艾迪注射液联合MF/CF方案化疗晚期胃癌临床观察(1)
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【摘要】目的:观察艾迪注射液联合MF/CF方案治疗晚期胃癌的疗效及其不良反应。方法:将晚期胃癌患者50例随机分成两组,治疗组25例,采用艾迪注射液联合MF/CF方案治疗,对照组25例,单用MF/CF方案化疗。四周为1个周期,2个周期后判定疗效,记录不良反应。结果:治疗组25例完全缓解(CR)3例,部分缓解(PR)14例,有效(CR+PR)17例,总有效率68%。对照组25例CR2例(8%),PR13例(52%),有效15例(60%)。两组比较无显著统计学意义(P>0.05),不良反应治疗组恶心、呕吐、脱发、口腔溃疡、白细胞、血红蛋白及血小板减少较对照组明显减轻(P<0.05)。结论:艾迪注射液联合MF/CF方案较单纯应用MF/CF方案治疗晚期胃癌疗效相当,但前者能降低化疗不良反应发生率,提高患者生活质量。
【关键词】艾迪注射液;胃癌;MF/CF方案;化疗
【中图分类号】R735.2【文献标识码】A【文章编号】1007-8517(2010)10-031-2
CLINICAL EFFICACY OF AIDI INJECTION COMBINED WITH MF/CF IN THE TREATMENT OF ADVANCED GASTRIC CARCINOMA
【Abstract】Objective:To investigate the therapy efficacy and adverse reactions of the Aidi injection combined with MC/CF to treat advaced gastric carcinoma. Methods:Twenty-five cases of advanced gastric cancer patients were randomly divided in two groups. Treatment group (25 patients)were treated by combining Aidi and MC/CF,Control group(25 patients)were treated by only MC/CF. Both groups received two cycles with four weeks as a cycle. Results:Among 50 cases with advanced gastric carcinoma,3 cases reached compete response,14 cases partial response,The overall response rate was 68% in treatment group,while 2 cases reached compete response(8%),13 cases partial response(52%),The overall response rate was 60% in treatment group, with no significant difference between the two groups(P>0.05).The incidence of the nausea,vomiting,interleukin decline of the treatment group was better than control group(P<0.05). Conclusion:Both Aidi injection with MC/CF and the MC/CF alone in the treatment of advanced gastric carcinoma have similar therapy efficacy objectively,but the former can reduce adverse reactions and improve the quality of life.
【Key words】Aidi injection;Gastric carcinoma;MF/CF;chemotherapy
胃癌是我国最常见的恶性肿瘤,占总恶性肿瘤死亡人数的23%。早期症状不典型,故确诊时多数已进入晚期,失去手术机会,化疗成为晚期胃癌患者治疗的主要方法,我院自2008年1月至2009年12月采用艾迪注射液联合MF/CF方案治疗晚期胃癌,取得了较好的化疗疗效,现报告如下。
1资料与方法
1.1一般资料收集2008年1月至2009年12月我院肿瘤科住院的晚期胃癌病例50例,全部经胃镜、CT、病理组织学或者细胞学CEA确诊,且均为晚期不能手术的胃癌患者。其中男性28例,女性22例。随机分为两组,治疗组和对照组各25例,生活能自理,无严重心脏病及糖尿病史,无精神神经疾病,无消化道梗阻、营养吸收障碍和严重并发症,化疗前患者血常规(尤其是白细胞、血小板、血红蛋白)、肝肾功能、心电图及心功能无异常,所有患者无明显化疗禁忌症,两组一般资料及病情程度差异比较无统计学意义(P>0 ......
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