基于聚类分析探讨玫瑰痤疮的中医证型分布(1)
[摘要]通过分析玫瑰痤疮患者的临床资料及中医证候资料，探讨玫瑰痤疮的中医证型分布特点，为医生辨证施治及临床规范化研究提供新的思路及客观依据。参考相关文献并结合专家观点，制定《玫瑰痤疮患者中医证候信息采集表》对患者进行横断面研究，采集患者一般情况及中医四诊信息，对采集的数据进行频数统计及聚类分析。通过聚类分析得出，肺胃热盛证、脾胃湿热证、痰湿凝滞证、气滞血瘀证、肝郁化火证是临床常见证型。运用聚类分析得出的玫瑰痤疮证型分类符合临床实际，弥补了现有分型的局限性，对临床辨证施治具有一定的指导意义。
[关键词]玫瑰痤疮；四诊信息；聚类分析；证型分布
[中图分类号]R758.73+3 [文献标志码]B [文章编号]1008-6455(2018)12-0131-05
The Research of the Distribution of TCM Syndromes of Rosacea Based on
, 百拇医药
Cluster Analysis
JIAO Ye1， MIN Zhong-Sheng2
(1.Department of Dermatology， Nan Jing Arsmo Aesthetic Hospital， Nanjing 210000，Jiangsu，China； 2.Department of Dermatology， Nanjing University of Chinses Medicine Affiliated Jiangsu Province Hospital of Chinese Traditional Medicine， Nanjing 210029，Jiangsu，China)
Abstract： Through the analyses of the clinical data and TCM syndromes of rosacea patients， discuss the distribution characteristics of the TCM syndromes of rosacea， and provide a new thought and objective basis for the standardized clinical research and dialectical treatment of TCM.Referred to relevant literatures and expert opinions， made a cross-sectional study on the information collection table of TCM syndromes of rosacea patients， collected the general situation and the four diagnostic information of TCM of patients to analyze the collected data by frequency statistics and cluster analysis. By cluster analysis， lung-stomach heat retention syndrome， spleen-stomach damp-heat syndrome， phlegm-damp stagnation syndrome， Qi stagnation and blood stasis syndrome， liver depression transforming into fire syndrome were clinical common types. The classification of rosacea syndromes by cluster analysis was consistent with clinical practice， which made up the limitations of the existing classification， and had certain guiding significance for clinical differentiation of symptoms and signs.
, 百拇医药
Key words： rosacea； four diagnostic information；cluster analysis；symptoms distribution
玫瑰痤瘡(Rosacea)又名酒渣鼻，是一种累及面部血管及毛囊皮脂腺的慢性炎症性皮肤病。该病以阵发性潮红、持久性红斑、丘疹脓疱、肥大增生性改变为主要表现，常伴有面部干燥、瘙痒、灼热、刺痛等不适症状[1]，且影响美观，给患者身心健康带来极大影响，成为医学界及美容界关注的热点问题。其发病机制尚不十分清楚，微生物感染学说、先天免疫失调学说、血管神经失调学说是近年来讨论的焦点[2-3]。现代医学的治疗方法，如：外用维A酸、钙调磷酸酶抑制剂容易引起局部烧灼刺痛等不良反应，外用壬二酸药效温和但仅适用于轻中度患者，且对毛细血管扩张无效，口服抗生素能有效对抗炎症反应，但潜在的细菌药性及菌群失调的副作用也令人担忧，口服维A酸因有致畸风险，育龄期女性接受度低，激光、手术治疗适应证有限且价格昂贵[4]。中医辨证施治对于顽固性疾病常有明确的疗效，且不良反应发生率低，越来越受到患者的青睐。但目前的辨证分型方法尚存在一定的局限性，且各医家对该病的辨证存在分歧[5-7]，不能很好地指导临床治疗，本研究通过对玫瑰痤疮患者的中医证候资料进行聚类分析，探讨玫瑰痤疮的证型分布特点，以期为中医辨证施治提供新的思路，为临床规范化治疗提供客观依据。
1 资料和方法, http://www.100md.com(焦烨 闵仲生)
[关键词]玫瑰痤疮；四诊信息；聚类分析；证型分布
[中图分类号]R758.73+3 [文献标志码]B [文章编号]1008-6455(2018)12-0131-05
The Research of the Distribution of TCM Syndromes of Rosacea Based on
, 百拇医药
Cluster Analysis
JIAO Ye1， MIN Zhong-Sheng2
(1.Department of Dermatology， Nan Jing Arsmo Aesthetic Hospital， Nanjing 210000，Jiangsu，China； 2.Department of Dermatology， Nanjing University of Chinses Medicine Affiliated Jiangsu Province Hospital of Chinese Traditional Medicine， Nanjing 210029，Jiangsu，China)
Abstract： Through the analyses of the clinical data and TCM syndromes of rosacea patients， discuss the distribution characteristics of the TCM syndromes of rosacea， and provide a new thought and objective basis for the standardized clinical research and dialectical treatment of TCM.Referred to relevant literatures and expert opinions， made a cross-sectional study on the information collection table of TCM syndromes of rosacea patients， collected the general situation and the four diagnostic information of TCM of patients to analyze the collected data by frequency statistics and cluster analysis. By cluster analysis， lung-stomach heat retention syndrome， spleen-stomach damp-heat syndrome， phlegm-damp stagnation syndrome， Qi stagnation and blood stasis syndrome， liver depression transforming into fire syndrome were clinical common types. The classification of rosacea syndromes by cluster analysis was consistent with clinical practice， which made up the limitations of the existing classification， and had certain guiding significance for clinical differentiation of symptoms and signs.
, 百拇医药
Key words： rosacea； four diagnostic information；cluster analysis；symptoms distribution
玫瑰痤瘡(Rosacea)又名酒渣鼻，是一种累及面部血管及毛囊皮脂腺的慢性炎症性皮肤病。该病以阵发性潮红、持久性红斑、丘疹脓疱、肥大增生性改变为主要表现，常伴有面部干燥、瘙痒、灼热、刺痛等不适症状[1]，且影响美观，给患者身心健康带来极大影响，成为医学界及美容界关注的热点问题。其发病机制尚不十分清楚，微生物感染学说、先天免疫失调学说、血管神经失调学说是近年来讨论的焦点[2-3]。现代医学的治疗方法，如：外用维A酸、钙调磷酸酶抑制剂容易引起局部烧灼刺痛等不良反应，外用壬二酸药效温和但仅适用于轻中度患者，且对毛细血管扩张无效，口服抗生素能有效对抗炎症反应，但潜在的细菌药性及菌群失调的副作用也令人担忧，口服维A酸因有致畸风险，育龄期女性接受度低，激光、手术治疗适应证有限且价格昂贵[4]。中医辨证施治对于顽固性疾病常有明确的疗效，且不良反应发生率低，越来越受到患者的青睐。但目前的辨证分型方法尚存在一定的局限性，且各医家对该病的辨证存在分歧[5-7]，不能很好地指导临床治疗，本研究通过对玫瑰痤疮患者的中医证候资料进行聚类分析，探讨玫瑰痤疮的证型分布特点，以期为中医辨证施治提供新的思路，为临床规范化治疗提供客观依据。
1 资料和方法, http://www.100md.com(焦烨 闵仲生)
参见：首页 > 医疗版 > 疾病专题 > 皮肤科 > 皮肤附属器官疾病 > 痤疮(青春痘)