健脾补肾法对人结直肠癌移植瘤组织TLR4、RAGE、NF-κB及CD34、D2-40的影响
王梦涵 姚欣 袁婉婧 李梅 黄兴瑜 孙怡 曾宏亮 谢彪![](/images/paper/1007-2349/202303/20-1-l.jpg)
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摘要:目的 探討健脾补肾法对人结直肠癌移植瘤组织TLR4、RAGE、NF-κB及CD34、D2-40的影响。方法 于裸鼠右腿内侧接种人结肠癌细胞,建立人结肠癌裸鼠皮下移植瘤模型,15d后脱颈处死剥离瘤体。对照组用生理盐水灌胃,实验组用健脾补肾中药灌胃,免疫组化法检测2组移植瘤组织中TLR4、RAGE、NF-κB及CD34、D2-40的表达。结果 免疫组化显示,与对照组相比,实验组的移植瘤组织中TLR4、RAGE、NF-κB的表达均明显下调(P1, YAO Xin1, YUAN Wan-jing2, LI Mei2, HUANG Xing-yu2, SUN Yi1, ZENG Hong-liang3, XIE Biao2
(1. Hunan University of Traditional Chinese Medicine, Changsha 410208, China; 2. The Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410005, China; 3. Hunan Institute of Traditional Chinese Medicine, Changsha 410031, China)
【Abstract】To study the effect of spleen-and-kidney invigorating method on TLR4 ......
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