【摘要】目的:探讨结肠康Ⅰ号对溃疡性结肠炎的修复作用及对血清IL-6、IL-10的影响。方法:SD大鼠60只，随机分为4组，分别为正常对照组、模型组、结肠康I号大、小剂量组。以5%2、4、6，三硝基苯磺酸(TNBs)诱导大鼠形成结肠炎症，实验完成后处死大鼠，观察大体形态学及组织病理学改变，并采用放射免疫法检测各组大鼠的血清IL-6、IL-10的水平。结果:结肠康Ⅰ号能有效提高大鼠血清IL-10含量，降低IL-6含量，并对损伤的大肠黏膜有明显的修复作用。结论:结肠康Ⅰ号对大鼠实验性溃疡性结肠炎疗效显著，其作用机制可能与调节机体的免疫有关。

    【关键词】结肠康I号;溃疡性结肠炎;IL-6;IL-10

    【中图分类号】R-33【文献标识码】A【文章编号】1007-8517(2010)14-086-2

    Abstract:Objective:To investigate the repair on ulcerative colitis and affect on serum IL-6，IL-10 of Jiechangkang No1. Methods:60 SD rats were randomly divided into 4 groups: normal control group，model group，Jiechangkang No1 large dose group and small dose group.With 5% 2，4，6，-trinitrobenzene sulfonic acid(TNBs)induced the formation of colonic inflammation，rats were sacrificed to observe the general morphology and histopathological changes，and detected by radioimmunoassay rats serum IL-6 ......