“功能医学”与抗衰老(4)
[13]Hoppe U，Bergemann J，Diembeck W，et al.Coenzyme Q10： acutaneous antioxidant and energizer[J].Biofactors，1999，9(1)：371-375.
[14]Weyer G，Babej-Dolle RM，Hadler D，et al.A controlled study of 2 doses of idebenone in the treatment of Alzheimer’s disease[J].
Neuropsychobiology，1997，36(1)：73-82.
[15]Ziegler D，Ametov A，Barinov A，et al.Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy： the SYDNEY 2 trial[J].Diabetes Care，2006，29(11)：2365-2370.
, 百拇医药
[16]Haak E，Usadel KH，Kusterer K，et al.Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy[J].Exp Clin Endocrinol Diabetes，2000，108(3)：168-174.
[17]Vaiserman AM，Lushchak OV，Koliada AK.Anti-aging pharmacology： Promises and pitfalls[J].Ageing Res Rev，2016，31：9-35.
[18]Anisimov VN，Egorov MV，Krasilshchikova MS，et al.Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents[J].Aging (Albany NY)，2011，3(11)：1110-1119.
, 百拇医药
[19]Pullerits R，Bokarewa M，Dahlberg L，et al.Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control[J].Arthritis Res Ther，2005，7(4)：R817-R824.
[20]Pullerits R，Bokarewa M，Dahlberg L，et al.Advanced glycation end products are increased in the skin and blood of patients with severe psoriasis[J].Acta Derm Venereol，2017，97(7)：782-787.
[21]Kumar S，Lombard DB.Finding ponce de Leon's pill： challenges in screening for anti-aging molecules[J].F1000Res，2016，5(1)：406-416.
, http://www.100md.com
[22]Zheng Z，Cheng C，Dong R，et al.Advanced glycation end products upregulate angiopoietin-like protein 4 expression by activating the renin-angiotensin system in endothelial cells[J].Biomed Rep，2015，3(4)：578-582.
[23]Stirban A，Negrean M，Stratmann B，et al.Benfotiamineprevents macro-and microvascular endothelial dysfunction and oxidativestress following a meal rich in advanced glycation end products in individualswith type 2 diabetes[J].Diab Care，2006，29(1)：2064-2071.
, http://www.100md.com
[24]Little WC，Zile MR，Kitzman DW，et al.The effectof alagebrium chloride (ALT-711)， a novel glucose cross-link breaker， in thetreatment of elderly patients with diastolic heart failure[J].J Card Fail，2005，11(1)：191-195.
[25]Thallas-Bonke V，Lindschau C，Rizkalla B，et al.Attenuation of extracellular matrixaccumulation in diabetic nephropathy by the advanced glycation end productcross-link breaker ALT-711 via a protein kinase C--dependent pathway[J].Diabetes，2004，53(1)：2921-2930.
, 百拇医药
[26]Diamanti-Kandarakis E，Katsikis I，Piperi C，et al.Effect of long-term orlistat treatment on serum levels of advanced glycation end-products in women with polycystic ovary syndrome[J].Clin Endocrinol
(Oxf)，2007，66(1)：103-109.
[收稿日期]2018-04-10 [修回日期]2018-07-27
編辑/朱婉蓉, http://www.100md.com(闻莉 潘洁 胡学庆 包祺 马奇 赵启明)
[14]Weyer G，Babej-Dolle RM，Hadler D，et al.A controlled study of 2 doses of idebenone in the treatment of Alzheimer’s disease[J].
Neuropsychobiology，1997，36(1)：73-82.
[15]Ziegler D，Ametov A，Barinov A，et al.Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy： the SYDNEY 2 trial[J].Diabetes Care，2006，29(11)：2365-2370.
, 百拇医药
[16]Haak E，Usadel KH，Kusterer K，et al.Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy[J].Exp Clin Endocrinol Diabetes，2000，108(3)：168-174.
[17]Vaiserman AM，Lushchak OV，Koliada AK.Anti-aging pharmacology： Promises and pitfalls[J].Ageing Res Rev，2016，31：9-35.
[18]Anisimov VN，Egorov MV，Krasilshchikova MS，et al.Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents[J].Aging (Albany NY)，2011，3(11)：1110-1119.
, 百拇医药
[19]Pullerits R，Bokarewa M，Dahlberg L，et al.Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control[J].Arthritis Res Ther，2005，7(4)：R817-R824.
[20]Pullerits R，Bokarewa M，Dahlberg L，et al.Advanced glycation end products are increased in the skin and blood of patients with severe psoriasis[J].Acta Derm Venereol，2017，97(7)：782-787.
[21]Kumar S，Lombard DB.Finding ponce de Leon's pill： challenges in screening for anti-aging molecules[J].F1000Res，2016，5(1)：406-416.
, http://www.100md.com
[22]Zheng Z，Cheng C，Dong R，et al.Advanced glycation end products upregulate angiopoietin-like protein 4 expression by activating the renin-angiotensin system in endothelial cells[J].Biomed Rep，2015，3(4)：578-582.
[23]Stirban A，Negrean M，Stratmann B，et al.Benfotiamineprevents macro-and microvascular endothelial dysfunction and oxidativestress following a meal rich in advanced glycation end products in individualswith type 2 diabetes[J].Diab Care，2006，29(1)：2064-2071.
, http://www.100md.com
[24]Little WC，Zile MR，Kitzman DW，et al.The effectof alagebrium chloride (ALT-711)， a novel glucose cross-link breaker， in thetreatment of elderly patients with diastolic heart failure[J].J Card Fail，2005，11(1)：191-195.
[25]Thallas-Bonke V，Lindschau C，Rizkalla B，et al.Attenuation of extracellular matrixaccumulation in diabetic nephropathy by the advanced glycation end productcross-link breaker ALT-711 via a protein kinase C--dependent pathway[J].Diabetes，2004，53(1)：2921-2930.
, 百拇医药
[26]Diamanti-Kandarakis E，Katsikis I，Piperi C，et al.Effect of long-term orlistat treatment on serum levels of advanced glycation end-products in women with polycystic ovary syndrome[J].Clin Endocrinol
(Oxf)，2007，66(1)：103-109.
[收稿日期]2018-04-10 [修回日期]2018-07-27
編辑/朱婉蓉, http://www.100md.com(闻莉 潘洁 胡学庆 包祺 马奇 赵启明)