Ad-EGFP修饰的MSCs在糖尿病足溃疡大鼠体内的示踪及疗效观察(3)
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因STZ是通过破坏胰岛β细胞功能而致糖尿病，因此胰腺组织破坏最严重，高表达许多种趋化因子，诱使BMSCs 向着胰腺归巢；糖尿病往往伴随有肾脏的损害，故肾脏组织也可见到干细胞归巢现象。糖尿病患者下肢动脉慢性闭塞，形成的溃疡因组织缺血缺氧而迁延不愈，静脉给药对于下肢血流尚通畅的还有一定效果，对于下肢血流阻塞的效果却不理想。该实验在2型糖尿病模型造模成功后1周即开始给予静脉BMSCs移植治疗，下肢微血管病变尚未形成血流完全闭塞的情况，故静脉移植细胞后在溃疡局部可见BMSCs. 然而，就干细胞是因为降低血糖才促进创面愈合的，还是直接的促创面愈合机制，有待进一步研究。
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[收稿日期]2011-06-11 [修回日期]2011-08-14
编辑/张惠娟
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