半夏泻心汤联合三联疗法治疗幽门螺旋杆菌相关性胃炎的Meta分析(1)
【摘 要】 目的：系统评价半夏泻心汤联合三联疗法治疗幽门螺旋杆菌相关性胃炎(HAG) 的有效性及安全性。方法：计算机检索CNKI、VIp、WanFang、CBM、pubMed数据库，纳入相关的随机对照研究(RCT)，检索时间期限为建库至2020年1月15日，运用EndNoteX7软件对检索所得的重复文献进行剔除，严格根据纳入和排除标准确定最终纳入文献，对纳入文献进行方法学质量评价，运用Revman5.3软件进行Meta分析。结果：最终纳入16篇文献。Meta分析结果显示：半夏泻心汤联合三联疗法治疗HAG总有效率[RR=1.25，95%CI(1.19，1.31)，P<0.05]、Hp转阴率[RR=1.26，95%CI(1.18，1.35)，P<0.05]优于对照组，且不良反应率[RR=0.41，95%CI(0.23，0.73)，P<0.05]小于对照组，差异均具有统计学意义。结论：相比于单用西药，半夏泻心汤联合三联疗法治疗HAG疗效更好，且更安全。但由于本次研究納入的文献数量较少且质量不高，所得结果还需更多、更高质量的RCT进行验证。
【关键词】 半夏泻心汤;三联疗法;幽门螺旋杆菌相关性胃炎;Meta分析
【中图分类号】R256.3 【文献标志码】 A【文章编号】1007-8517(2020)24-0075-05
Abstract：Objective To systematically review of the efficacy and safety of Banxia Xiexin Decoction combined with triple therapy in the treatment of Helicobacter pylori-associated gastritis.Methods CNKI、VIp、WanFang、CBM、pubMed were searched online to collect randomized controlled trials(RCTs) of Banxia Xiexin Decoction combined with triple therapy for Helicobacter pylori-associated gastritis from inception to January 15， 2020.Eliminate duplicate documents retrieved with EndNoteX7 software.Finalize the included documents strictly according to the inclusion and exclusion criteria， and evaluate the methodologicalquality of the included documents.Meta Analysis with Revman5.3 Software.Resluts Finally included 16 articles.The meta-analysis results show that the total effective rate of Banxia Xiexin Decoction combined with triple therapy in the treatment of HAG [RR=1.25，95%CI (1.19，1.31)，P<0.05]， Hp negative rate [RR=1.26， 95%CI(1.18，1.35)， P<0.05]is better than the control group， and the adverse reaction rate [RR=0.41，95%CI(0.23，0.73)，P<0.05]is smaller than the control group， the differences are statistically significant.Conclusion Compared with western medicine alone， Banxia Xiexin Decoction combined with triple therapy is more effective and safer in treating HAG. However， due to the small number and low quality of the literature included in this study， more and higher quality RCTs are needed to verify the results.
Keywords：Banxia Xiexin Decoction，Triple Therapy，Helicobacter pylori-associated Gastritis，Meta Analysis
幽门螺旋杆菌(Helicobacter pylori，Hp)是一种主要分布于胃黏膜组织中的螺旋形微厌氧菌，感染后能引起慢性炎症[1]。HAG是指Hp感染后引起胃及十二指肠发生炎性变化，从而出现消化道症状。Hp感染是胃炎、胃溃疡、十二指肠溃疡等胃肠疾病的重要病因，并与胃癌的发生关系密切，对人类健康造成严重危害，所以根除Hp对于防治胃肠疾病尤为重要。幽门螺杆菌感染后患者多表现为胃脘部疼痛、胀闷不舒、嗳气、反酸、恶心呕吐、食欲减退等症状。中医从整体观念出发，遵从辨证论治原则，结合临床症状，通常将其归属于胃脘痛、痞满、嘈杂、反酸等病范畴。目前有不少临床研究证实半夏泻心汤联合三联疗法治疗HAG相比于单用西药疗效更好，且安全可靠。本研究收集半夏泻心汤联合三联疗法治疗HAG的RCT，依据循证医学的方法学原理，对其进行Meta分析，系统的探究并评估其治疗HAG的有效性及安全性，以期为临床实践提供参考依据。, 百拇医药(许文娟 彭瑶 刘富林 夏旭婷)
【关键词】 半夏泻心汤;三联疗法;幽门螺旋杆菌相关性胃炎;Meta分析
【中图分类号】R256.3 【文献标志码】 A【文章编号】1007-8517(2020)24-0075-05
Abstract：Objective To systematically review of the efficacy and safety of Banxia Xiexin Decoction combined with triple therapy in the treatment of Helicobacter pylori-associated gastritis.Methods CNKI、VIp、WanFang、CBM、pubMed were searched online to collect randomized controlled trials(RCTs) of Banxia Xiexin Decoction combined with triple therapy for Helicobacter pylori-associated gastritis from inception to January 15， 2020.Eliminate duplicate documents retrieved with EndNoteX7 software.Finalize the included documents strictly according to the inclusion and exclusion criteria， and evaluate the methodologicalquality of the included documents.Meta Analysis with Revman5.3 Software.Resluts Finally included 16 articles.The meta-analysis results show that the total effective rate of Banxia Xiexin Decoction combined with triple therapy in the treatment of HAG [RR=1.25，95%CI (1.19，1.31)，P<0.05]， Hp negative rate [RR=1.26， 95%CI(1.18，1.35)， P<0.05]is better than the control group， and the adverse reaction rate [RR=0.41，95%CI(0.23，0.73)，P<0.05]is smaller than the control group， the differences are statistically significant.Conclusion Compared with western medicine alone， Banxia Xiexin Decoction combined with triple therapy is more effective and safer in treating HAG. However， due to the small number and low quality of the literature included in this study， more and higher quality RCTs are needed to verify the results.
Keywords：Banxia Xiexin Decoction，Triple Therapy，Helicobacter pylori-associated Gastritis，Meta Analysis
幽门螺旋杆菌(Helicobacter pylori，Hp)是一种主要分布于胃黏膜组织中的螺旋形微厌氧菌，感染后能引起慢性炎症[1]。HAG是指Hp感染后引起胃及十二指肠发生炎性变化，从而出现消化道症状。Hp感染是胃炎、胃溃疡、十二指肠溃疡等胃肠疾病的重要病因，并与胃癌的发生关系密切，对人类健康造成严重危害，所以根除Hp对于防治胃肠疾病尤为重要。幽门螺杆菌感染后患者多表现为胃脘部疼痛、胀闷不舒、嗳气、反酸、恶心呕吐、食欲减退等症状。中医从整体观念出发，遵从辨证论治原则，结合临床症状，通常将其归属于胃脘痛、痞满、嘈杂、反酸等病范畴。目前有不少临床研究证实半夏泻心汤联合三联疗法治疗HAG相比于单用西药疗效更好，且安全可靠。本研究收集半夏泻心汤联合三联疗法治疗HAG的RCT，依据循证医学的方法学原理，对其进行Meta分析，系统的探究并评估其治疗HAG的有效性及安全性，以期为临床实践提供参考依据。, 百拇医药(许文娟 彭瑶 刘富林 夏旭婷)