果酸治疗中度寻常型痤疮疗效及安全性研究(1)
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[摘要]目的：评价果酸和5%过氧苯甲酰凝胶治疗中度痤疮的疗效和安全性。方法：采用随机对照的临床试验，试验组患者用不同浓度的果酸治疗，每2周1次，连续治疗6次；对照组患者给予5%过氧苯甲酰凝胶外用，每日2次。两组患者均连用12周，按炎性皮损(丘疹、脓疱)与非炎性皮损(粉刺)分别观察皮损数目的变化，每4周观察并记录两组痤疮患者的粉刺、丘疹、脓疱数量，做评分比较。结果：试验组有效率为86.7%,对照组为51.6%，二组间疗效比较差异有显著性(P <0.05)。试验组有2例患者，对照组有5例患者出现局部不良反应。结论：果酸换肤是一种有效、安全治疗痤疮的方法。
[关键词]痤疮；果酸；过氧苯甲酰凝胶
[中图分类号]R758.73+3[文献标识码]A [文章编号]1008-6455(2011)01-0098-03
Clinical efficacy and safety research of alpha hydroxy acid in the treatment of medium degree acne vulgaris
HUANG Ming-huan, HUANG yi
(Medical cosmetic department, East hospital affiliated Tongji university, Shanghai, 200120,China)
Abstract： Objective To evaluate the clinical efficacy and safety of alpha hydroxy acid and benzoyl peroxide gels in the treatment of medium degree acne vulgaris. Methods A randomized controlled clinical study was performed by 61 patients with medium degree acne vulgaris. The test group was treated with a series of alpha hydroxy acid peelings with different concentrations every two weeks at least 6 sessions, which were treated with benzoyl peroxide gel used on the surface of the skin twice per day for 12 weeks. The number of comedo, papules, pustules and sebum excretion were counted and recorded in the end of every four weeks. Results There was significant difference between the two groups. After 12-week-treatment, the total effective rates were 86.7% in alpha hydroxy acid group, and 56.7% in the control group (P< 0.05). There were 2 patients with the local adverse reactions in the alpha hydroxy acid group and 5 patients with side reactions in the control group. Conclusion alpha hydroxy acid is an effective and safety method for medium degree acne vulgaris.
Key words：acne vulgaris; alpha hydroxy acid; benzoyl peroxide gel
痤疮是一种发生在毛囊、皮脂腺及周围组织的炎症性病变,形成粉刺、丘疹、脓疱、结节、囊肿等皮肤损害，青春期较常见。由于其发病机制复杂,临床上治疗较困难。随着美容医学的发展，果酸换肤治疗作为一种新的治疗手段,取得了良好疗效。它通过促进皮肤再生、真皮重建和抑制痤疮丙酸杆菌的生长来达到治疗痤疮的目的。2009年8月～2010年8月，我们采用随机对照的临床研究方法,应用5%过氧苯甲酰凝胶(商品名:班赛,法国高德美国际公司)和不同浓度(20%、35%、50%、70%)的果酸(美国Neostrata的羟基乙酸系列)治疗中度痤疮,并进行疗效观察和安全性评价，现报道如下。
1 资料和方法
1.1 病例选择
1.1.1入选标准：入选患者均为我科门诊就诊者,根据Pillsbury分类法[1],选择具有典型的中度面部寻常型痤疮的临床表现 ......
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