美学区种植同期引导骨再生采用不同愈合方式的评价研究(3)
综上，在应用GBR技术的同时，穿龈式与埋入式可以获得相同的种植成功与临床效果，但需要对患者谨慎的术前评估及手术操作的熟练把控。由于该研究目前观察期较短，样本量有限，尚须进一步随访观察及更大样本量的纳入研究。
[参考文献]
[1]Stefanini M，Felice P，Mazzotti C，et al.Transmucosal implant placement with submarginal connective tissue graft in area of shallow buccal bone dehiscence： A three-year follow-up case series[J].Int J Periodontics Restorative Dent，2016，36(5)：621-630.
[2]Ting M，Tenaglia MS，Jones GH，et al.Surgical and patient factors affecting marginal bone levels around dental implants： a comprehensive overview of systematic reviews[J].Implant Dent，2017，26(2)：303-315.
, 百拇医药
[3]王峻.引导骨再生膜技术在种植义齿美学修复中的临床分析[J].中国美容医学，2018，27(5)：77-80.
[4]Lorenz J，Lerner H，Sader RA，et al.Investigation of peri-implant tissue conditions and peri-implant tissue stability in implants placed with simultaneous augmentation procedure： a 3-year retrospective follow-up analysis of a newly developed bone level implant system[J].Int J Implant Dent，2017，3(1)：41.
[5]潘夏薇，赖颖真，陈江.种植体穿龈部分氮化钛纳米涂层对牙龈成纤维细胞粘附和增殖的影响[J].口腔医学研究，2017，2(33)：154-157.
, 百拇医药
[6]赵平，史俊.种植体埋入式愈合与非埋入式愈合的临床疗效比较[J].上海口腔医学，2010，19(6)：594-597.
[7]Brunski JB. Biomechanical factors affecting the bone-dental implant interface[J]. Clin Mater，1992，10(3)：153-201.
[8]Schroeder A，Pohler O，Sutter F.Tissue reaction to an implant of a titanium hollow cylinder with a titanium surface spray layer[J].SSO Schweiz Monatsschr Zahnheilkd，1976，86(7)：713-727.
[9]Troiano G，Lo RL，Canullo L，et al.Early and late implant failure of submerged versus non-submerged implant healing： a systematic review， meta-analysis and trial sequential analysis[J].J Clin Periodontol，2018，45(5)：613-623.
, http://www.100md.com
[10]Torkzaban P，Arabi SR，Roshanaei G，et al.A comparative study of clinical parameters in submerged and non submerged implants[J].J Clin Diagn Res，2015，9(3)：26-29.
[11]Kohal RJ，Trejo PM，Wirsching C，et al.Comparison of bioabsorbable and bioinert membranes for guided bone regeneration around non-submerged implants. An experimental study in the mongrel dog[J].Clin Oral Implants Res，1999，10(3)： 226-237.
[12]H?mmerle CH，Jung RE，Sanz M，et al.Submerged and transmucosal healing yield the same clinical outcomes with two-piece implants in the anterior maxilla and mandible： interim 1-year results of a randomized，controlled clinical trial[J].Clin Oral Implants Res，2012，23(2)：211-219.
, http://www.100md.com
[13]CordaroL，TorselloF，ChenS，et al.Implant-supported single tooth restoration in the aesthetic zone： transmucosal and submerged healing provide similar outcome when simultaneous bone augmentation is needed[J].Clin Oral Implants Res，2013，24(10)：1130-1136.
[14]Albrektsson T，Zarb G，Worthington P，et al.The long-term efficacy of currently used dental implants： a review and proposed criteria of success [J].Int J Oral Maxillofac Implants，1986，1(1)：11-25.
, 百拇医药
[15]Weber HP，Crohin CC，Fiorellini JP.A 5-year prospective clinical and radiographic study of non-submerged dental implants[J].Clin Oral Implants Res，2000，11(2)：144-153.
[16]Sanz M，Ivanoff CJ，Weingart D，et al.Clinical and radiologic outcomes after submerged and transmucosal implant placement with two-piece implants in the anterior maxilla and mandible：3-year results of a randomized controlled clinical trial[J].Clin Implant Dent Relat Res，2015，17(2)：234-246.
[收稿日期]2018-08-07 [修回日期]2018-09-29
編辑/李阳利, http://www.100md.com(封伟 王楠 耿进友 孙园园)
[参考文献]
[1]Stefanini M，Felice P，Mazzotti C，et al.Transmucosal implant placement with submarginal connective tissue graft in area of shallow buccal bone dehiscence： A three-year follow-up case series[J].Int J Periodontics Restorative Dent，2016，36(5)：621-630.
[2]Ting M，Tenaglia MS，Jones GH，et al.Surgical and patient factors affecting marginal bone levels around dental implants： a comprehensive overview of systematic reviews[J].Implant Dent，2017，26(2)：303-315.
, 百拇医药
[3]王峻.引导骨再生膜技术在种植义齿美学修复中的临床分析[J].中国美容医学，2018，27(5)：77-80.
[4]Lorenz J，Lerner H，Sader RA，et al.Investigation of peri-implant tissue conditions and peri-implant tissue stability in implants placed with simultaneous augmentation procedure： a 3-year retrospective follow-up analysis of a newly developed bone level implant system[J].Int J Implant Dent，2017，3(1)：41.
[5]潘夏薇，赖颖真，陈江.种植体穿龈部分氮化钛纳米涂层对牙龈成纤维细胞粘附和增殖的影响[J].口腔医学研究，2017，2(33)：154-157.
, 百拇医药
[6]赵平，史俊.种植体埋入式愈合与非埋入式愈合的临床疗效比较[J].上海口腔医学，2010，19(6)：594-597.
[7]Brunski JB. Biomechanical factors affecting the bone-dental implant interface[J]. Clin Mater，1992，10(3)：153-201.
[8]Schroeder A，Pohler O，Sutter F.Tissue reaction to an implant of a titanium hollow cylinder with a titanium surface spray layer[J].SSO Schweiz Monatsschr Zahnheilkd，1976，86(7)：713-727.
[9]Troiano G，Lo RL，Canullo L，et al.Early and late implant failure of submerged versus non-submerged implant healing： a systematic review， meta-analysis and trial sequential analysis[J].J Clin Periodontol，2018，45(5)：613-623.
, http://www.100md.com
[10]Torkzaban P，Arabi SR，Roshanaei G，et al.A comparative study of clinical parameters in submerged and non submerged implants[J].J Clin Diagn Res，2015，9(3)：26-29.
[11]Kohal RJ，Trejo PM，Wirsching C，et al.Comparison of bioabsorbable and bioinert membranes for guided bone regeneration around non-submerged implants. An experimental study in the mongrel dog[J].Clin Oral Implants Res，1999，10(3)： 226-237.
[12]H?mmerle CH，Jung RE，Sanz M，et al.Submerged and transmucosal healing yield the same clinical outcomes with two-piece implants in the anterior maxilla and mandible： interim 1-year results of a randomized，controlled clinical trial[J].Clin Oral Implants Res，2012，23(2)：211-219.
, http://www.100md.com
[13]CordaroL，TorselloF，ChenS，et al.Implant-supported single tooth restoration in the aesthetic zone： transmucosal and submerged healing provide similar outcome when simultaneous bone augmentation is needed[J].Clin Oral Implants Res，2013，24(10)：1130-1136.
[14]Albrektsson T，Zarb G，Worthington P，et al.The long-term efficacy of currently used dental implants： a review and proposed criteria of success [J].Int J Oral Maxillofac Implants，1986，1(1)：11-25.
, 百拇医药
[15]Weber HP，Crohin CC，Fiorellini JP.A 5-year prospective clinical and radiographic study of non-submerged dental implants[J].Clin Oral Implants Res，2000，11(2)：144-153.
[16]Sanz M，Ivanoff CJ，Weingart D，et al.Clinical and radiologic outcomes after submerged and transmucosal implant placement with two-piece implants in the anterior maxilla and mandible：3-year results of a randomized controlled clinical trial[J].Clin Implant Dent Relat Res，2015，17(2)：234-246.
[收稿日期]2018-08-07 [修回日期]2018-09-29
編辑/李阳利, http://www.100md.com(封伟 王楠 耿进友 孙园园)
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