单核巨噬细胞集落刺激因子对人皮肤成纤维细胞增殖及胶原合成的影响(3)
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目前GMCSF作为创面外用药虽然已经应用于临床[10-11],但是对于使用多少浓度才能够最大限度促进创面的愈合尚存在争议,对于促进创面愈合的详细机制也尚未完全清楚。本研究从细胞水平确定了GMCSF对人皮肤成纤维细胞促增殖作用的最适浓度,为临床准确用药提供了可靠的依据;并提示GMCSF促进成纤维细胞增殖及胶原的表达为其加速创面愈合的机制之一。至于GMCSF通过何种机制促进人皮肤成纤维细胞的增殖及胶原表达,这将有待于下一步深入的研究。
[参考文献]
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