超分子水杨酸外用治疗轻、中度痤疮疗效观察(1)
[摘要]目的：探讨超分子水杨酸外用治疗轻、中度痤疮的临床疗效。方法：采用随机对照的方法将140例轻、中度痤疮患者分为两组。对照组：70例，采用阿达帕林凝胶外用治疗；治疗组：70例，采用30%超分子水杨酸和2%超分子水杨酸凝露治疗。治疗12周后，在1个月和3个月分别进行随访、观察，记录皮损消退情况和不良反应。结果：治疗结束后1个月随访，治疗组总有效率50.72%，对照组总有效率28.36%；3个月时随访，治疗组总有效率91.30%，对照组总有效率46.27%，两组有显著性差异，具有统计学意义(P<0.05)。治疗组不良反应发生率为5.80%，对照组为59.70%，两组均未发生严重不良反应。结论：超分子水杨酸外用治疗轻中度痤疮安全、有效，不良反应轻微，患者依从性好，可临床推广应用。
[关键词]超分子化学；水杨酸；痤疮；化学换肤术
[中图分类号]R758.73+3 [文献标志码]A [文章编号]1008-6455(2018)09-0031-03
, http://www.100md.com
Clinical Investigation of Supramolecular Salicylic Acid in the Treatment of Mild to Middle Acne Vulgaris
TANG Li， YIN Rui，LUO Na，XIAO Yan，LIU Yue-ling，XIA Ai-ai，LI Chao-hui，YANG Li
(Department of Dermatology， Southwest Hospital， Army Military Medical University， Chongqing 400038，China)
Abstract： Objective To investigate the clinical efficacy and safety of supramolecular salicylic acid to treat mild to moderate acne vulgaris. Methods 140 cases of mild to moderate facial acne vulgaris patients were randomly divided into two groups： 70 cases in the experimental group treated by supramolecular salicylic acid and 70 cases in the control group (0.1% adapalene gel). Both of two groups accepted the treatment for 12 weeks.Two independent investigators evaluated outcomes and recorded side-effects at 1 and 3 months post-treatment. Results The effective rate of the experimental group was 50.72% and 91.3% respectively at 1 and 3 months post-treatment. Meanwhile， the control group was 28.36% and 46.27% respectively. There was significant difference between the two groups (P<0. 05). The incidence of adverse reactions of the treatment group was 5.8%， the control group was 59.70%. There were no obvious side-effects in both groups. Conclusion The combination treatment of acne vulgaris with glycolic acid is benefit for moderate to severe acne vulgaris. The side-effects is less and worth to apply in clinics.
, 百拇医药
Key words： supramolecular chemistry； salicylic acid； acne；chemical peeling
痤疮是皮肤科最常见的一种慢性毛囊皮脂腺的炎症性疾病，其发病机制复杂，主要好发于青少年，对青少年的心理和社交影响很大。2016年6 -2017年7月，笔者科室采用超分子水杨酸外用治疗轻、中度痤疮患者，取得较好的临床疗效，现将结果报道如下。
1 临床资料
1.1 一般资料：140例患者均来自于笔者医院皮肤科门诊，确诊为痤疮。运用改良Pillsbury分级法[1]，分级属于Ⅰ～Ⅱ级，其中男56例，女84例，年龄18～43岁，平均年龄26.2岁。按患者在门诊的就诊顺序将其随机分成两组。治疗组：70例，其中男26例，女44例，年龄18～38岁，平均年龄25.92岁，Ⅰ级32例，Ⅱ级38例；对照组：70例，其中男30例，女40例，年龄19～43岁，平均26.48岁，Ⅰ级34例，Ⅱ级36例。两组患者性别、年龄及皮疹分度均没有可比性(P>0.05)。
1.2 排除标准：①近半年来有口服过维A酸类药物者；②近4周服用光敏性药物者；③妊娠及哺乳期女性；④面部有伤口、活动性单纯疱疹、疣等皮肤病者；⑤敏感性皮肤；⑥不能遵医嘱配合治疗者。
2 方法
2.1 材料和药物：采用浓度分别为30%的新型超分子水杨酸，2%水杨酸凝露(商品名：博乐达，上海瑞志医药科技有限公司)；0.1%阿达帕林凝胶(商品名：达芙文，法国高德美制藥公司)。, 百拇医药(唐莉 尹锐 罗娜 肖艳 刘悦玲 夏爱爱 李朝惠 杨利)
[关键词]超分子化学；水杨酸；痤疮；化学换肤术
[中图分类号]R758.73+3 [文献标志码]A [文章编号]1008-6455(2018)09-0031-03
, http://www.100md.com
Clinical Investigation of Supramolecular Salicylic Acid in the Treatment of Mild to Middle Acne Vulgaris
TANG Li， YIN Rui，LUO Na，XIAO Yan，LIU Yue-ling，XIA Ai-ai，LI Chao-hui，YANG Li
(Department of Dermatology， Southwest Hospital， Army Military Medical University， Chongqing 400038，China)
Abstract： Objective To investigate the clinical efficacy and safety of supramolecular salicylic acid to treat mild to moderate acne vulgaris. Methods 140 cases of mild to moderate facial acne vulgaris patients were randomly divided into two groups： 70 cases in the experimental group treated by supramolecular salicylic acid and 70 cases in the control group (0.1% adapalene gel). Both of two groups accepted the treatment for 12 weeks.Two independent investigators evaluated outcomes and recorded side-effects at 1 and 3 months post-treatment. Results The effective rate of the experimental group was 50.72% and 91.3% respectively at 1 and 3 months post-treatment. Meanwhile， the control group was 28.36% and 46.27% respectively. There was significant difference between the two groups (P<0. 05). The incidence of adverse reactions of the treatment group was 5.8%， the control group was 59.70%. There were no obvious side-effects in both groups. Conclusion The combination treatment of acne vulgaris with glycolic acid is benefit for moderate to severe acne vulgaris. The side-effects is less and worth to apply in clinics.
, 百拇医药
Key words： supramolecular chemistry； salicylic acid； acne；chemical peeling
痤疮是皮肤科最常见的一种慢性毛囊皮脂腺的炎症性疾病，其发病机制复杂，主要好发于青少年，对青少年的心理和社交影响很大。2016年6 -2017年7月，笔者科室采用超分子水杨酸外用治疗轻、中度痤疮患者，取得较好的临床疗效，现将结果报道如下。
1 临床资料
1.1 一般资料：140例患者均来自于笔者医院皮肤科门诊，确诊为痤疮。运用改良Pillsbury分级法[1]，分级属于Ⅰ～Ⅱ级，其中男56例，女84例，年龄18～43岁，平均年龄26.2岁。按患者在门诊的就诊顺序将其随机分成两组。治疗组：70例，其中男26例，女44例，年龄18～38岁，平均年龄25.92岁，Ⅰ级32例，Ⅱ级38例；对照组：70例，其中男30例，女40例，年龄19～43岁，平均26.48岁，Ⅰ级34例，Ⅱ级36例。两组患者性别、年龄及皮疹分度均没有可比性(P>0.05)。
1.2 排除标准：①近半年来有口服过维A酸类药物者；②近4周服用光敏性药物者；③妊娠及哺乳期女性；④面部有伤口、活动性单纯疱疹、疣等皮肤病者；⑤敏感性皮肤；⑥不能遵医嘱配合治疗者。
2 方法
2.1 材料和药物：采用浓度分别为30%的新型超分子水杨酸，2%水杨酸凝露(商品名：博乐达，上海瑞志医药科技有限公司)；0.1%阿达帕林凝胶(商品名：达芙文，法国高德美制藥公司)。, 百拇医药(唐莉 尹锐 罗娜 肖艳 刘悦玲 夏爱爱 李朝惠 杨利)
参见：首页 > 医疗版 > 疾病专题 > 皮肤科 > 皮肤附属器官疾病 > 痤疮(青春痘)