兔肋软骨膜对肋软骨移植后生物力学性能影响的研究(1)
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[摘要]目的：探讨新西兰大白兔肋软骨膜对肋软骨自体异位移植后生物力学的影响，为临床上选取最佳肋软骨移植物提供理论依据。方法：6周龄新西兰大白兔6只，取单侧6、7、8带软骨膜肋软骨，每个标本随机分为等长两段，一段保留软骨膜，一段去除软骨膜，分别埋植于兔的背部两侧对称部位。于12周后取出两组埋植软骨，剥去带肋软骨膜者的软骨膜，埋植前不带肋软骨膜者不作处理。据试验机要求制成相应大小标准试件。采用SHIMADZU(日本，AGS-X型)试验机行拉伸、压缩和弯曲试验。结果：带软骨膜组肋软骨极限抗拉强度及最大拉伸应变、最大压缩强度及最大压缩应变、最大弯曲强度及弯曲破坏时间均大于不带软骨膜组，两组之间差异有统计学意义(P<0.05)。结论：带软骨膜肋软骨生物力学性能优于不带软骨膜者。
[关键词]兔；肋软骨；软骨膜；生物力学
[中图分类号]R622 R332 [文献标识码]A [文章编号]1008-6455(2012)04-0579-03
Effect of costal perichondrium on biomechanics of transplanted costicartilage in rabbits
JIANG Shan,CHEN Zhen-yu,ZHU Yue-hua,LENG Xiang-feng,ZHANG Wei-na
(Department of Plastic Surgery,Affiliated Hospital of Medical College,Qingdao University,Qingdao 266000,Shandong,China)
Abstract: Objective To study the differences of the cartilage with and without the perichondrium after autologous ectopic transplantation in healthy rabbits,in order to offer theory reference for clinic to make the best use of cartilage. Methods 6 rabbits at the age of six weeks.Each of them the sixth,seventh,and eighth costal cartilages with perichondrium were removed,and divided into two segments at the even length,one segment with perichondrium and the other non-perichondrium.They were buried under the skin of the back at bilaterally symmetrical parts.Two different groups of cartilages were took out after 12 weeks and removed the perichondrium of the cartilages that had it previously. Tensile,compressive and flexural tests were conducted by using SHIMADZU material testing machine. Results The average maximum strength and the strain of tension,compression and flexion of the perichondrium group were higher than those in the non- perichondrium group(P<0.05). Conclusion Biomechanics of costicartilage with perichondrium are superior to those without it after autologous ectopic transplantation.
Key words:rabbit;costicartilage;perichondrium;biomechanics
肋软骨是一种透明软骨，组织具有弹性，移植后易成活，与其他组织相比不易变形，是理想的填充、塑形以及支持材料。自体肋软骨因与机体组织生物相容性佳，无排斥反应，抗感染能力强等优点而被广泛应用于多种整形外科手术，如耳再造、隆鼻等[1]。
肋软骨的生物力学性能对手术效果具有十分重要的影响，具有良好生物力学性能的肋软骨可更好地对抗各种外力作用，取得并维持更为理想的手术效果。现阶段，国内外已有不少对软骨生物力学性能的研究，但大多数以其它部位的软骨为研究对象，如关节软骨等。即使有少量研究肋软骨生物力学性能的，也未能系统阐述肋软骨膜对其的影响[2-3]。已有大量研究表明，肋软骨膜能够促进肋软骨的生长并有利于其塑形[4]，但其对肋软骨生物力学性能的直接影响仍不确定。本研究正是针对上述不足，通过实验研究兔健康肋软骨的极限抗拉强度 ......
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