间充质干细胞来源外泌体在创面修复中的作用及其机制研究进展(7)
[32]赵贵芳.脐带间充质干细胞及其来源外泌体修复皮肤损伤的机制研究[D].吉林：吉林大学，2016.
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[34]Hughes CC.Endothelial-stromal interactions in angiogenesis[J].Curr Opin Hematol，2008，15(3)：204-209.
[35]Zhang B，Wu X，Zhang X，et al.Human umbilical cord mesenchymal stem cell exosomes enhance angiogenesis through the Wnt4/beta-catenin pathway[J].Stem Cells Transl Med，2015，4(5)：513-522.
, http://www.100md.com
[36]Zhang L，Wrana JL.The emerging role of exosomes in wnt secretion and transport[J].Curr Opin Genet Dev，2014，27(2)：14-19.
[37]Dostert G，Willemin A S，Jouan-Hureaux V，et al.Evaluation of the pro-angiogenic effect of nanoscale extracellular vesicles derived from human umbilical cord mesenchymal stem cells[J].Biomed Mater Eng，2017，28(s1)：S75-S79.
[38]Zhang B，Wang M，Gong A，et al.HucMSC-exosome mediated-wnt4 signaling is required for cutaneous wound healing[J].Stem Cells，2015，33(7)：2158-2168.
, 百拇医药
[39]Gong M， Yu B，Wang J，et al.Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis[J].Oncotarget，2017，8(28)：45200-45212.
[40]Anderson JD，Johansson HJ，Graham CS，et al.Comprehensive proteomic analysis of mesenchymal stem cell exosomes reveals modulation of angiogenesis via nuclear factor-kappab signaling[J].Stem Cells，2016，34(3)：601-613.
[41]Teng X，Chen L，Chen W，et al.Mesenchymal stem cell-derived exosomes improve the microenvironment of infarcted myocardium contributing to angiogenesis and anti-inflammation[J].Cell Physiol Biochem，2015，37(6)：2415-2424.
, 百拇医药
[42]Tan CY， Lai RC，Wong W，et al.Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models[J].Stem Cell Res Ther，2014，5(3)：76.
[43]Liang X，Zhang L，Wang S，et al.Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a[J].J Cell Sci，2016，129(11)：2182-2189.
[44]Lopatina T，Bruno S，Tetta C，et al.Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential[J].Cell Commun Signal，2014，12：26.
, 百拇医药
[45]Luo Q，Guo D，Liu G，et al.Exosomes from MiR-126-Overexpressing adscs are therapeutic in relieving acute myocardial ischaemic injury[J].Cell Physiol Biochem，2017，44(6)：2105-2116.
[46]Liu R，Shen H，Ma J，et al.Extracellular vesicles derived from adipose mesenchymal stem cells regulate the phenotype of smooth muscle cells to limit intimal hyperplasia[J].Cardiovasc Drugs Ther，2016，30(2)：111-118.
[47]Eirin A，Zhu XY， Puranik AS，et al.Integrated transcriptomic and proteomic analysis of the molecular cargo of extracellular vesicles derived from porcine adipose tissue-derived mesenchymal stem cells[J].PLoS One，2017，12(3)：e174303.
, 百拇医药
[48]Dai M，Yu M，Zhang Y，et al.Exosome-like vesicles derived from adipose tissue provide biochemical cues for adipose tissue regeneration[J].Tissue Eng Part A，2017，23(21-22)：1221-1230.
[49]Zhang Y，Yu M，Dai M，et al.miR-450a-5p within rat adipose tissue exosome-like vesicles promotes adipogenic differentiation by targeting WISP2[J].J Cell Sci，2017，130(6)：1158-1168.
[50]Watson DC，Yung BC，Bergamaschi C，et al.Scalable，cGMP-compatible purification of extracellular vesicles carrying bioactive human heterodimeric IL-15/lactadherin complexes[J].J Extracell Vesicles，2018，7(1)：1442088.
[收稿日期]2018-03-12 [修回日期]2018-06-28
編辑/李阳利, 百拇医药(何强 张培华)
[33]Liekens S，De Clercq E，Neyts J.Angiogenesis：regulators and clinical applications[J].Biochem Pharmacol，2001，61(3)：253-270.
[34]Hughes CC.Endothelial-stromal interactions in angiogenesis[J].Curr Opin Hematol，2008，15(3)：204-209.
[35]Zhang B，Wu X，Zhang X，et al.Human umbilical cord mesenchymal stem cell exosomes enhance angiogenesis through the Wnt4/beta-catenin pathway[J].Stem Cells Transl Med，2015，4(5)：513-522.
, http://www.100md.com
[36]Zhang L，Wrana JL.The emerging role of exosomes in wnt secretion and transport[J].Curr Opin Genet Dev，2014，27(2)：14-19.
[37]Dostert G，Willemin A S，Jouan-Hureaux V，et al.Evaluation of the pro-angiogenic effect of nanoscale extracellular vesicles derived from human umbilical cord mesenchymal stem cells[J].Biomed Mater Eng，2017，28(s1)：S75-S79.
[38]Zhang B，Wang M，Gong A，et al.HucMSC-exosome mediated-wnt4 signaling is required for cutaneous wound healing[J].Stem Cells，2015，33(7)：2158-2168.
, 百拇医药
[39]Gong M， Yu B，Wang J，et al.Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis[J].Oncotarget，2017，8(28)：45200-45212.
[40]Anderson JD，Johansson HJ，Graham CS，et al.Comprehensive proteomic analysis of mesenchymal stem cell exosomes reveals modulation of angiogenesis via nuclear factor-kappab signaling[J].Stem Cells，2016，34(3)：601-613.
[41]Teng X，Chen L，Chen W，et al.Mesenchymal stem cell-derived exosomes improve the microenvironment of infarcted myocardium contributing to angiogenesis and anti-inflammation[J].Cell Physiol Biochem，2015，37(6)：2415-2424.
, 百拇医药
[42]Tan CY， Lai RC，Wong W，et al.Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models[J].Stem Cell Res Ther，2014，5(3)：76.
[43]Liang X，Zhang L，Wang S，et al.Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a[J].J Cell Sci，2016，129(11)：2182-2189.
[44]Lopatina T，Bruno S，Tetta C，et al.Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential[J].Cell Commun Signal，2014，12：26.
, 百拇医药
[45]Luo Q，Guo D，Liu G，et al.Exosomes from MiR-126-Overexpressing adscs are therapeutic in relieving acute myocardial ischaemic injury[J].Cell Physiol Biochem，2017，44(6)：2105-2116.
[46]Liu R，Shen H，Ma J，et al.Extracellular vesicles derived from adipose mesenchymal stem cells regulate the phenotype of smooth muscle cells to limit intimal hyperplasia[J].Cardiovasc Drugs Ther，2016，30(2)：111-118.
[47]Eirin A，Zhu XY， Puranik AS，et al.Integrated transcriptomic and proteomic analysis of the molecular cargo of extracellular vesicles derived from porcine adipose tissue-derived mesenchymal stem cells[J].PLoS One，2017，12(3)：e174303.
, 百拇医药
[48]Dai M，Yu M，Zhang Y，et al.Exosome-like vesicles derived from adipose tissue provide biochemical cues for adipose tissue regeneration[J].Tissue Eng Part A，2017，23(21-22)：1221-1230.
[49]Zhang Y，Yu M，Dai M，et al.miR-450a-5p within rat adipose tissue exosome-like vesicles promotes adipogenic differentiation by targeting WISP2[J].J Cell Sci，2017，130(6)：1158-1168.
[50]Watson DC，Yung BC，Bergamaschi C，et al.Scalable，cGMP-compatible purification of extracellular vesicles carrying bioactive human heterodimeric IL-15/lactadherin complexes[J].J Extracell Vesicles，2018，7(1)：1442088.
[收稿日期]2018-03-12 [修回日期]2018-06-28
編辑/李阳利, 百拇医药(何强 张培华)
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