益母草不同炮制品质量研究(1)
【摘 要】 目的：探讨益母草干品、酒益母草、醋益母草以及四制益母草质量，为制定四制益母草质量标准提供数据支持。方法：按照《中国药典(2015年版)》对益母草不同炮制品进行水分、总灰分、二氧化硫及浸出物含量测定;以盐酸水苏碱和盐酸益母草碱作为评价指标，采用高效液相色谱法进行含量测定。结果：益母草不同炮制品水分含量范围为10.9%-11.9%;总灰分含量范围为6.8%-7.9%;二氧化硫未有检出;浸出物含量范围为16.3%-17.8%;盐酸水苏碱含量范围为0.57%-0.68%;盐酸益母草碱含量范围为0.181%-0.194%。结论：益母草不同炮制品水分、总灰分、浸出物及二氧化硫残留均符合药典规定;干益母草盐酸水苏碱、盐酸益母草碱含量最高，四制益母草含量最低，其药理、毒理物质基础有待进一步研究。
【关键词】 益母草;炮制品;四制益母草;质量研究
【中图分类号】R283 【文献标志码】 A 【文章编号】1007-8517(2019)11-0031-04
The Quality Research of Different Processed Products of Leonurus Heterophyllus
WENG Zhiping LIANG Jinjie
Guangdong Xinxing Chinese Medicine School，Yunfu 527400，China
Abstract：Objective To study the quality of dried Leonurus heterophyllus， liquor Leonurus heterophyllus， vinegar Leonurus heterophyllus and Sizhi Leonurus heterophyllus. And provide data support for formulating quality standards of Sizhi heterophyllus. Method According to the Chinese Pharmacopoeia (2015 edition)， determine the contents of water， total ash， sulfur dioxide and extracts in different processed products of Leonurus heterophyllus. And determine the contents of stachydrine hydrochloride and leonurnine hydrochloride by high performance liquid chromatography. Result The moisture content ranged from 10.9% to 11.9%， total ash content ranged from 6.8% to 7.9%， sulfur dioxide was not detected， extract content ranged from 16.3% to 17.8%， stachydrine hydrochloride content ranged from 0.57% to 0.68%， and Leonurus hydrochloride content ranged from 0.181% to 0.194%. Conclusion The contents of moisture， total ash， extracts and sulfur dioxide residues in different processed products of Leonurus heterophyllus were in accordance with the provisions of pharmacopoeia. The contents of stachydrine hydrochloride and Leonurus hydrochloride in dried Leonurus heterophyllus were the highest and those in Sizhi heterophyllus were the lowest. Those pharmacological and toxicological substances need to be further studied.
Keywords：Leonurus Heterophyllus; Processed Products; Sizhi Heterophyllus; Quality Research
益母草為唇形科植物益母草(Leonurus japonicus Houtt.)新鲜或干燥地上部分，其味苦、辛，性微寒;归肝、心包、膀胱经。具有活血调经，利尿消肿，清热解毒之功效。用于月经不调，痛经经闭，恶露不尽，水肿尿少，疮疡肿毒等症[1]，为妇产科要药，故有“益母”之称。益母草分布在全国大部分地区，包括湖北、山东、安徽、江苏、广东、河北、河北等[2]，主要含有生物碱类、黄酮类、二萜类、挥发油类等化学成分[3]，其中《中国药典》含量测定成分为盐酸水苏碱、盐酸益母草碱。
益母草的炮制方法繁多。唐代的《新修本草》，有关于益母草的炮制记载，方法为“捣汁”，是益母草最早的炮制记载。宋代有烧炭炮制法，见于《太平圣惠方》[4]。明代陈嘉谟在《本草蒙荃》中记载“细剉醋炒，马啮堪敷”[5]。清代屠道和在《本草汇纂》中载有“微炒”[6]。清代鲍相璈在《验方新编》中有“烧灰存性”的记载[7]。清代严西亭的《得配本草》中载有“蜜水炒”“酒拌蒸”[8]。, 百拇医药(翁志平 梁锦杰)
【关键词】 益母草;炮制品;四制益母草;质量研究
【中图分类号】R283 【文献标志码】 A 【文章编号】1007-8517(2019)11-0031-04
The Quality Research of Different Processed Products of Leonurus Heterophyllus
WENG Zhiping LIANG Jinjie
Guangdong Xinxing Chinese Medicine School，Yunfu 527400，China
Abstract：Objective To study the quality of dried Leonurus heterophyllus， liquor Leonurus heterophyllus， vinegar Leonurus heterophyllus and Sizhi Leonurus heterophyllus. And provide data support for formulating quality standards of Sizhi heterophyllus. Method According to the Chinese Pharmacopoeia (2015 edition)， determine the contents of water， total ash， sulfur dioxide and extracts in different processed products of Leonurus heterophyllus. And determine the contents of stachydrine hydrochloride and leonurnine hydrochloride by high performance liquid chromatography. Result The moisture content ranged from 10.9% to 11.9%， total ash content ranged from 6.8% to 7.9%， sulfur dioxide was not detected， extract content ranged from 16.3% to 17.8%， stachydrine hydrochloride content ranged from 0.57% to 0.68%， and Leonurus hydrochloride content ranged from 0.181% to 0.194%. Conclusion The contents of moisture， total ash， extracts and sulfur dioxide residues in different processed products of Leonurus heterophyllus were in accordance with the provisions of pharmacopoeia. The contents of stachydrine hydrochloride and Leonurus hydrochloride in dried Leonurus heterophyllus were the highest and those in Sizhi heterophyllus were the lowest. Those pharmacological and toxicological substances need to be further studied.
Keywords：Leonurus Heterophyllus; Processed Products; Sizhi Heterophyllus; Quality Research
益母草為唇形科植物益母草(Leonurus japonicus Houtt.)新鲜或干燥地上部分，其味苦、辛，性微寒;归肝、心包、膀胱经。具有活血调经，利尿消肿，清热解毒之功效。用于月经不调，痛经经闭，恶露不尽，水肿尿少，疮疡肿毒等症[1]，为妇产科要药，故有“益母”之称。益母草分布在全国大部分地区，包括湖北、山东、安徽、江苏、广东、河北、河北等[2]，主要含有生物碱类、黄酮类、二萜类、挥发油类等化学成分[3]，其中《中国药典》含量测定成分为盐酸水苏碱、盐酸益母草碱。
益母草的炮制方法繁多。唐代的《新修本草》，有关于益母草的炮制记载，方法为“捣汁”，是益母草最早的炮制记载。宋代有烧炭炮制法，见于《太平圣惠方》[4]。明代陈嘉谟在《本草蒙荃》中记载“细剉醋炒，马啮堪敷”[5]。清代屠道和在《本草汇纂》中载有“微炒”[6]。清代鲍相璈在《验方新编》中有“烧灰存性”的记载[7]。清代严西亭的《得配本草》中载有“蜜水炒”“酒拌蒸”[8]。, 百拇医药(翁志平 梁锦杰)