摘要: 目的:检测环氧化酶-2(COX-2)在膀胱癌组织中的表达,探讨COX-2表达与膀胱癌临 床病理的关系。方法:采用免疫组化方法检测56例膀胱癌组织中COX-2的表达。结果:膀胱癌 组织中COX-2的阳性表达率为57.1%。COX-2的表达与肿瘤的病理分级和临床分期相关。结 论:COX-2的异常表达可能在膀胱移行细胞癌的发生发展中起一定的作用。

    关键词:膀胱移行细胞癌;环氧化酶-2;免疫组化

    中图分类号: R737.14 文献标识码: A 文章编号: 1008-2409(2009)05-0805-03

    Expression of cyclooxygenase-2 in human transitional cell carcinoma of t he bladder/LU Hao-yuan, BAI Xian-zhong∥The Affiliated Tumor Hospital of Guang xi Medical University, Nanning 530027, China

    Abstract:Objective:To study the expression of cyclooxygenase-2(COX-2) in human transiti onal cel l carcinoma of the bladder(BTCC)and their relationship with clinical pathologic al characteristics. Methods: S-P immunohistochemistry staining was performed t o e valuate the positivity of COX-2 in fifty-six cases of transitional cell carcin om a of the bladder and 10 cases of normal bladder mucosa. Results: The positive e xp ression of COX-2 were 57.1%(32/56), the expression of COX-2 was related tocl inic stage and the tumor grade(P<0.05). Conclusion: The abnormal expressio n of C OX-2 might play a certain role in course of the occurrence, development of tra nsitional cell carcinoma of the bladder. ......