皮肤色素及厚度对皮肤光敏感性的影响(1)
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[摘要]目的：研究皮肤色素及厚度对皮肤光敏感性的影响。方法：采用日光防护指数测定仪对31名健康志愿者后背及臀部皮肤进行照射，获取两种波长紫外线照射下的最小红斑量(minimal erythema dose,MED)和最小持续性黑化量(minimal persistent pigment darkening dose,MPPD)。照射前用皮肤黑素和红色素测定仪、皮肤扫描比分光光度仪和皮肤B超测定试验部位。结果：MPPD与b*、MI、Depth呈负相关，MED与b*、MI、Depth呈正相关，相关系数均有统计学意义。相同能量UVA照射后的不同皮肤反应性与b*、Depth呈正相关；相同能量UVB照射后的不同皮肤反应性与MI、EI、b*、Depth呈负相关，且相关系数有统计学意义。结论：肤色、皮肤黑素、皮肤厚度，能影响皮肤对紫外线的敏感性。肤色、皮肤黑素和血红素、皮肤厚度，能影响皮肤黑化反应和红斑反应的程度。
[关键词]光敏感性；皮肤色素；皮肤厚度；MED；MPPD
[中图分类号]R364.2+3 [文献标识码]A [文章编号]1008-6455(2012)04-0605-04
The effects of skin pigment and thickness on skin photosensitivity
XIA Mi-na1, WANG Xue-min2, LIU Yan-qun1, YUAN Chao2, ZOU Yin2, FAN Guo-biao2, WU Pei-lan2, LI Ning2
(1.Affiliated The Third Hospital of Xuzhou Medical College,Xuzhou 221002,Jiangsu,China; 2. Skin &Cosmetic Research Department,Shanghai Skin Disease Hospital)
Abstract： Objective To investigate the effects of skin pigment and thickness and the association of skin photosensitivity. Methods 31 subjects were exposed to two different Ultraviolet rays,before what Mexameter MX 16,Chromameter CR400 and skin B-ultrasonic were used to assess the text sites, then minimal erythema dose (MED)and minimal persistent pigment darkening dose (MPPD)were obtained. Results MPPD was negatively correlated with b*, MI, Depth,though MED was positively correlated with the three,and all of the correlation coefficients were statistically significant. Different skin photoreaction with the same UVA energy was affected by b*, Depth, and different skin photoreaction with the same UVB energy was affected by MI, EI, b*, Depth, and the correlation coefficients were statistically significant. Conclusion Skin UV sensitivity can be influenced by skin color, melanin and skin thickness. The tanning and erythematous degree after UV irradiation can be influenced by skin color, melanin，haemoglobin and skin thickness.
众所周知，紫外线照射可诱发多种光损害，如皮肤红斑、老化、光敏性疾病、异常的DNA合成、DNA损伤、免疫抑制以及皮肤肿瘤等。寻找一种结合皮肤特征预测紫外线损害的方法，是目前较为关注的话题，多数学者推荐的金标准是光试验，其中常用的指标为最小红斑量(minimal erythema dose,MED)和最小持续性黑化量(minimal persistent pigment darkening dose,MPPD)。用日光模拟仪测定皮肤的MED值和MPPD值可以比皮肤类型问卷调查更为准确、客观地反映受试者对紫外线的敏感性[1]。国内外众多学者发现皮肤光敏感性受到多种因素的影响：如遗传因素、模拟日光的波段、照射部位、地理环境因素[2-5]等 ......
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