ACE在皮肤组织损伤修复与再生中作用的研究(3)
综上所述:ACE作为终止皮肤神经-内分泌介质作用的关键酶可调控皮肤细胞的存活、创伤愈合和组织再生。ACE可作为造血干细胞的标志物和表皮干细胞潜在的标记物,ACE抑制剂可调节干细胞的功能。除Ang I和缓激肽是ACE的底物外,β-内啡肽、P物质、Ac-SDPK等重要的活性物质也是ACE的底物。这些发现强烈提示我们:ACE本身直接或通过调节上述活性物质的含量在皮肤损伤修复、再生过程中发挥作用。因此,积极探讨生理状态下以及创面愈合过程中ACE与皮肤损伤修复与再生之间的关系,以及可能存在的调控作用与机制,对我们更清楚的了解内分泌因素在皮肤组织自我更新、损伤修复与再生等过程中所起的作用具有重要意义。
[参考文献]
[1]张志刚,张国斌. 血管紧张素转化酶生物学作用的新概念[J].生命的化学,1991,11(5):21-23.
[2]Liu H-W,Cheng B,Li JF,et al. Characterization of angiotensin-converting enzyme expression during epidermis morphogenesis in humans: a potential marker for epidermal stem cells[J].Br J Dermatol,2009,160:250-258.
, 百拇医药
[3]Rodgers KE,Abiko M,Girgis W,et al. Acceleration of dermal tissue repair by angiotensin II[J].Wound Repair Regen,1997,5:175-183.
[4]Rodgers K,Xiong S,Felix J,et al. Development of angiotensin(1-7) as an agent to accelerate dermal repair[J].Wound Repair Regen,2001,9(3):238-247.
[5]Rodgers KE,DeChemey AH,St Amand KM,et al.Histologic alterations in dermal repair after thermal injury effects of topical angiotensin II. J Burn Care Rehabil,1997,18(5):381-388.
, 百拇医药
[6]Okuyama N,Roda N,Sherman R,et al.Angiotebsin II improves random-flap viability in a rat model[J].Ann Plast Surg,1999,42(3):313-319.
[7]刘宏伟,程飚,付小兵. 增生性瘢痕中血管紧张素转化酶表达及血管紧张素II产生的变化[J].中国美容医学,2006,15(4):358-360.
[8]刘宏伟,程飚. 血管紧张素II受体与皮肤组织损伤后的修复[J].中国临床康复,2005,9(34):127-129.
[9]Fleming I. Signaling by the angiotensin-converting enzyme[J].Circ Res,2006, 98: 887-896.
, 百拇医药 [10]Mayer S,Izydorczyk I, Reeh P W, et al. Bradykinin-induced nociceptor sensitisation to heat depends on cox-1 and cox-2 in isolated rat skin[J].Pain,2007,130:14-24.
[11]Koppert W,Martus P,Reeh PW,et al. Interactions of histamine and bradykinin on polymodal C-fibers in isolated rat skin[J].Eur J Pain,2001,5:97-106.
[12]Adam A,Leclair P,Montpas N,et al. Altered cardiac bradykinin metabolism in experimental diabetes caused by the variations of angiotensin-converting enzyme and other peptidases[J].Neuropeptides,2010,44: 69-75.
, http://www.100md.com
[13]Steckelings UM,Wollschlager T,Peters J,et al. Human skin: source of and target organ for angiotensin II[J].Exp Dermatol,2004,13:148-154.
[14]Maria A,Cavasin,Tang-Dong Liao,et al. Decreased Endogenous Levels of Ac-SDKP Promote Organ Fibrosis[J].Hypertension,2007,50:130-136.
[15]Lombard MN,Sotty D,Wdzieczak-Bakala J,et al.In vivo effect of the tetrapeptide,N-acetyl-Ser-Asp-Lys-Pro,on the G1-S transition of rat hepatocytes[J].Cell Tissue Kinet,1990,23:99-103.
, 百拇医药
[16]Cheng B,Liu H-W,Fu X-B,et al. Coexistence and upregulation of three types of opioid receptors, mu, delta and kappa, in human hypertrophic Scars[J].Br JDermatol,2008,158:713-720.
[17]Bigliardi-Qi M,Sumanovski LT,Buchner S,et al. Mu-opiate receptor and beta-endorphin expression in nerve endings and keratinocytes in human skin[J].Dermatol,2004,209:183-189.
[18]程飚,刘宏伟,付小兵,等. β内啡肽与μ型阿片受体在深Ⅱ度烫伤大鼠创面愈合过程中的表达[J].中华烧伤杂志,2007,23(1):36-39.
, http://www.100md.com
[19]Liu LP,Fan WX,Dai YQ,et al. Effects of β-endorphin in the skin[J].J Clinic Dermatol,2006,35:192-193.
[20]Jokubaitis VJ,Sinka L,Driessen R,et al. Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic,fetal,and adult hematopoietic tissues[J].Blood,2008,111: 4055-4063.
[收稿日期]2010-06-10 [修回日期]2010-07-13
编辑/张惠娟, http://www.100md.com(李升红 刘宏伟 程 飚)
[参考文献]
[1]张志刚,张国斌. 血管紧张素转化酶生物学作用的新概念[J].生命的化学,1991,11(5):21-23.
[2]Liu H-W,Cheng B,Li JF,et al. Characterization of angiotensin-converting enzyme expression during epidermis morphogenesis in humans: a potential marker for epidermal stem cells[J].Br J Dermatol,2009,160:250-258.
, 百拇医药
[3]Rodgers KE,Abiko M,Girgis W,et al. Acceleration of dermal tissue repair by angiotensin II[J].Wound Repair Regen,1997,5:175-183.
[4]Rodgers K,Xiong S,Felix J,et al. Development of angiotensin(1-7) as an agent to accelerate dermal repair[J].Wound Repair Regen,2001,9(3):238-247.
[5]Rodgers KE,DeChemey AH,St Amand KM,et al.Histologic alterations in dermal repair after thermal injury effects of topical angiotensin II. J Burn Care Rehabil,1997,18(5):381-388.
, 百拇医药
[6]Okuyama N,Roda N,Sherman R,et al.Angiotebsin II improves random-flap viability in a rat model[J].Ann Plast Surg,1999,42(3):313-319.
[7]刘宏伟,程飚,付小兵. 增生性瘢痕中血管紧张素转化酶表达及血管紧张素II产生的变化[J].中国美容医学,2006,15(4):358-360.
[8]刘宏伟,程飚. 血管紧张素II受体与皮肤组织损伤后的修复[J].中国临床康复,2005,9(34):127-129.
[9]Fleming I. Signaling by the angiotensin-converting enzyme[J].Circ Res,2006, 98: 887-896.
, 百拇医药 [10]Mayer S,Izydorczyk I, Reeh P W, et al. Bradykinin-induced nociceptor sensitisation to heat depends on cox-1 and cox-2 in isolated rat skin[J].Pain,2007,130:14-24.
[11]Koppert W,Martus P,Reeh PW,et al. Interactions of histamine and bradykinin on polymodal C-fibers in isolated rat skin[J].Eur J Pain,2001,5:97-106.
[12]Adam A,Leclair P,Montpas N,et al. Altered cardiac bradykinin metabolism in experimental diabetes caused by the variations of angiotensin-converting enzyme and other peptidases[J].Neuropeptides,2010,44: 69-75.
, http://www.100md.com
[13]Steckelings UM,Wollschlager T,Peters J,et al. Human skin: source of and target organ for angiotensin II[J].Exp Dermatol,2004,13:148-154.
[14]Maria A,Cavasin,Tang-Dong Liao,et al. Decreased Endogenous Levels of Ac-SDKP Promote Organ Fibrosis[J].Hypertension,2007,50:130-136.
[15]Lombard MN,Sotty D,Wdzieczak-Bakala J,et al.In vivo effect of the tetrapeptide,N-acetyl-Ser-Asp-Lys-Pro,on the G1-S transition of rat hepatocytes[J].Cell Tissue Kinet,1990,23:99-103.
, 百拇医药
[16]Cheng B,Liu H-W,Fu X-B,et al. Coexistence and upregulation of three types of opioid receptors, mu, delta and kappa, in human hypertrophic Scars[J].Br JDermatol,2008,158:713-720.
[17]Bigliardi-Qi M,Sumanovski LT,Buchner S,et al. Mu-opiate receptor and beta-endorphin expression in nerve endings and keratinocytes in human skin[J].Dermatol,2004,209:183-189.
[18]程飚,刘宏伟,付小兵,等. β内啡肽与μ型阿片受体在深Ⅱ度烫伤大鼠创面愈合过程中的表达[J].中华烧伤杂志,2007,23(1):36-39.
, http://www.100md.com
[19]Liu LP,Fan WX,Dai YQ,et al. Effects of β-endorphin in the skin[J].J Clinic Dermatol,2006,35:192-193.
[20]Jokubaitis VJ,Sinka L,Driessen R,et al. Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic,fetal,and adult hematopoietic tissues[J].Blood,2008,111: 4055-4063.
[收稿日期]2010-06-10 [修回日期]2010-07-13
编辑/张惠娟, http://www.100md.com(李升红 刘宏伟 程 飚)