As proteins from different evolutionary originsmay have similar structure， threading methods aredesigned to match the query sequence directly ontothe 3-D structures of other solved proteins， with thegoal of recognizing folds similar to the query evenwhen there is no evolutionary relationship betweenthe query and the template proteinuo. Structural datacan be used to detect proteins with similar functionwhose sequences have diverged beyond a level sim-ilarity that can reliably detected using sequencecomparison methods[1]. Therefore ......