药物水光注射治疗黄褐斑对患者CK10、SOD及MDA表达水平的影响(1)
[摘要]目的：探讨药物水光注射治疗黄褐斑的疗效及对患者细胞角蛋白10(Cytokeratin 10，CK10)、超氧化物歧化酶(Superoxide dismutase，SOD)及丙二醛(Malondialdehyde，MDA)表达水平的影响。方法：选取笔者医院2016年5月-2017年5月收治的黄褐斑患者160例，随机分为传统组与药物组，每组80例。传统组采用传统穴位注射法治疗，药物组采用药物水光注射治疗。观察两组患者额部病损皮肤基底上层CK10表达程度、血清SOD、MDA水平并进行比较分析。结果：治疗后，药物组与传统组CK10表达程度明显减弱，药物组明显低于传统组，差异有统计学意义(P<0.05)。药物组与传统组SOD表达水平均显著升高，药物组明显高于传统组，差异有统计学意义(P<0.05)。药物组MDA水平明显低于治疗前，差异有统计学意义(P<0.05)；传统组MDA下降不明显，差异无统计学意义(P>0.05)。药物组总有效率为93.75%显著高于传统组的75.00%，差异有统计学意义(P<0.05)。结论：应用药物水光注射治疗黄褐斑，可降低病损皮肤基底上层CK10表达程度，改善血清SOD和MDA水平，疗效较好。
, 百拇医药
[关键词]水光注射；黄褐斑；细胞角蛋白10；超氧化物歧化酶；丙二醛
[中图分类号]R758.4+2 [文献标志码]A [文章编号]1008-6455(2018)07-0075-03
Abstract： Objective To investigate the effect of drugwater injection in the treatment of chloasma and the effect on the expression level of cytokeratin 10 (Cytokeratin 10， CK10)， superoxide dismutase (Superoxide dismutase， SOD) and malondialdehyde (Malondialdehyde， MDA) in patients. Methods 160 cases of Chloasma in our hospital from May 2016 to May 2017 were randomly divided into the traditional group and the drug group， 80 cases in each group. The traditional group used the traditional acupoint injection，and the drug group with drug water injection. The expression level of CK10，serum SOD and MDA in the upper basal layer of skin onforehead were compared between the drug group and the traditional group. Results After treatment， the expression level of CK10 in the drug group and the traditional group was significantly reduced， and the drug group was significantly lower than that in the traditional group， the differences were statistically significant(P<0.05). The expression levels of SOD in both the drug group and the traditional group were significantly increased， and the drug group was significantly higher than the traditional group(P<0.05). The level of MDA in the drug group was significantly lower than that before the treatment(P<0.05). There was no significant difference in MDA in the traditional group(P>0.05). The total effective rate in the drug group was 93.75%， which was significantly higher than that in the traditional group(75.00%，P<0.05). Conclusion The treatment of Chloasma with drug water injection can reduce the expression level of CK10 on the upper basal layer of skin lesions， improve the level of serum SOD and MDA， and improve the curative effect.
, 百拇医药
Key words： water injection； chloasma； CK10； SOD； MDA
黃褐斑主要表现为黄褐色及淡黄色斑片，主要在两颊和前颊部分，属于获得性色素沉着皮肤病[1]。化妆品使用不当、日晒、精神因素及避孕药等均是黄褐斑的主要诱因，多发于中青年女性。现临床主要通过内服药物、外用脱色剂及光化学手段对黄褐斑进行治疗，尽管治疗效果明显，但由于部分患者存在较强的局部刺激甚至灼伤皮肤，具有较明显的副作用甚至较高的复发率[2-3]。穴位注射以传统经络理论为基础，将已提纯药物注射至经络，对硬皮病、白塞氏综合征等国际疑难病均具有优良效果，与针灸治疗作用机理存在差别[4]。研究[5-6]提示药物水光注射通过特制注射工具吸起皮肤并利用负压将药物注射至靶向部位的疗法，具有并发症少，临床疗效高等特点，但关于黄褐斑的临床研究资料较少。故此，本研究探讨了药物水光注射和穴位注射治疗黄褐斑的疗效及对患者CK10、SOD及MDA表达水平的影响，现报道如下。, http://www.100md.com(李卉 胡霜红 王娟)
, 百拇医药
[关键词]水光注射；黄褐斑；细胞角蛋白10；超氧化物歧化酶；丙二醛
[中图分类号]R758.4+2 [文献标志码]A [文章编号]1008-6455(2018)07-0075-03
Abstract： Objective To investigate the effect of drugwater injection in the treatment of chloasma and the effect on the expression level of cytokeratin 10 (Cytokeratin 10， CK10)， superoxide dismutase (Superoxide dismutase， SOD) and malondialdehyde (Malondialdehyde， MDA) in patients. Methods 160 cases of Chloasma in our hospital from May 2016 to May 2017 were randomly divided into the traditional group and the drug group， 80 cases in each group. The traditional group used the traditional acupoint injection，and the drug group with drug water injection. The expression level of CK10，serum SOD and MDA in the upper basal layer of skin onforehead were compared between the drug group and the traditional group. Results After treatment， the expression level of CK10 in the drug group and the traditional group was significantly reduced， and the drug group was significantly lower than that in the traditional group， the differences were statistically significant(P<0.05). The expression levels of SOD in both the drug group and the traditional group were significantly increased， and the drug group was significantly higher than the traditional group(P<0.05). The level of MDA in the drug group was significantly lower than that before the treatment(P<0.05). There was no significant difference in MDA in the traditional group(P>0.05). The total effective rate in the drug group was 93.75%， which was significantly higher than that in the traditional group(75.00%，P<0.05). Conclusion The treatment of Chloasma with drug water injection can reduce the expression level of CK10 on the upper basal layer of skin lesions， improve the level of serum SOD and MDA， and improve the curative effect.
, 百拇医药
Key words： water injection； chloasma； CK10； SOD； MDA
黃褐斑主要表现为黄褐色及淡黄色斑片，主要在两颊和前颊部分，属于获得性色素沉着皮肤病[1]。化妆品使用不当、日晒、精神因素及避孕药等均是黄褐斑的主要诱因，多发于中青年女性。现临床主要通过内服药物、外用脱色剂及光化学手段对黄褐斑进行治疗，尽管治疗效果明显，但由于部分患者存在较强的局部刺激甚至灼伤皮肤，具有较明显的副作用甚至较高的复发率[2-3]。穴位注射以传统经络理论为基础，将已提纯药物注射至经络，对硬皮病、白塞氏综合征等国际疑难病均具有优良效果，与针灸治疗作用机理存在差别[4]。研究[5-6]提示药物水光注射通过特制注射工具吸起皮肤并利用负压将药物注射至靶向部位的疗法，具有并发症少，临床疗效高等特点，但关于黄褐斑的临床研究资料较少。故此，本研究探讨了药物水光注射和穴位注射治疗黄褐斑的疗效及对患者CK10、SOD及MDA表达水平的影响，现报道如下。, http://www.100md.com(李卉 胡霜红 王娟)
参见：首页 > 医疗版 > 疾病专题 > 皮肤科 > 色素障碍性皮肤病(色素沉着) > 黄褐斑(肝斑)