丹参酮联合多西环素治疗炎症性痤疮的临床观察(1)
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[摘要]目的：观察丹参酮短程联合多西环素治疗炎症性痤疮的疗效和复发情况。方法：将150例痤疮患者随机分为A、B、C三组，每组各50例。A组：口服多西环素100mg，2次/天，4周后改为1次/天；B组：口服丹参酮胶囊1g，3次/天；C组：口服多西环素100mg，2次/天，2周后停用，丹参酮胶囊1g，3次/天，8周为一个疗程。结果：B、C两组有效率均明显高于A组，第1、2周C组有效率明显高于A、B组，B、C两组复发率均明显低于A组。结论：丹参酮胶囊早期、短程联合多西环素治疗炎症性痤疮疗效优于单用多西环素，且起效比单用丹参酮快，复发率低，不良反应轻微。
[关键词]丹参酮；多西环素；痤疮
[中图分类号]R758.73+3[文献标识码]A [文章编号]1008-6455(2011)07-1129-02
Clinical observation of Tanshinone in combination with Doxycycline on treatment Of inflammatory acne
PU Jie，YANG Ting，SHAO Min-hua,SHI He-jian
(Department of Dermatology, Wuxi People's Hospital,Wuxi 214023，Jiangsu，China)
Abstract： Objective To observe therapeutic effect and recurrence of tanshinone in short-term combination with doxycycline on inflammatory acne.Methods 150 cases of patients with acne vulgaris were randomly divided into Group A, B and C. Each group were 50 cases.Group A was given Doxycycline 100mg,2 times a day for 4 weeks and then 1 time a day. Group B was given tanshinone capsule 1g, 3 times a day. Group C was given Doxycycline 100mg,2 times a day for 2 weeks and tanshinone capsule 1g, 3 times a day,8 weeks for a course.ResultsThe efficiency of Group B and C were significantly higher than that of Group A.The efficiency of Group C was significantly higher than that of Group A and Group B at week 1 and 2.The recurrence of Group B and C were significantly lower than that of Group A. Conclusion Tanshinone capsule in early,short-term combination with Doxycycline was more effective than Doxycycline alone in treatment of inflammatory acne and the onset time was faster than that of tanshinone alone with low reurrence and mild side effects.
Key words:tanshinone; Doxycycline; acne
痤疮是青春期常见的一种毛囊皮脂腺慢性炎症，痤疮本身的皮损及其产生的后遗色素斑、瘢痕，可造成美容问题，对患者心理、社交产生一定的影响。以丘疹、脓疱为主要表现的炎症性痤疮是这一损容性皮肤病中最常见到的类型，为迅速、有效控制痤疮炎症，2009年7月～2010年7月，笔者采用丹参酮胶囊早期、短程联合多西环素治疗患者，取得了较好疗效，现报道如下。
1资料和方法
1.1病例选择:150例均为我院皮肤科门诊患者，年龄14～31岁,平均为20.7岁，其中男88例，女72例，病程1个月～10年，平均病程3.3年。诊断标准：为《临床皮肤病学》中寻常性痤疮的诊断，并采用Pillsbury分类法，仅Ⅱ～Ⅲ度患者入选[1]。排除标准：①治疗前1个月内使用过其他方法及治疗药物；②对治疗药物过敏者；③妊娠或哺乳期妇女；④肝功能不全者；⑤患有其他面部皮肤病如脂溢性皮炎、湿疹、日光性皮炎等可能干扰疗效判断者。150例患者被随机分为三组：A组(多西环素组)，B组(丹参酮组)，C组(联合用药组)，各50例，三组患者的年龄、性别、病程均无统计学差异。治疗前后查血、尿常规及肝肾功能 ......
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