平阳霉素加曲安奈德瘤体内注射治疗婴幼儿体表血管瘤(1)
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[摘要]目的：探讨平阳霉素加曲安奈德瘤体局部注射治疗婴幼儿体表血管瘤的疗效。方法：以平阳霉素加曲安奈德瘤体内注射治疗婴幼儿体表血管瘤，皮损最大6cm×6cm，最小1cm×1cm，15天注射1次，3～5次为1个疗程。对2004年3月～2009年3月治疗的150例患儿进行了1～6年的随访观察，将临床资料进行分析。结果：经过1～6年随访，治愈121例，显效29例，无效0例，治愈率80.66%，有效率100%。结论：平阳霉素加曲安奈德局部注射治疗婴幼儿体表血管瘤具有疗效高、疗程短，副作用少等优点，是一种简便、安全有效的方法。
[关键词]平阳霉素；曲安奈德；婴幼儿；血管瘤
[中图分类号]R732.2 [文献标识码]A[文章编号]1008-6455(2011)07-1125-03
Local combination injection of Bleomycin A5 and triamcinolone acetonid for the treatment of infantile superficial hemangioma
LIU Yan
(Department of Dermatology, The Central Hospital of Hanzhong, Hanzhong 723000, Shaanxi, China)
Abstract: ObjectiveTo investigate the clinical effect of local combination injection of bleomycin A5 and triamcinolone acetonid for the treatment of infantile superficial hemangioma.Methods150 cases of infantile superficial hemangioma were treated by local combination injection of bleomycin A5 and triamcinolone acetonid, the area of biggest lesions was 6cm×6cm, and the smallest was 1cm×1cm, the injection was repeated every 15 days，and 3～5 times for one course of treatment. These 150 cases were followed up for 1～6 years from 2004.3 to 2009.3，and clinical data was statistically analyzed. ResultsAfter followed up for 3～6 years,121 cases got cure, 29 cases marked effectiveness, and no one cases was ineffective，the cure rate was 80.66% and the effective rate was 100%. ConclusionCombined infection therapy of bleomycin A5 and triamcinolone acetonide for the treatment of infantile superficial hemangioma is a good method, it has the advantage of high efficacy,Short-term treatment and fewer side effects,it is simple,safe and effective.
Key words: Bleomycin A5;triamcinolone acetonid;infantile；hemangioma
婴幼儿血管瘤具有明显的自然消退特征，大部分病例经过出生后1个月及4～6个月的两个快速生长期，1岁左右生长停滞，进入稳定期并逐渐消退[1]，但也有相当一部分病例消退缓慢甚至不能自行消退[2]。如生长过快，将迅速造成较大范围的皮肤美容损害，尤其是头面部，除了造成美容缺陷外，还可引起相应的功能障碍，给患者及亲属带来极大的精神创伤和心理负担。所以笔者主张早发现早治疗，可选择比较温和的不会造成继发皮肤损害的治疗方法。2004年3月～2009年3月，笔者科室采用较低浓度和较小剂量的平阳霉素加曲安奈德局部注射治疗体表血管瘤患儿150例(共203个皮损)，有效地控制瘤体的发展并最终治愈，取得了满意疗效，现总结报道如下。
1资料和方法
1.1 临床资料：本组共150例患儿，其中男47例，女113例，年龄1个月～2岁，均为血管瘤(旧称草莓状血管瘤)[3]。病变部位：头面部96例，四肢21例，躯干28例，会阴及生殖器5例。皮损最大6cm×6cm，最小1cm×1cm。
1.2 治疗方法：所有患儿每次注射治疗均留院观察1～3天 ......
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