溶菌酶肠溶片联合冷冻治疗扁平疣疗效观察(1)
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[摘要]目的：探讨溶菌酶肠溶片联合液氮冷冻治疗扁平疣的临床疗效及并发症，比较溶菌酶肠溶片联合液氮冷冻与单用液氮冷冻或单纯服用溶菌酶肠溶片治疗扁平疣的临床疗效。方法：将140例扁平疣患者随机分为三组，治疗组:55例，溶菌酶肠溶片联合液氮冷冻治疗；对照1组：45例，单纯用液氮冷冻治疗；对照2组：40例，单纯服用溶菌酶肠溶片。均采用五级分类法来统计并判断疗效情况，观察三组的临床疗效及近期、远期并发症。结果：治疗组总有效率达92.73%，对照1组总有效率66.67%,对照2组总有效率57.50%。治疗组分别与对照1、2组比较,具有显著性差异，(χ12=10.92，χ22=16.69,P<0.05)具有统计学意义。结论：溶菌酶肠溶片联合液氮冷冻治疗扁平疣临床疗效好，而且并发症较少。
[关键词]扁平疣；溶菌酶肠溶片；冷冻
[中图分类号]R752.5+2[文献标识码]A[文章编号]1008-6455(2011)07-1131-02
Lysozyme Entric-coated tablets combined cryotherapy verruca plana clinical efficacy
WANG Ming-zhi
(Departmentof Dermatology,Hou jie Hospitalof Dongguan City,Dongguan523945, Guangdong,China)
Abstract:Objective To exploreLysozymeEntric-coated tabletscombined liquid-nitrogen cryotherapy clinical efficacy and complications,compared Lysozyme Entric-coated tablets combined liquid-nitrogen cryotherapy and single liquid-nitrogen cryotherapy or pure taking Lysozyme Entric-coated tablets,the clinical efficacy of verruca plana.Methods140 cases of patients with verruca plana were randomly divided into three groups,55 patients treated Lysozyme Entric-coated tablets combined liquid-nitrogen cryotherapy, the control 1 group ：45 cases of cryotherapy with liquid-nitrogen;the control 2 group：40cases of pure taking Lysozyme Entric-coated tablets.By 5 classification to statistics and judging curative effect. Observe three groups clinical efficacy and the recent, long-term complications. ResultsThe treatment group total effective were 92.73%; control group 1 66.67%; control group 2 57.50% .Treatment groups were compared with the control group 1，2 having significant differences (χ12=10.92，χ22=16.69,P<0.05) with statistical significance. ConclusionsClinical efficacy of Lysozyme Entric-coated tablets combined liquid-nitrogen cryotherapy is good, and fewer complications.
Key words: verruca plana; LysozymeEntric-coated tablets;freezing
扁平疣是临床常见的一种病毒性皮肤病，好发于青少年的颜面和手背，典型皮损为米粒到黄豆大扁平隆起性丘疹、褐色或皮肤色，数目较多且密集[1]。以往常采用中医中药及电灼、化学腐蚀剂、细胞毒剂、连续性CO2激光等局部治疗，治疗效果不明显，且局部治疗深浅度不易掌握，易出血、形成瘢痕等。2006年1月～2010年12月，笔者应用溶菌酶肠溶片联合液氮冷冻治疗扁平疣患者，取得了良好的临床疗效，现报道如下。
1资料和方法
1.1临床资料：选择门诊就医、具有典型临床症状的扁平疣患者140例，随机分为三组：治疗组：55例，其中男18例、女37例，年龄14～50岁，平均为(26.3±1.5)岁，病程0.5～6年，平均为(1.8±0.5)年 ......
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