CO2点阵激光联合外用药物治疗白癜风疗效分析
国家皮肤与免疫疾病临床医学研究中心 北京 100034)
[摘要]目的：探究CO2点阵激光联合外用药物综合治疗白癜风的临床疗效。方法：选择笔者医院收治的白癜风患者90例，根据随机数字法将其分为两组。观察组：45例，采用CO2点阵激光+卤米松软膏+他克莫司軟膏治疗;对照组：45例，采用卤米松软膏+他克莫司软膏治疗，比较两组的治疗效果、不良反应发生情况、治疗后及随访的QOL和满意度评分，观察两组治疗前后的抗酪氨酸酶IgG抗体(TYRsIgG)、抗酪氨酸酶IgM抗体(TYRsIgM)的滴度(A值)及人可溶性细胞间粘附分子1(sICAM-1)水平。结果：观察组治疗总有效率88.89%，明显高于对照组的68.89%(P<0.05)。观察组治疗结束后1周、1个月、3个月的QOL及满意度评分均高于对照组(P<0.05)。治疗后一个月后，观察组的IgG、IgM抗体滴度及sICAM-1水平明显低于对照组(P<0.05)。观察组的不良反应发生率6.67%，与对照组的4.44%比较，无显著性差异(P>0.05)。结论：CO2点阵激光联合外用药物综合治疗白癜风，疗效显著，不良反应较少，提高了患者满意度。
[关键词]CO2点阵激光;白癜风;卤米松软膏;他克莫司软膏;满意度
[中图分类号]R758.4+1 [文献标志码]A [文章编号]1008-6455(2020)01-0045-04
Effect Analysis of CO2 Dot Matrix Laser Combined with Topical Drugs in the Treatment of Vitiligo
ZHOU Xing1， WU Yan2
[1.Department of Dermatology，Beijing No.6 Hospital，Beijing 100007，China; 2.Department of Dermatology (and Venerology)， Peking University First Hospital， Beijing Key Laboratory of Molecular Diagnosis on Dermatoses， National Clinical Research Center for Skin and Immune Diseases， Beijing 100034，China]
Abstract： Objective To explore the clinical efficacy of CO2 dot matrix laser combined with topical drugs in the treatment of vitiligo. Methods 90 patients with vitiligo admitted to our hospital were randomly divided into observation group (45 cases， CO2 dot matrix laser + halomethasone ointment + tacrolimus ointment treatment) and The control group (45 cases，treatment with halomethasone ointment + tacrolimus ointment)， compared the treatment effect， adverse reaction occurrence， QOL and satisfaction score after treatment and follow-up， anti-tyrosinase IgG antibody (TYRsIgG)， anti-tyrosinase IgM antibody (TYRsIgM) titer (A value) and human soluble intercellular adhesion molecule 1 (sICAM-1) levels before and after treatment. Results The total treatment efficiency of the observation group was 88.89%， which was significantly higher than that of the control group (68.89%) (P<0.05). The QOL and satisfaction scores of the observation group 1 week after treatment， 1 month after treatment and 3 months after treatment were higher than those of the control group (P<0.05). After one month of treatment， the IgG， IgM antibody titer and sICAM-1 levels in the observation group were significantly lower than those in the control group (P<0.05). The incidence of adverse reactions in the observation group was 6.67% compared with 4.44% in the control group， and there was no significant difference (P>0.05). Conclusion CO2 dot matrix laser combined with halomethasone ointment and tacrolimus ointment for the treatment of vitiligo， accelerate the disappearance of pigment and leukoplakia， with remarkable curative effect， safe and reliable， less adverse reactions， worth promoting., 百拇医药(周星 吴艳)
[摘要]目的：探究CO2点阵激光联合外用药物综合治疗白癜风的临床疗效。方法：选择笔者医院收治的白癜风患者90例，根据随机数字法将其分为两组。观察组：45例，采用CO2点阵激光+卤米松软膏+他克莫司軟膏治疗;对照组：45例，采用卤米松软膏+他克莫司软膏治疗，比较两组的治疗效果、不良反应发生情况、治疗后及随访的QOL和满意度评分，观察两组治疗前后的抗酪氨酸酶IgG抗体(TYRsIgG)、抗酪氨酸酶IgM抗体(TYRsIgM)的滴度(A值)及人可溶性细胞间粘附分子1(sICAM-1)水平。结果：观察组治疗总有效率88.89%，明显高于对照组的68.89%(P<0.05)。观察组治疗结束后1周、1个月、3个月的QOL及满意度评分均高于对照组(P<0.05)。治疗后一个月后，观察组的IgG、IgM抗体滴度及sICAM-1水平明显低于对照组(P<0.05)。观察组的不良反应发生率6.67%，与对照组的4.44%比较，无显著性差异(P>0.05)。结论：CO2点阵激光联合外用药物综合治疗白癜风，疗效显著，不良反应较少，提高了患者满意度。
[关键词]CO2点阵激光;白癜风;卤米松软膏;他克莫司软膏;满意度
[中图分类号]R758.4+1 [文献标志码]A [文章编号]1008-6455(2020)01-0045-04
Effect Analysis of CO2 Dot Matrix Laser Combined with Topical Drugs in the Treatment of Vitiligo
ZHOU Xing1， WU Yan2
[1.Department of Dermatology，Beijing No.6 Hospital，Beijing 100007，China; 2.Department of Dermatology (and Venerology)， Peking University First Hospital， Beijing Key Laboratory of Molecular Diagnosis on Dermatoses， National Clinical Research Center for Skin and Immune Diseases， Beijing 100034，China]
Abstract： Objective To explore the clinical efficacy of CO2 dot matrix laser combined with topical drugs in the treatment of vitiligo. Methods 90 patients with vitiligo admitted to our hospital were randomly divided into observation group (45 cases， CO2 dot matrix laser + halomethasone ointment + tacrolimus ointment treatment) and The control group (45 cases，treatment with halomethasone ointment + tacrolimus ointment)， compared the treatment effect， adverse reaction occurrence， QOL and satisfaction score after treatment and follow-up， anti-tyrosinase IgG antibody (TYRsIgG)， anti-tyrosinase IgM antibody (TYRsIgM) titer (A value) and human soluble intercellular adhesion molecule 1 (sICAM-1) levels before and after treatment. Results The total treatment efficiency of the observation group was 88.89%， which was significantly higher than that of the control group (68.89%) (P<0.05). The QOL and satisfaction scores of the observation group 1 week after treatment， 1 month after treatment and 3 months after treatment were higher than those of the control group (P<0.05). After one month of treatment， the IgG， IgM antibody titer and sICAM-1 levels in the observation group were significantly lower than those in the control group (P<0.05). The incidence of adverse reactions in the observation group was 6.67% compared with 4.44% in the control group， and there was no significant difference (P>0.05). Conclusion CO2 dot matrix laser combined with halomethasone ointment and tacrolimus ointment for the treatment of vitiligo， accelerate the disappearance of pigment and leukoplakia， with remarkable curative effect， safe and reliable， less adverse reactions， worth promoting., 百拇医药(周星 吴艳)