谢宏霞 范雪静 胡晓洁 王兴臣

    摘要：脑小血管病认知障碍是血管性痴呆中最常见的一种类型，高浓度的的同型半胱氨酸是认知功能出现障碍的独立危险因素。西医多采用胆碱酯酶抑制剂联合甲钴胺片的基础上补充维生素B及叶酸的方式对脑小血管病认知障碍伴高同型半胱氨酸血症进行医治，但疗效有限，且有一定的毒副作用。基于国医大师王新陆教授团队提出的血浊理论将其病因病机归于血浊所致的气血失调、脑神失养，为脑小血管病认知障碍伴高同型半胱氨酸血症的中医防治提供新思路，进一步充实血浊理论的临床治疗内容。

    关键词：血浊；同型半胱氨酸；脑小血管病；认知功能障碍

    中图分类号：R743 文献标志码：A 文章编号：1007-2349(2023)03-0013-04

    Discussion on the Early Treatment of Cerebral Small Vascular Disease with Cognitive Dysfunction Associated with Hyperhomocysteinemia Based on the Theory of Blood Turbidity

    XIE Hong-xi¹， FAN Xue-jing¹， HU Xiao-jie²， WANG Xing-chen²

    (1. Shandong University of Traditional Chinese Medicine， Jinan 250013， China;

    2. The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine， Jinan 250001， China)

    【Abstract】The cognitive dysfunction of cerebral small vascular disease is the most common type of vascular dementia. High concentration of homocysteine is an independent risk factor for the occurrence of cognitive dysfunction. Western medicine usually uses cholinesterase inhibitor combined with mecobalamine tablets to supplement vitamin B and folic acid on the basis of the treatment of the cognitive dysfunction of cerebral small vascular disease with hyperhomocysteinemia ......