Th17细胞及Treg细胞在喉癌外周血中的表达(1)
【摘要】目的:检测喉鳞状细胞癌患者外周血Treg细胞和Thl7细胞比例,研究其变化与意义。方法:采用流式细胞技术检测10例健康对照者和42例喉鳞状细胞癌患者外周血Treg和Thl7细胞比例,并观察Th17/Treg在喉癌分期中的变化。结果:与健康对照组比较,喉癌患者外周血Treg细胞和Th17细胞比例明显升高(P<0.05);发生淋巴结转移者较无淋巴结转移者的Treg和Th17细胞比例增高(P<0.05);通过分析不同喉癌分期中Th17/Treg细胞的分布,结果发现Ⅲ+Ⅳ期组Th17细胞的比例和Ⅰ+Ⅱ期无明显差异,而Treg细胞在Ⅲ+Ⅳ期比Ⅰ+Ⅱ期明显增高(P<0.05)。结论:喉癌外周血中Th17和Treg细胞数量增多,二者比例增高,并随着疾病的进展而增加,表明二者均参与了喉癌的发生发展过程。
【关键词】喉鳞状细胞癌;Thl7细胞;Treg细胞;表达
【中图分类号】R730.6 【文献标志码】 A 【文章编号】1007-8517(2016)08-0086-02
Abstract:Objective To investigate Th17 /T regulatory ( Treg) cell ratio in laryngeal cancer.Methods The two T cell subsets were determined in the peripheral blood of 42 patients with laryngeal squamous cell carcinoma( LSCC) and 10 healthy volunteers by flow cytometry.Results Compared with the healthy controls ......
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【关键词】喉鳞状细胞癌;Thl7细胞;Treg细胞;表达
【中图分类号】R730.6 【文献标志码】 A 【文章编号】1007-8517(2016)08-0086-02
Abstract:Objective To investigate Th17 /T regulatory ( Treg) cell ratio in laryngeal cancer.Methods The two T cell subsets were determined in the peripheral blood of 42 patients with laryngeal squamous cell carcinoma( LSCC) and 10 healthy volunteers by flow cytometry.Results Compared with the healthy controls ......
您现在查看是摘要页,全文长 3701 字符。