三种光疗法治疗寻常性痤疮疗效观察(1)
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[摘要]目的:评价光动力学疗法(PDT),强脉冲光(IPL)和红蓝光(LED)治疗中、重度寻常性痤疮的疗效。方法:将90例中、重度痤疮患者随机分为三组:PDT治疗组,IPL治疗组和LED红蓝光治疗组。分别于治疗前、治疗中期(治疗1个月)和末次治疗结束后评价疗效。结果:治疗中期评价时,PDT、IPL、LED治疗组总有效率分别为93.3%、60.0%和36.7%,平均皮损减少率分别为90.4%、69.0%和39.8%。要达到炎症性皮损痊愈,PDT组平均需要(3±1.52)个治疗周期,IPL组(6±2.15)个治疗周期,LED组(9±3.34)个治疗周期。结论:光疗法治疗中、重度痤疮疗效显著,PDT组疗法效果优于IPL和LED组,副作用少,有很好应用前景,而长期疗效有待进一步观察。
[关键词]光动力学疗法;强脉冲光;红蓝光;寻常性痤疮
[中图分类号]R758.73+3 [文献标识码]A [文章编号]1008-6455(2010)10-1515-03
Effectiveness of three phototherapy in the treatment of acne vulgaris
LIU Li-hong, WANG Cong-min, FAN Xin, YAO Mei-hua, SUN Wei-xin, YANG Rong-ya
(Department of Dermatology,General Hospital of Beijing Military Region of PLA, Beijing 100125,China)
Abstract: ObjectiveTo evaluate the effectiveness of photodynamic therapy (PDT), intense pulsed light (IPL) and light-emitting diode (LED) phototherapy for the treatment of moderate to severe acne vulgaris.Methods90 patients with moderate to severe acne were randomly divided into 3 equal groups:ALA-PDT group, IPL group, blue-red combination LED group.Clinical assessments were conducted before starting treatment, at 1 month as a midpoint evaluation, and after the final treatment session. ResultsAt the mid-point evaluation, in case of PDT, IPL and LED groups, the effective rate were 93.3%,60.0%,36.7%,respectively, and the percent reductions were 90.4%,69.0%,39.8%,respectively.Patients treated with the PDT reached a≥90% clearance of their inflammatory lesions after a mean of 3±1.52 sessions, while patients treated with IPL required a mean of 6±2.15 sessions. Patients treated with the LED required a mean of 9±3.34 sessions.ConclusionsPhototherapy is effective treatment option for moderate to severe acne with mild side effects. Effectiveness of PDT is the best in the three group. Validates further studies to evaluate treatments for a longer effectives.
Key words: photodynamic therapy;intense pulsed light;light-emitting diode;acne vulgaris
寻常性痤疮为炎症反应引起的丘疹、脓疱、结节,伴发或不伴发非炎症性粉刺,好发于青春期,轻者可为生理性粉刺,重者可因炎症有碍面部美观。目前,痤疮的治疗方法很多,抗生素和维A酸类药物是其主要治疗方法,但疗效不稳定。光疗是一种有效的治疗寻常性痤疮的新方法,研究显示可见光的光疗,红蓝光对炎症性痤疮具有明显的治疗效果,副作用小[1]。卟啉在IPL发射谱内有小的吸收峰,以不同均质的组织为靶点,光可选择性被吸收,IPL可作为治疗痤疮的光源[2] ......
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