外源性神经生长因子对外周神经侧枝发芽GAP-43表达的调控(2)
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本实验发现损伤后神经远端GAP-43表达增高，从1周开始增强，至4周左右达到高峰，8周左右开始减弱，说明随着神经再生的成功，GAP-43表达逐步下调。NGF组与SAL组相比，免疫反应阳性强度增加明显，表明NGF可以上调GAP-43，从而促进神经的再生。出芽过程在损伤早期即开始,神经元胞体开始合成神经再生所需的各类因子,然后由轴浆运输至再生部位。靶肌肉注射既可增加局部NGF的含量，为侧支出芽创造良好的内外环境,又可上调神经再生所需其它因子的表达，从而促进神经侧枝发芽。
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