【摘要】 目的研究氟西汀对卒中后抑郁与经典用药的疗效比较。方法将60例脑卒中后抑郁患者随机分为研究组30例和对照组30例, 在脑卒中常规治疗及心理治疗的基础上, 研究组联合氟西汀治疗, 对照组联合阿米替林治疗, 观察4w。治疗前和治疗末采用汉密顿抑郁量表评定临床疗效。结果研究组总有效率82.0%, 对照组72.0%, 两组比较差异有显著性(p<0.05)。结论氟西汀治疗脑卒中后抑郁临床疗优于经典用药，且副作用更小，依从性更好。

    【关键词】 脑卒中; 抑郁; 氟西汀; 阿米替林; 疗效比较

    Compare the effect of fluoxetine to treat posr-stroke depression

    Du Xiao-Li

    【Abstract】 Objective: To compare effect of fluoxetine with amitriptyline to treat posr-stroke depression (PSD). Methods: Divided 60 patients suffered PSD into study group and controlled group randomly. Each group with 30 patients based on conventional therapy and psychotherapy, study group used fluoxetine and controlled group used amitriptyline. Observe 4 weeks. Measure the effect with HAMA scores before and after treatment. Results: The total effective rate of study group was 82.0%,controlled group was 72.0%, there was definite difference between these two groups. Conclusion: The effect of fluoxetine to treat PSD is better than amitriptyline with less side effect, better compliance. ......