去铁胺促进血管内皮祖细胞靶向归巢和血管化的实验研究(5)
brain[J].Eur J Neurosci，1999，11(12)：4159-4170.
[5]Gray MJ，Zhang J，Ellis LM，et al.HIF-1alpha，STAT3，CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas[J].Oncogene，2005，24(19)：3110-3120.
[6]Ratajczak MZ，Zuba-Surma E，Kucia M.The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis，regeneration and tumorigenesis[J].Leukemia，2006，20(11)：1915-1924.
, 百拇医药
[7]Hou Z，Nie C，Si Z，et al.Deferoxamine enhances neovascularization and accelerates wound healing in diabetic rats via the accumulation of hypoxia-inducible factor-1α[J].Diabetes Res Clin Pract，2013，101(1)：62-71.
[8]Ikeda Y，Tajima S，Yoshida S，et al.Deferoxamine promotes angiogenesis via the activation of vascular endothelial cell function[J].
Atherosclerosis，2011，215(2)：339-347.
[9]Chekanov VS，Zargarian M，Baibekov I，et al.Deferoxamine-fibrin accelerates angiogenesis in a rabbit model of peripheral ischemia[J].Vasc Med，2003，8(3)：157-162.
, 百拇医药
[10]Niiyama H，Huang NF，Rollins MD，et al.Murine model of hindlimb ischemia[J].J Vis Exp，2009，23(23)：e1035.
[11]Krenning G，van Luyn MJ，Harmsen MC.Endothelial progenitor cell-based neovascularization：implications for therapy[J].Trends Mol Med，2009，15(4)：180-189.
[12]Botta R，Gao E，Stassi G，et al.Heart infarct in NOD-SCID mice：therapeutic vasculogenesis by transplantation of human CD34+ cells and low dose CD34+ KDR+ cells[J].FASEB J，2004，18(12)：1392-1394.
, 百拇医药
[13]邓蓉蓉，谢伊旻，谢林.间充质干细胞归巢的研究与进展[J].中国组织工程研究，2016，20(19)：2879-2888.
[14]Yamaguchi J，Kusano KF，Masuo O，et al.Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization[J].Circulation，2003，107(9)：1322-1328.
[15]Chiang KH，Cheng WL，Shih CM，et al.Statins，HMG-CoA reductase inhibitors，improve neovascularization by increasing the expression density of cxcr4 in endothelial progenitor cells[J].PLoS One，2015，10(8)：e0136405.
, 百拇医药
[16]Chan DA，Sutphin PD，Denko NC，et al.Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha[J].J Biol Chem，2002，277(42)：40112-40117.
[17]Zheng H，Fu G，Dai T，et al.Migration of endothelial progenitor cells mediated by stromal cell-derived Factor-1 alpha /CXCR4 via PI3K/Akt/eNOS signal transduction pathway[J].J Cardiovasc Pharmacol，2007，50(3)：274-280.
[18]Jiang BH，Zheng JZ，Aoki M，et al.Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells[J].Proc Natl Acad Sci U S A，2000，97 (4)：1749-1753.
, 百拇医药
[19]Dimmeler S，Fleming I，Fisslthaler B，et al.Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation[J].Nature，1999，399(6736)：601-605.
[20]Capoccia BJ，Shepherd RM，Link DC.G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism[J].Blood，2006，108(7)：2438-2445.
[21]Peyvandi AA，Abbaszadeh HA，Roozbahany NA，et al.Deferoxamine promotes mesenchymal stem cell homing in noise-induced injured cochlea through PI3K/AKT pathway[J].Cell Prolif，2018，51(2)：e12434.
[收稿日期]2018-10-19 [修回日期]2018-11-11
編辑/贾敏, 百拇医药(郑胜武 黄雄梅 庄兢 林根辉 杨宇 丁昕)
[5]Gray MJ，Zhang J，Ellis LM，et al.HIF-1alpha，STAT3，CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas[J].Oncogene，2005，24(19)：3110-3120.
[6]Ratajczak MZ，Zuba-Surma E，Kucia M.The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis，regeneration and tumorigenesis[J].Leukemia，2006，20(11)：1915-1924.
, 百拇医药
[7]Hou Z，Nie C，Si Z，et al.Deferoxamine enhances neovascularization and accelerates wound healing in diabetic rats via the accumulation of hypoxia-inducible factor-1α[J].Diabetes Res Clin Pract，2013，101(1)：62-71.
[8]Ikeda Y，Tajima S，Yoshida S，et al.Deferoxamine promotes angiogenesis via the activation of vascular endothelial cell function[J].
Atherosclerosis，2011，215(2)：339-347.
[9]Chekanov VS，Zargarian M，Baibekov I，et al.Deferoxamine-fibrin accelerates angiogenesis in a rabbit model of peripheral ischemia[J].Vasc Med，2003，8(3)：157-162.
, 百拇医药
[10]Niiyama H，Huang NF，Rollins MD，et al.Murine model of hindlimb ischemia[J].J Vis Exp，2009，23(23)：e1035.
[11]Krenning G，van Luyn MJ，Harmsen MC.Endothelial progenitor cell-based neovascularization：implications for therapy[J].Trends Mol Med，2009，15(4)：180-189.
[12]Botta R，Gao E，Stassi G，et al.Heart infarct in NOD-SCID mice：therapeutic vasculogenesis by transplantation of human CD34+ cells and low dose CD34+ KDR+ cells[J].FASEB J，2004，18(12)：1392-1394.
, 百拇医药
[13]邓蓉蓉，谢伊旻，谢林.间充质干细胞归巢的研究与进展[J].中国组织工程研究，2016，20(19)：2879-2888.
[14]Yamaguchi J，Kusano KF，Masuo O，et al.Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization[J].Circulation，2003，107(9)：1322-1328.
[15]Chiang KH，Cheng WL，Shih CM，et al.Statins，HMG-CoA reductase inhibitors，improve neovascularization by increasing the expression density of cxcr4 in endothelial progenitor cells[J].PLoS One，2015，10(8)：e0136405.
, 百拇医药
[16]Chan DA，Sutphin PD，Denko NC，et al.Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha[J].J Biol Chem，2002，277(42)：40112-40117.
[17]Zheng H，Fu G，Dai T，et al.Migration of endothelial progenitor cells mediated by stromal cell-derived Factor-1 alpha /CXCR4 via PI3K/Akt/eNOS signal transduction pathway[J].J Cardiovasc Pharmacol，2007，50(3)：274-280.
[18]Jiang BH，Zheng JZ，Aoki M，et al.Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells[J].Proc Natl Acad Sci U S A，2000，97 (4)：1749-1753.
, 百拇医药
[19]Dimmeler S，Fleming I，Fisslthaler B，et al.Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation[J].Nature，1999，399(6736)：601-605.
[20]Capoccia BJ，Shepherd RM，Link DC.G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism[J].Blood，2006，108(7)：2438-2445.
[21]Peyvandi AA，Abbaszadeh HA，Roozbahany NA，et al.Deferoxamine promotes mesenchymal stem cell homing in noise-induced injured cochlea through PI3K/AKT pathway[J].Cell Prolif，2018，51(2)：e12434.
[收稿日期]2018-10-19 [修回日期]2018-11-11
編辑/贾敏, 百拇医药(郑胜武 黄雄梅 庄兢 林根辉 杨宇 丁昕)