预构皮瓣再血管化的研究进展(2)
预构皮瓣已成为治疗复杂的畸形和缺损，尤其是颜面部畸形缺损的理想手段，但是如何有效缩短血管化进程、诱导血管新生是有待解决的问题。生长因子疗法普遍认为具有起效速度快，量效曲线稳定等优点，同时也存在着诸如无法形成结构功能完整血管、半衰期短等缺点。基因治疗存在着感染病毒的危险。细胞治疗已证实能够促进新生血管的形成，细胞最佳植入方法和时间问题以及植入细胞是通过何种机制来调控血管形成这一复杂过程是今后进一步的研究方向。
[参考文献]
[1]Yao ST.Microvascular transplantation of prefabricated free thigh flap[J].Plast Reconstr Surg,1982，69(3):568.
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, 百拇医药
[3]Iwasawa M.Accelerated maturation in prefabricated flaps by transforming growth factor-beta: an experimental study in the rabbit [J].Ann Plast Surg,1993,31(1):72-75.
[4]Haws MJ,Erdman D,Bayati S,et alBasic fibroblast growth factor induced angiogenesis and prefabricated flap survival [J].J Reconstr Microsurg，2001，17(1)：39-42.
[5]Hijjawi J,Mogford JE,Chandler LA,et al.Platelet-derived growth factor B, but not fibroblast growth factor 2, plasmid DNA improves survival of ischemic myocutaneous flaps [J].Arch Surg,2004,139(2):142-147.
, 百拇医药
[6]Li QF,Reis ED,Zhang WX,et al.Accelerated flap prefabrication with vascular endothelial growth factor [J]. J Reconstr Microsurg,2000,16(1):45-49.
[7]黄晨昱，沈祖尧.血管内皮细胞生长因子和碱性成纤维细胞生长因子加速预构扩张皮瓣成熟的研究[J].中国修复重建外科杂志，2003，17(4)：293-297.
[8]Gurunluoglu R，Meirer R，Shafighi M，et a1.Gene therapy with adenovirus-mediated VEGF enhances skin flap prefabrication[J].Microsurgery，2005，25(5)：433-441.
[9]丁 志，郑江红，邓智明,等. 腺病毒-VEGF基因重组体促进预构皮瓣成活的实验研究[J].中国美容医学，2009,18(3)：332-335.
, 百拇医药
[10]Simons M.Angiogenesis: where do we stand now [J]? Circulation,2005,111(12):1556-1566.
[11]Asahara T,Masuda H,Takahashi T,et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization[J].Circ Res,1999,85(3):221-228.
[12]Schuleri KH,Boyle AJ,Hare JM.Mesenchymal stem cells for cardiac regenerative therapy [J].Handb Exp Pharmacol,2007,180:195-218.
, http://www.100md.com
[13]Fu X,Fang L,Li X,et al.Enhanced wound-healing quality with bone marrow mesenchymal stem cells autografting after skin injury [J].Wound Repair Regen，2006,14(3):325-335.
[14]郑 岩，易成刚，郭树忠.转基因的骨髓间充质干细胞治疗大鼠缺血皮瓣[J].中华实验外科杂志，2007,24(3):339-341.
[15]Stenderup K,Justesen J,Clausen C,et al.Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells[J].Bone,2003,33(6):919-926.
, 百拇医药
[16]Park S,Tepper OM,Galiano RD,et al.Selective recruitment of endothelial progenitor cells to ischemic tissues with increased neovascularization [J].Plast Reconstr Surg,2004,113(1):284-293.
[17]Lyden D,Hattori K,Dias S,et al.Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth [J].Nat Med,2001,7(11):1194-1201.
[18]Edelberg JM,Tang L,Hattori K,et al.Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function[J].Circ Res,2002,90(10):E89-93.
[19]Zhang ZG,Zhang L,Jiang Q,et al.Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse[J].Circ Res,2002,90(3):284-288., 百拇医药(马旭 杨大平)
[参考文献]
[1]Yao ST.Microvascular transplantation of prefabricated free thigh flap[J].Plast Reconstr Surg,1982，69(3):568.
[2]Asahara T,Murohara T,Sullivan A,et al.Isolation of putative progenitor endothelial cells for angiogenesis[J].Science,1997,275(5302):964-967.
, 百拇医药
[3]Iwasawa M.Accelerated maturation in prefabricated flaps by transforming growth factor-beta: an experimental study in the rabbit [J].Ann Plast Surg,1993,31(1):72-75.
[4]Haws MJ,Erdman D,Bayati S,et alBasic fibroblast growth factor induced angiogenesis and prefabricated flap survival [J].J Reconstr Microsurg，2001，17(1)：39-42.
[5]Hijjawi J,Mogford JE,Chandler LA,et al.Platelet-derived growth factor B, but not fibroblast growth factor 2, plasmid DNA improves survival of ischemic myocutaneous flaps [J].Arch Surg,2004,139(2):142-147.
, 百拇医药
[6]Li QF,Reis ED,Zhang WX,et al.Accelerated flap prefabrication with vascular endothelial growth factor [J]. J Reconstr Microsurg,2000,16(1):45-49.
[7]黄晨昱，沈祖尧.血管内皮细胞生长因子和碱性成纤维细胞生长因子加速预构扩张皮瓣成熟的研究[J].中国修复重建外科杂志，2003，17(4)：293-297.
[8]Gurunluoglu R，Meirer R，Shafighi M，et a1.Gene therapy with adenovirus-mediated VEGF enhances skin flap prefabrication[J].Microsurgery，2005，25(5)：433-441.
[9]丁 志，郑江红，邓智明,等. 腺病毒-VEGF基因重组体促进预构皮瓣成活的实验研究[J].中国美容医学，2009,18(3)：332-335.
, 百拇医药
[10]Simons M.Angiogenesis: where do we stand now [J]? Circulation,2005,111(12):1556-1566.
[11]Asahara T,Masuda H,Takahashi T,et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization[J].Circ Res,1999,85(3):221-228.
[12]Schuleri KH,Boyle AJ,Hare JM.Mesenchymal stem cells for cardiac regenerative therapy [J].Handb Exp Pharmacol,2007,180:195-218.
, http://www.100md.com
[13]Fu X,Fang L,Li X,et al.Enhanced wound-healing quality with bone marrow mesenchymal stem cells autografting after skin injury [J].Wound Repair Regen，2006,14(3):325-335.
[14]郑 岩，易成刚，郭树忠.转基因的骨髓间充质干细胞治疗大鼠缺血皮瓣[J].中华实验外科杂志，2007,24(3):339-341.
[15]Stenderup K,Justesen J,Clausen C,et al.Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells[J].Bone,2003,33(6):919-926.
, 百拇医药
[16]Park S,Tepper OM,Galiano RD,et al.Selective recruitment of endothelial progenitor cells to ischemic tissues with increased neovascularization [J].Plast Reconstr Surg,2004,113(1):284-293.
[17]Lyden D,Hattori K,Dias S,et al.Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth [J].Nat Med,2001,7(11):1194-1201.
[18]Edelberg JM,Tang L,Hattori K,et al.Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function[J].Circ Res,2002,90(10):E89-93.
[19]Zhang ZG,Zhang L,Jiang Q,et al.Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse[J].Circ Res,2002,90(3):284-288., 百拇医药(马旭 杨大平)