正交试验优化氯霉素包合工艺的实验研究(1)
【摘 要】 目的：研究复方炉甘石氯霉素包合的制备工艺，以提高氯霉素洗剂的稳定性。方法：采用饱和水溶液法制备氯霉素包合物，通过正交试验，以包封率为考察指标，筛选最佳工艺条件。结果：氯霉素-γ-环糊精包合物的最佳制备工艺条件为：氯霉素与γ-CD的质量比为1∶2，包合温度为40℃，包合时间为2h，γ-CD与水的用量比例为1∶30(g/ml)。用该工艺获得的氯霉素包合物进行制备复方炉甘石氯霉素洗剂，在6个月后检测结果与生产时进行对比，氯霉素含量较为稳定。结论：γ-环糊精包合氯霉素制备的复方炉甘石氯霉素洗剂工艺稳定，重现性良好，为工业化生产复方炉甘石氯霉素洗剂提供实验依据。
【关键词】 复方炉甘石氯霉素；工艺改进；正交实验
【中图分类号】R283.6 【文献标志码】 A 【文章编号】1007-8517(2016)12-0022-02
Abstract：Objective To study the Improvement process of the lotion of compound of calamine chloramphenicol. Methods Using a saturated aqueous solution inclusion complex of chloramphenicol prepared by orthogonal experiment to evaluate the preparation of entrapment was screened optimum conditions. Results Chloramphenicol was preferably after γ-cyclodextrin optimum preparation conditions cyclodextrin inclusion complexes as follows： the mass ratio of chloramphenicol and γ-CD was 1∶2 ......
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【关键词】 复方炉甘石氯霉素；工艺改进；正交实验
【中图分类号】R283.6 【文献标志码】 A 【文章编号】1007-8517(2016)12-0022-02
Abstract：Objective To study the Improvement process of the lotion of compound of calamine chloramphenicol. Methods Using a saturated aqueous solution inclusion complex of chloramphenicol prepared by orthogonal experiment to evaluate the preparation of entrapment was screened optimum conditions. Results Chloramphenicol was preferably after γ-cyclodextrin optimum preparation conditions cyclodextrin inclusion complexes as follows： the mass ratio of chloramphenicol and γ-CD was 1∶2 ......
您现在查看是摘要页，全文长 3611 字符。