【摘 要】 目的：建立蒙成药小儿清肺八味丸的质量控制方法。方法：采用薄层色谱法对小儿清肺八味丸中红花、麦冬、拳参、人工牛黄、胡黄连进行定性鉴别;采用高效液相色谱法测定胡黄连中胡黄连苷Ⅰ和胡黄连苷Ⅱ的含量。结果：薄层鉴别方法专属性强，特征斑点清晰，阴性对照无干扰;胡黄连苷Ⅰ在3.8～76μg/mL范围内与峰面积呈良好线性关系(r=0.9999)，平均回收率为99.71%，RSD为1.03%;胡黄连苷Ⅱ在8.4～168μg/mL范围内与峰面积呈良好线性关系(r=0.9999)，平均回收率为103.30%，RSD为1.95%。结论：所建立的定性、定量分析方法简便、准确、灵敏度高，可用于小儿清肺八味丸的质量控制。

    【关键词】 小儿清肺八味丸;薄层色谱法;高效液相色谱法

    【中图分类号】R917 【文献标志码】 A 【文章编号】1007-8517(2020)3-0027-06

    Abstract：Objective To establish the quality control method of Xiaoer Qingfei Bawei Pills.Methods Carthami flos、Ophiopogonis radix、Bistortae rhizoma、Bovis calculus artifactus and Picrorhizae rhizoma in Xiaoer Qingfei Bawei Pills were identified by TLC.The contents of Picroside Ⅰ and Picroside Ⅱ in Picrorhizae rhizoma were determined by HPLC.Results The identification method was exclusive.The TLC spots were fairly clear ......