained activation of the transcription factor nuclear factor kappaB[J].Diabetes，2001，50(12)：2792–2808.
, 百拇医药
[5]Lawrence T，Gilroy DW，Colville-Nash PR，et al.Possible new role for NF-kappaB in the resolution of inflammation[J].Nat Med，2001，7(12)：1291-7.
[6]Dai JH，Iwatani Y，Ishida T，et al.Glycyrrhizin enhances interleukin-12 production in peritoneal macrophages[J].Immunology，2001，103(2)：235-43.
[7]Feng L，Zhu MM，Zhang MH，et al.Protection of glycyrrhizic acid against AGEs-induced endothelial dysfunction through inhibiting RAGE/NF-κB pathway activation in human umbilical vein endothelial cells[J].J Ethnopharmacol，2013，148(1)：27-36.
, http://www.100md.com
[8]English JM，Cobb MH.Pharmacological inhibitors of MAPK pathways[J].Trends Pharmacol Sci，2002，23(1)：40-5.
[9]Gong G，Xiang L，Yuan L，et al.Protective effect of glycyrrhizin，a direct HMGB1 inhibitor，on focal cerebral ischemia/reperfusion-induced inflammation，oxidative stress，and apoptosis in rats[J].PLoS One，2014，9(3)：e89450.
[10]Zhao H，Liu Z，Shen H，et al.Glycyrrhizic acid pretreatment prevents sepsis-induced acute kidney injury via suppressing inflammation，apoptosis and oxidative stress[J].Eur J Pharmacol，2016，781：92-9.
, http://www.100md.com
[11]Zhao H，Zhao M，Wang Y，et al.Glycyrrhizic Acid Prevents Sepsis-Induced Acute Lung Injury and Mortality in Rats[J].J Histochem Cytochem，2016，64(2)：125-37.
[12]Wu CX，He LX，Guo H，et al.Inhibition effect of glycyrrhizin in lipopolysaccharide-induced high-mobility group box 1 releasing and expression from RAW264.7 cells[J].Shock，2015，43(4)：412-21.
[13]Hennessy EJ，Parker AE，O’Neill LA.Targeting Toll-like receptors：emerging therapeutics？[J].Nat Rev Drug Discov，2010，9(4)：293-307., http://www.100md.com(安春耀 李昌玲 刘德山)
GA不仅可以对NF-κB、MAPK、TLRs、PI3K/AKT/TOR等信号通路发挥很好的干预作用，减少NF-κB、IL-6β、IL-6α、IL-10、HGMB1等炎症因子的释放来发挥对机体的保护作用，还可以对其它炎症信号通路如JAK/STAT、Notch、Wnt、PKC均有不同程度的干预，进而减少炎症因子IL-6β、IL-6α、IL-10、HGMB1等的释放与减轻炎症反应对机体的刺激，对机体进行保护[18-24]。随着社会、环境、心理、药物等诸多因素对机体的影响，慢性炎症产生的影响也更加突出，慢性疾病越来越普遍。由于炎症因子介入了疾病发生发展的过程，而GA可以通过干预多个炎症信号通路来减少或抑制炎症因子的释放，这对各种慢性疾病的临床治疗将会有很广阔的临床应用前景。
参考文献：
[1]Hayden MS，Ghosh S.Shared principles in NF-kappaB signaling[J].Cell，2008，132(3)：344-62.
, 百拇医药
[2]Natoli G.Specialized chromatin patterns in the control of inflammatory gene expression[J].Curr Top Microbiol Immunol，2011，349：61-72.
[3]Barnes PJ，Larin M.Mechanisms of disease–nuclear factor-kappa-B：a pivotal transcription factor in chronic inflammatory diseases(Review)[J].N Engl J Med，1997，336(15)：1066-71.
[4]Bierhaus A，Schiekofer S，Schwaninger M，et al.Diabetes-associated sustained activation of the transcription factor nuclear factor kappaB[J].Diabetes，2001，50(12)：2792–2808.
, 百拇医药
[5]Lawrence T，Gilroy DW，Colville-Nash PR，et al.Possible new role for NF-kappaB in the resolution of inflammation[J].Nat Med，2001，7(12)：1291-7.
[6]Dai JH，Iwatani Y，Ishida T，et al.Glycyrrhizin enhances interleukin-12 production in peritoneal macrophages[J].Immunology，2001，103(2)：235-43.
[7]Feng L，Zhu MM，Zhang MH，et al.Protection of glycyrrhizic acid against AGEs-induced endothelial dysfunction through inhibiting RAGE/NF-κB pathway activation in human umbilical vein endothelial cells[J].J Ethnopharmacol，2013，148(1)：27-36.
, http://www.100md.com
[8]English JM，Cobb MH.Pharmacological inhibitors of MAPK pathways[J].Trends Pharmacol Sci，2002，23(1)：40-5.
[9]Gong G，Xiang L，Yuan L，et al.Protective effect of glycyrrhizin，a direct HMGB1 inhibitor，on focal cerebral ischemia/reperfusion-induced inflammation，oxidative stress，and apoptosis in rats[J].PLoS One，2014，9(3)：e89450.
[10]Zhao H，Liu Z，Shen H，et al.Glycyrrhizic acid pretreatment prevents sepsis-induced acute kidney injury via suppressing inflammation，apoptosis and oxidative stress[J].Eur J Pharmacol，2016，781：92-9.
, http://www.100md.com
[11]Zhao H，Zhao M，Wang Y，et al.Glycyrrhizic Acid Prevents Sepsis-Induced Acute Lung Injury and Mortality in Rats[J].J Histochem Cytochem，2016，64(2)：125-37.
[12]Wu CX，He LX，Guo H，et al.Inhibition effect of glycyrrhizin in lipopolysaccharide-induced high-mobility group box 1 releasing and expression from RAW264.7 cells[J].Shock，2015，43(4)：412-21.
[13]Hennessy EJ，Parker AE，O’Neill LA.Targeting Toll-like receptors：emerging therapeutics？[J].Nat Rev Drug Discov，2010，9(4)：293-307., http://www.100md.com(安春耀 李昌玲 刘德山)
参见：首页 > 中医药 > 中药专业 > 中草药汇编 > 中药大典 > 根类 > 甘草