乳房肥大患者外周血中雌激素表达水平研究(1)
[摘要]目的：研究乳房肥大患者外周血中雌激素表达水平，为乳房肥大患者病因学研究奠定基础，为腺性乳房肥大症的临床治疗提供相关实验依据。方法：将乳房肥大(95例)和正常体积乳房患者(84例)按照入院时处于月经周期的卵泡期、排卵期、黄体期进行分类，抽取患者入院当天外周血5ml，采用17β-雌二醇放射免疫药盒及SN-682放射免疫计数器测定外周血中17β-雌二醇表达水平，根据各指标OD值计算其浓度，结果采用放射免疫γ计数器及配套统计软件进行计数和数据处理。结果：在体重指数同一范围内，乳房肥大组与正常体积乳房组17β-雌二醇表达水平比较，差异无统计学意义(P>0.05)。结论：外周血中17β-雌二醇可能与乳房肥大的发生无关。
[关键词]乳房肥大症；雌激素；17β-雌二醇；外周血；体重指数
[中图分类号]R622 [文献标志码]A [文章编号]1008-6455(2018)05-0119-03
Study on Expression of Estrogen in Peripheral Blood of Patients with Mammary Hypertrophy
, 百拇医药
WANG Na，MA Xian-jie，LI Yong
(Department of Plastic Surgery，Xijing Hospital of the Military Medical University of the Air Force，Xi'an 710032，Shaanxi，China)
Abstract： Objective To study the expression of estrogen in peripheral blood of patients with mammary hypertrophy， and to lay a foundation for the study of etiology of mammary hypertrophy in the future， and to provide relevant experimental evidence for the clinical treatment of glandular mammary hypertrophy. Methods After admission， mammary hypertrophy (95 cases) and normal volume breast patients (84 cases) were classified according to the follicular phase， ovulation phase， and luteal phase during the menstrual cycle at the time of admission， and 5ml of peripheral blood was collected on the day of admission， using 17β-estradiol Radioimmunoassay kit and SN-682 radioimmunoassay counter were used to measure the expression level of 17β-estradiol in peripheral blood. The concentration was calculated according to the OD value of each index. The results were counted and processed by radioimmunoassay r counter and statistical software. Results There was no significant difference in the expression level of 17β-estradiol between hypertrophic breast and normal breast in the same range of body mass index(P>0.05). Conclusion 17β-estradiol in peripheral blood may not be related to the occurrence of mammary hypertrophy.
, http://www.100md.com
Key words： mammary hypertrophy； estrogen； 17β- estradiol； peripheral blood； body mass index
乳房肥大症，指女性乳房腺体及脂肪结缔组织过度增生导致的体积和重量增加[1-2]。乳房肥大多发生在青春期和妊娠后女性的一侧或两侧乳房，给年轻女性带来巨大的痛苦。雌激素(estrogen)是一种女性激素，由卵巢和胎盘产生，肾上腺皮质也产生少量雌激素。雌激素是生物体内许多生物学过程如生长、发育和复制的关键调节剂，在男性和女性体内都包括许多雌激素的靶器官如生殖道、乳房组织、骨骼、心血管和中枢神经系统[3-4]。乳房组织在体内作为一个性激素作用的重要靶器官，性激素在其生长、发育、成熟及功能方面发挥着重要作用。有关外周血中雌激素水平与乳房肥大是否有关系一直存在争议，课题组在乳房肥大患者和正常体积乳房患者的外周血中检测雌激素的水平，分析雌激素对乳房肥大的Z作用。由于前来就诊的患者处于绝经期的稀少，临床资料无统计学意义，本次只研究卵泡期、排卵期和黃体期3个时期各组患者外周血中17β-雌二醇水平的差异。
1 材料和方法
1.1 一般资料：实验组为2012年12月-2014年2月西京医院整形外科收治的因乳房肥大行乳房缩小整形术的患者95例(见图1)，其中卵泡期37例，排卵期32例，黄体期26例，均为女性，年龄14～51岁，平均29岁，平均体重指数22.25kg/m2，选择单侧乳房体积600ml以上，单侧乳房切除量均在300g以上。, http://www.100md.com(王钠 马显杰 栗勇)
[关键词]乳房肥大症；雌激素；17β-雌二醇；外周血；体重指数
[中图分类号]R622 [文献标志码]A [文章编号]1008-6455(2018)05-0119-03
Study on Expression of Estrogen in Peripheral Blood of Patients with Mammary Hypertrophy
, 百拇医药
WANG Na，MA Xian-jie，LI Yong
(Department of Plastic Surgery，Xijing Hospital of the Military Medical University of the Air Force，Xi'an 710032，Shaanxi，China)
Abstract： Objective To study the expression of estrogen in peripheral blood of patients with mammary hypertrophy， and to lay a foundation for the study of etiology of mammary hypertrophy in the future， and to provide relevant experimental evidence for the clinical treatment of glandular mammary hypertrophy. Methods After admission， mammary hypertrophy (95 cases) and normal volume breast patients (84 cases) were classified according to the follicular phase， ovulation phase， and luteal phase during the menstrual cycle at the time of admission， and 5ml of peripheral blood was collected on the day of admission， using 17β-estradiol Radioimmunoassay kit and SN-682 radioimmunoassay counter were used to measure the expression level of 17β-estradiol in peripheral blood. The concentration was calculated according to the OD value of each index. The results were counted and processed by radioimmunoassay r counter and statistical software. Results There was no significant difference in the expression level of 17β-estradiol between hypertrophic breast and normal breast in the same range of body mass index(P>0.05). Conclusion 17β-estradiol in peripheral blood may not be related to the occurrence of mammary hypertrophy.
, http://www.100md.com
Key words： mammary hypertrophy； estrogen； 17β- estradiol； peripheral blood； body mass index
乳房肥大症，指女性乳房腺体及脂肪结缔组织过度增生导致的体积和重量增加[1-2]。乳房肥大多发生在青春期和妊娠后女性的一侧或两侧乳房，给年轻女性带来巨大的痛苦。雌激素(estrogen)是一种女性激素，由卵巢和胎盘产生，肾上腺皮质也产生少量雌激素。雌激素是生物体内许多生物学过程如生长、发育和复制的关键调节剂，在男性和女性体内都包括许多雌激素的靶器官如生殖道、乳房组织、骨骼、心血管和中枢神经系统[3-4]。乳房组织在体内作为一个性激素作用的重要靶器官，性激素在其生长、发育、成熟及功能方面发挥着重要作用。有关外周血中雌激素水平与乳房肥大是否有关系一直存在争议，课题组在乳房肥大患者和正常体积乳房患者的外周血中检测雌激素的水平，分析雌激素对乳房肥大的Z作用。由于前来就诊的患者处于绝经期的稀少，临床资料无统计学意义，本次只研究卵泡期、排卵期和黃体期3个时期各组患者外周血中17β-雌二醇水平的差异。
1 材料和方法
1.1 一般资料：实验组为2012年12月-2014年2月西京医院整形外科收治的因乳房肥大行乳房缩小整形术的患者95例(见图1)，其中卵泡期37例，排卵期32例，黄体期26例，均为女性，年龄14～51岁，平均29岁，平均体重指数22.25kg/m2，选择单侧乳房体积600ml以上，单侧乳房切除量均在300g以上。, http://www.100md.com(王钠 马显杰 栗勇)