乳房肥大患者外周血中雌激素表达水平研究(3)
目前有关外周血中雌激素水平与乳房肥大的统计学研究数据及病例较少。所以，为了使乳房肥大的病因学研究更好地服务于临床，本次收集了西京医院乳房肥大患者95例和正常体积乳房患者84例作为研究对象，为了确保所选患者均为腺性乳房肥大，排除一些由于过度肥胖所导致的脂肪性乳房肥大，对患者的体重指数及其他全身性疾病进行了严格筛选，排除由于肥胖原因造成的乳房体积的差异。女性患者的生理周期分为卵泡期、排卵期、黄体期及绝经期，由于处于绝经期的患者稀少，且绝经期妇女激素水平相对稳定，所以本次研究主要以卵泡期、排卵期和黄体期患者为主。3组处于不同生理周期的研究资料显示，乳房肥大组与正常体积乳房组患者外周血中17β-雌二醇比较，无明显升高，提示探索乳房肥大的病因应该从局部着手。大量的研究资料表明，乳房肥大可能是局部雌激素增多或乳房局部组织对雌激素的敏感性增强有关，所以进一步实验需要从局部去寻找与乳房肥大有关的雌激素水平及其受体的表达情况。
[参考文献]
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, 百拇医药
[2]Mundy LR，Homa K，Klassen AF，et al. Understanding the Health Burden of Macromastia： Normative Data for the BREAST-Q Reduction Module[J].Plast Reconstr Surg，2017，139(4)： 846e-853e.
[3]Karagüzel G，Bilen S，Kara?al N，et al.Virginal Breast Hypertrophy： Different Presentations of 2 Cases and the Role of Tamoxifen as an Adjuvant Therapy[J].J Pediatr Adolesc Gynecol，2016，29(5)：e71-e74.
[4]Zhao P，Soukup ST，Hegevoss J，et al.Anabolic effect of the traditional Chinese medicine compound tanshinone IIA on myotube hypertrophy is mediated by estrogen receptor[J].Planta Med，2015，81(7)：578-585.
, 百拇医药
[5]Zimman OA，Butto CD，Rostagno R，et al.Volumetric Mammogram Assessment： A Helpful Tool in the Treatment of Breast Asymmetries[J].Aesthetic Plast Surg，2017，41(6)：1261-1274.
[6]Sigurdson LJ，Kirkland SA.Breast volume determination in breast hypertrophy anaccurate method using two anthropomorphic measurements[J].Plast Reconstr Surg，2006，l18(2)：313-320.
[7]Dancey A，Khan M，Dawson J，et al.Gigantomastia-a classification and review of the literature[J].J Plast Reconstr Aesthet Surg，2008，61(5)：493-502.
, 百拇医药
[8]Beraldo FN，Veiga DF，Veiga-Filho J，et al.Sexual Function and Depression Outcomes Among Breast Hypertrophy Patients Undergoing Reduction Mammaplasty： A Randomized Controlled Trial[J].Ann Plast Surg，2016，76(4)：379-382.
[9]Mueller SO，Clark JA，Myers PH，et al.Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha[J].Endocrinology，2002，143(6)：2357-2365.
[10]Zhou M，Jin M，Wang L，et al.Pregnancy-associated gigantomastia recurrence and ectopic breast after reduction mammaplasty： A case report[J].Cancer Biomark，2017，20(2)：225-229.
, http://www.100md.com
[11]Portincasa A，Ciancio F，Cagiano L，et al.Septum-Enhanced Mammaplasty in Inferocentral Pedicled Breast Reduction for Macromastia and Gigantomastia Patients[J].Aesthetic Plast Surg，2017，41(5)：1037-1044.
[12]Zelazniewicz A，Pawlowski B.Breast size and asymmetry during pregnancy in dependence of a fetus's sex[J].Am J Hum Biol，2015，27(5)：690-696.
[13]Dickson RB，Huff KK，Spencer EM，et al.Induction of epidermal growth factor-related polypeptides by 17b-estradiol in MCF-7 human breast cancer cells[J].Endocrinology，1986，118(1)：138-142.
[14]Peker F，Yuksel F，Karagoz H，et al.Breast reconstruction using de-epithelialized dermal flap after vertical-pattern skin-sparing mastectomy in macromastia[J].ANZ J Surg，2015，85(1-2)：64-68.
[收稿日期]2018-01-28 [修回日期]2018-04-10
編辑/朱婉蓉, 百拇医药(王钠 马显杰 栗勇)
[参考文献]
[1]Tarallo M，Cigna E，Fino P，et al.sMacromastia surgical therapy[J].Ann Ital Chir，2011，82(3)：191-195.
, 百拇医药
[2]Mundy LR，Homa K，Klassen AF，et al. Understanding the Health Burden of Macromastia： Normative Data for the BREAST-Q Reduction Module[J].Plast Reconstr Surg，2017，139(4)： 846e-853e.
[3]Karagüzel G，Bilen S，Kara?al N，et al.Virginal Breast Hypertrophy： Different Presentations of 2 Cases and the Role of Tamoxifen as an Adjuvant Therapy[J].J Pediatr Adolesc Gynecol，2016，29(5)：e71-e74.
[4]Zhao P，Soukup ST，Hegevoss J，et al.Anabolic effect of the traditional Chinese medicine compound tanshinone IIA on myotube hypertrophy is mediated by estrogen receptor[J].Planta Med，2015，81(7)：578-585.
, 百拇医药
[5]Zimman OA，Butto CD，Rostagno R，et al.Volumetric Mammogram Assessment： A Helpful Tool in the Treatment of Breast Asymmetries[J].Aesthetic Plast Surg，2017，41(6)：1261-1274.
[6]Sigurdson LJ，Kirkland SA.Breast volume determination in breast hypertrophy anaccurate method using two anthropomorphic measurements[J].Plast Reconstr Surg，2006，l18(2)：313-320.
[7]Dancey A，Khan M，Dawson J，et al.Gigantomastia-a classification and review of the literature[J].J Plast Reconstr Aesthet Surg，2008，61(5)：493-502.
, 百拇医药
[8]Beraldo FN，Veiga DF，Veiga-Filho J，et al.Sexual Function and Depression Outcomes Among Breast Hypertrophy Patients Undergoing Reduction Mammaplasty： A Randomized Controlled Trial[J].Ann Plast Surg，2016，76(4)：379-382.
[9]Mueller SO，Clark JA，Myers PH，et al.Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha[J].Endocrinology，2002，143(6)：2357-2365.
[10]Zhou M，Jin M，Wang L，et al.Pregnancy-associated gigantomastia recurrence and ectopic breast after reduction mammaplasty： A case report[J].Cancer Biomark，2017，20(2)：225-229.
, http://www.100md.com
[11]Portincasa A，Ciancio F，Cagiano L，et al.Septum-Enhanced Mammaplasty in Inferocentral Pedicled Breast Reduction for Macromastia and Gigantomastia Patients[J].Aesthetic Plast Surg，2017，41(5)：1037-1044.
[12]Zelazniewicz A，Pawlowski B.Breast size and asymmetry during pregnancy in dependence of a fetus's sex[J].Am J Hum Biol，2015，27(5)：690-696.
[13]Dickson RB，Huff KK，Spencer EM，et al.Induction of epidermal growth factor-related polypeptides by 17b-estradiol in MCF-7 human breast cancer cells[J].Endocrinology，1986，118(1)：138-142.
[14]Peker F，Yuksel F，Karagoz H，et al.Breast reconstruction using de-epithelialized dermal flap after vertical-pattern skin-sparing mastectomy in macromastia[J].ANZ J Surg，2015，85(1-2)：64-68.
[收稿日期]2018-01-28 [修回日期]2018-04-10
編辑/朱婉蓉, 百拇医药(王钠 马显杰 栗勇)